|Budget Amount *help
¥3,400,000 (Direct Cost : ¥3,400,000)
Fiscal Year 1998 : ¥1,500,000 (Direct Cost : ¥1,500,000)
Fiscal Year 1997 : ¥1,900,000 (Direct Cost : ¥1,900,000)
The purpose of this study was to compare core temperatures and brain temperatures after complete but intermittent occlusions of umbilical cord. Thermocouple probes were placed in the para-sagittal parietal cortex, ascending aorta, and jugular vein of eight near-term fetal, sheep and in the maternal descending aorta. Three days later, after an initial control period, the umbilical cord was occluded for 5 min, followed by a 30-min recovery period, and this cycle was repeated 4 times. Temperature changes, blood gases, and plasma glucose, lactate and adenosine were measured. In the first occlusion period, body core temperature increased 0.12 C over control, and then declined to baseline after cord release, and this pattern was repeated with subsequent occlusion. Plasma adenosine increased 2.4-fold during the first occlusion, but not during subsequent occlusion, despite a continuing regulator of cerebral metabolism. We conclude that brain temperature fails to increase because of diminished heat production by the brain and increases in cerebral blood flow, responses which delay complete depletion of adenosine 5Ztriphosphate stores in brain tissue.