| Project/Area Number |
09672011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Nihon University |
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Principal Investigator |
TANAKA Takaaki Nihon University, Dentistry at Matsudo, Lecturer, 松戸歯学部, 講師 (30207104)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUKAWA Kazuhiro Nihon University, Dentistry at Matsudo, Assistant Professor, 松戸歯学部, 助教授 (40050025)
MEGA Junich Nihon University, Dentistry at Matsudo, Assistant Professor, 松戸歯学部, 助教授 (40190946)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | silver-inorganic anti-microbial reagent / anti-microbial prosthesis / oral microorganisms / 銀系無機抗菌剤 / Actinomyces viscosus / 抗菌作用 / 口腔内細菌 / 抗菌剤 / 付着 / プラーク |
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| Research Abstract |
The effect of silver-inorganic anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) on oral microorganisms were examined.
1. Minimam inhibitory concentration (MIC) of anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) for S.mutans was 7.5mg/ml and1.3mg. The antimicrobial action was bacteriostatic one. The resin plate thatcontaining both anti-microbial reagent showed remarkably reduced the microorganisms on its plate.
2. MIC of NOBARON'TM for C.albicans was 500 mug/ml, and the bacterial action was candidacidal one.Denture containing 5wt% NOBARON^<TM> showed a remarkable decrease in the amount of Candida coloniesby imprint culture method.
3.1) The contact angle of three coating materials (429R,740 and Brightener^<TM>) was 37.8 degree, 28.9 degree and 27.9 degree on self- curing acrylic resin, and that specific gravity was 1 .00, 1.04 and 1.07. Brightener^<TM> showed high knoop hardness within three material. For elementary analysis, Brightener^<TM> containing anti-microbial reagent has more Ag intensity than thats of self-curing acrylic resin.
2) MIC of anti-microbial reagent (ION PURE^<TM> and NOBARON^<TM>) for A.viscosus was 2.5mg/ml and 1.3mg/ml. Brightener^<TM> containing the reagent has more anti-microbial effect than other coating materials.
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