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Effect of Interferon-α treatment for HCV-positive renal transplant recipients and hempdialysed patients.

Research Project

Project/Area Number 09671652
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionDepartment of Urology, Kidney Center, Tokyo Women's Medical University

Principal Investigator

TANABE Kazunari  Tokyo Women's Medical University, Lecturer, 医学部, 講師 (80188359)

Co-Investigator(Kenkyū-buntansha) YAGISAWA Takashi  Tokyo Women's Medical University, Lecturer, 医学部, 講師 (80167692)
TOKUMOTO Tadahiko  Tokyo Women's Medical University, Assistant, 医学部, 助手 (30246540)
TOMA Hiroshi  Tokyo Women's Medical University, Professor, 医学部, 教授 (90075549)
HAYASHI Naoaki  Tokyo Women's Medical University, Professor, 医学部, 教授 (10075286)
HASHIMOTO Etuko  Tokyo Women's Medical University, Lecturer, 医学部, 講師 (40130273)
古賀 祥嗣  東京女子医科大学, 医学部, 助手 (30277123)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsHCV / renal transplantation / Interferon-α / C型肝炎 / 慢性腎不全 / インターフェロン
Research Abstract

(Aim & method)
Natural typer interferon α(INFα)was administered to HCV positive hemodialysis and transplant patients in order to eliminate HCV.Hemodialysed patients were received INFα500×10^4U for 14 days and followed by 500×10^6U, 3 times/week, for 6 months. Renal transplant recipients with HCV were administered INFα1000×10^6U for 14days and followed by 1000×10^6U, 3 times/week for 6 months.
(Results)
12 hemodialysed patients an 10 renal transplant recipients were enrolled in this study. All 22 patients showed at least partial response with normalization of transaminase and negative HCV-RNA.11 patients showed complete response without returning HCV-RNA positive after 6 months of conclusion of INFαtreatment.
(Conclusion)
INFαtreatment for the hemodialyzed patients and renal transplant recipients with HCV was highly effective to eliminate HCV.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] T.Tokumoto: "Effect of interferon(INF-alpha)for prevention of hepatitis C transmission from a seropositive donor to a seronegative Recipient in renal transplantation."Transplant Proc.. 28. 1503-1504 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 田邉一成: "腎移植と肝疾患"腎と透析. 42. 659-662 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "LONG-TERM RENAL FUNCTION IN NON-HEAT-BEATING DONOR KIDNEY TRANSPLANTATION"Transplantation. 66. 1708-1713 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "Infectious Complications in ABO-Incompatible Living Donor Kidney Transplantation : A Single Center Experience"Transplantation Proceedings. 30. 3130-3132 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Tokumoto: "Effect of interferon-alpha teratment in renal transplant recipients with chronic hepatitis C,"Transplant Proc.. 30. 3270-3272 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "Impact of OKT3 Treatment for Steroid Resistant Rejection of Renal Allgragts : The Long-Term"Transplant Proc.. 31. 2870-2871 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "Long-Term Results in Mizoribine-Treated Renal Transplant Recipients : A Prospective, Randomized Trial of Mizoribine and Azathioprine Under Cyclosporine-Based Immunosuppression"Transplant Proc.. 31. 2877-2879 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Toma: "Pregnacy in women receiving renal dialysis or transplantation in Japan : a nation wide survey"Nephrol Dial Transplantation. 14. 1511-1516 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 田邉一成: "移植腎を長期に生着させるためには〜合併症とその対策-肝障害"腎と透析. 47. 511-518 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Tokumoto: "Kidney transplantation from donor with HCV antibody positive and HCV-RNA negative"Transplant Proc.. (in printing). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Tokumoto: "Effect of interferon(INF-alpha) for prevention of hepatitis C transmission from a seropositive donor to a seronegative Recipient in renal transplantation."Transplant Proc.. 28. 1503-1504 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "Renal transplantation and liver disease"Kidney and Dialysis. 42. 659-662 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "LONG-TERM RENAL FUNCTION IN NON-HEAT-BEATING DONOR KIDNEY TRANSPLANTATION."Transplantation. 66. 1708-1713(12) (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "Infectious Complications in ABO-Incompatible Living Donor Kidney Transplantation : A Single Center Experience."Transplantation Proceedings. 30. 3130-3132 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Tokumoto: "Effect of interferon-alpha treatment in renal transplant recipients with chronic hepatitis C"Transplant Proc.. 30. 3270-3272 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "Impact of OKT3 Treatment for Steroid Resistant Rejection of Renal Allgrafts : The Long-Term Outcome at a Single Center."Transplant Proc.. 31. 2870-2871 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "Long-Term Results in Mizoribine-Treated Renal Transplant Recipients : A Prospective, Randomized Trial of Mizoribine and Azathioprine Under Cyclosporine-Based Immunosuppression."Transplant Proc.. 31. 2877-2879 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Toma: "Pregnacy in women receiving renal dialysis or transplantation in Japan : a nation wide survey."Nephrol Dial Transplantation. 14. 1511-1516 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Tanabe: "To keep renal allgraft for long -term -liver dyofution-"Kidney and Dialysis. 47. 511-518 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Tokumoto: "Kidney transplantation from donor with HCV antibody positive and HCV-RNA negative."Transplant Proc.. (in printing). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tokumoto T,Tanabe K et al: "Effect of interferon-α treatment in renal transplant recipients with Chronic Hepatitis C"Transplant Proc. 30. 3270-3272 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 徳本直彦ら: "移植腎長期生着-合併症とその対策-肝障害"腎と透析. 47. 511-518 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanabe K,Kitani R et al: "Long-term results in human T-cell leukemia virus type 1-positive renal transplant recipients"Transplant Proc. 30. 3168-3170 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanabe K,Ohima et al: "Long-term renal function in non-heart-beating down kidney transplantation"Transplantation.

    • Related Report
      1999 Annual Research Report
  • [Publications] Kawase et al: "Ex vivo reno-vascular reconstruction in living kidney transplantation"Transplant Proc. 30. 2993-2994 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanabe K et al: "Surgical complications of pedidric kidney transplantation: A single center experience with the extraprtitonal t*****"J. Urol. 160. 1212-1215 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 田辺一成: "Long-term results of ABO-incompatible living kidney transplantation" Transplantation. 65. 224-228 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田辺一成: "Long-term results of living Kidney transplantation under tacrolimus immunosuppression : a single certer experience" Transplant Proc. 30. 1224-1226 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田辺一成: "Suigical complications of pediatric kidney transplantation:a single center experience with the extraperitoneal technique" J.Urol. 160. 1212-1215 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 徳本直彦: "Effect of interferon-alfa treatment in renal transplant recibients with chronic hepatitis C" Transplant Proc. 30. 3270-3272 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田辺 一成: "腎移植と肝疾患" 腎と透析. 42. 659-662 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 田部 一成: "腎移植の成功率" 透析ケア. 増刊. 40-54 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanabe: "Long-tem renal-function after pregrany in reul translait" Transplant Proc. 29. 1567-1568 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanabe: "Comparative study of Cytomgalevirus antigenemia assay,PCR Sevology,and thellc,alassot tuthealy diagnosis and monitoving of CMV intection ofte revel trasplantation" Transplatation. 64. 1721-1725 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanabe: "molecular regulation of inta cells adhesion molecule 1(1CAM-1) expression in renal cell carcinoma" Wol Res. 25. 231-238 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanabe: "Retroviral transduction of intercellula adhesion molecule-1 enhances endo thelial attachment of blulda cencc" Wol Res. 25. 401-405 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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