Studies on benzo [c] phenanthridine alkaloid using novel palladium reagents
Grant-in-Aid for Scientific Research (C)
|Allocation Type||Single-year Grants|
|Research Institution||Okayama University|
HARAYAMA Takashi Faculty of Pharmaceutical Sciences, Okayama University Profesor, 薬学部, 教授 (30025712)
|Project Period (FY)
1997 – 1998
Completed(Fiscal Year 1998)
|Budget Amount *help
¥2,900,000 (Direct Cost : ¥2,900,000)
Fiscal Year 1998 : ¥1,100,000 (Direct Cost : ¥1,100,000)
Fiscal Year 1997 : ¥1,800,000 (Direct Cost : ¥1,800,000)
|Keywords||palladium reagent / chelerythrine / nitidine / benzo [c] phenanthridine / benzo [d] naphthopyranone / biaryl coupling reaction / ベンゾ[C]フェナンスリジン|
1) Development of general synthetic method for benzo[c]phenanthridine alkaloid using novel palladium reagents
A novel palladium reagent prepared from equimolar Pd(OAc)_2, DPPP, and Bu3P was useful for the internal biaryl coupling reaction of not only triflate-amide but also halo-amide as leaving group. By using this novel Pd reagent, benzo[c]phenanthridine alkaloids, chelerythrine and nitidine were synthesized in good yields.
2) Synthetic studies on benzo[d]naphthopyranones
Benzo[d]naphthopyranones, arnottin I, was synthesized by using typical Heck* s reaction conditions.
3) Synthetic studies on phenanthridine alkaloids
Phenanthridine alkaloid, trisphaeridine, was synthesized via biaryl coupling reaction using palladium reagent.
4) Mechanistic aspect of novel Palladium reagent [Pd(OAc)_2-PPP-Bu_3P]
It was found out that molar ratio of Pd phosphine = 1 : 3 is essentially necessary for biaryl coupling reaction
Research Output (12results)