| Project/Area Number |
09671560
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
TAENAKA Nobuyuki Osaka University Hospital, Lecturer, 医学部・附属病院, 講師 (10127243)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Masaji Osaka University Hospital, Assistant Professor, 医学部・附属病院, 助手 (10172701)
島岡 要 大阪大学, 医学部・附属病院, 助手 (40281133)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | mechanical ventilation / diaphragmatic fatigue / pressure support ventilation / recovery from fatigue / phrenic nerve stimulation / airway occlusion pressure / diaphragmatic electromyogram |
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| Research Abstract |
Objectives : To examine the effects of pressure-support ventilation on recovery from acute diaphragmatic fatigue.
Design : Prospective laboratory trial.
Setting : Experimental laboratory.
Subjects : Twenty-one healthy, adult New Zealand white rabbits.
Interventions : Diaphragmatic fatigue was induced with 50-Hz phrenic nerve stimulation for 30 mins.Recovery was compared between pressure-support ventilation 0 cm H_2O (SB), 10 cm H_2O (P10), and 20 cm H_2O (P20) for 90 mins immediately after the end of the fatigue inducing procedure.
Measurements and Main Results : After the fatigue-inducing procedure, pressure-support ventllation reduced transdiaphrag-matic pressure and integrated diaphragmatic electromyogram both at P20 and P1O, but not in SB.Recovery was assessed by airway occlusion pressure (Poccl) generated by high- (100Hz) and low- (20Hz) frequency phrenic nerve stimulation.Poccl at 100 Hz was lower in P1O and P20 than in SB (74.6 * 6.2 [SEM] %, 66.9 * 3.3%, and 94.8 * 3.6% of the baseline at 90 mins for P10, P20, and SB, respectively), while those at 20 Hz showed no differences between the three groups.
Conclusion : Recovery from acute diaphragmatic fatigue might be disturbed with pressure-support ventilation.
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