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Lordosis inhibiting systems in the septum and dorsal raphe nucle-us

Research Project

Project/Area Number 09680802
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionWaseda University

Principal Investigator

YAMANOUCHI Korehito  Waseda University, School of Human Sciences, Professor, 人間科学部, 教授 (10053357)

Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsLordosis Inhibition / Septum / Dorsal Raphe Nucleus / Sexual Differentiation / Estrogen / Serotonergic Neuron / Neural Transection / Rats / ロードーシス / 抑制力
Research Abstract

The lateral septum (LS) exerts an inhibitory influence in regulation of female characteristic sexual behavior, such as lordosis and soliciting behavior in both female and male rats. The inhibitory mechanism also exist in the serotonergic neurons in the dorsal raphe nucleus (DRN). In male rats, these female sexual behavioral patterns are very rare, even when treated with large doses of estrogen. The low incidence of female sexual behavior in males is thought to be cased by strong inhibitory influences in the LS and DRN.In this experiment, these inhibitory mechanisms have been analyzed by neuroendocrinological methods and following results were obtained. 1 : Since the ventral cut of the anterior part of the DRN enhanced lordotic behavior in both male and female rats, anteroventral projections of this nucleus are involved in lordosis inhibitory mechanisms. 2 : Female levels of lordotic activity was induced by transection of the medial forebrain bundle in male rats. This suggests an importance of the bundle as a pathway for lordosis inhibiting influence. 3 : To clarify the role of estrogen in the inhibitory systems of the LS and DRN, estradiol was implanted directly in these areas and lordosis was observed in subthreshold doses of estradiol benzoate-injected castrated female and male rats. As a result, estrogen implanted in the LS butnot in the DRN facilitated lordosis in female rats. This result indicates that the inhibition for lordosis in the LS is released directly by estrogen but not in the DRN.Furthermore, implantation of estrogen into the LS in males had no effect on lordosis. Thus, the reason of low incidence of female sexual behavior in male rats is the development of strong inhibition in the LS which can not be released directly by estrogen.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Matsumoto, T.: "Effects of p-chlorophenylalanine on reflexive and noncontact penile erections in male rats" Physiol.Behav.61・2. 165-168 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kakeyama, M.: "Lordosis in male rats : Effect of dorsal raphe nucleus cuts." Horm.Behav.32・1. 60-67 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsumoto T.: "Effects of p-chlorophenylalanine on male sexual behavior in female rats with mesencephalic raphe nuclei lesions." Endocrine J.44・3. 383-388 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kakeyama, M.: "Facilitatory effect of ventral cut of dorsal raphe nuclues on lordosis in female rats." Endocrine J.44・4. 589-593 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kondo, Y.: "Potentiation of ejaculatory activity by median raphe nucleus lesions in male rats : Effect of p-chlorophenylalanine." Endocrine J.44・6. 873-879 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamanouchi, K.: "Brain mechnanisms inhibiting the expression of heterotypical sexual behavior in rats." In ‘Neural Control of Renpoduction-Physiology and Behavior'Jap.Sci.Soc.Press. 219-235 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Satou, M.: "Inhibitory effect of progesterone on lordosis in male and female rats with septal lesions." Advances in Comparative Endocrinology 2. 1759-1763 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山内兄人: "性行動神経制御機構の性分化" アニテック. 9・2. 10-15 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maekawa, F.: "Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats." Brain Res.813・1. 195-199 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Satou, M.: "Inhibitory effect of progesterone on androgen-induced lordosis in ovariectomized rats." Endocrine J.45・2. 235-239 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maekawa, F.: "Differential effects of dorsal raphe nucleus lesions on pseudopregnfancy induced by reserpine or vaginal stimulation in female rats." J.Reprod, Develop.44・4. 337-343 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamashita-Suzuki, K.: "Inhibitory pathway for female sexual behavior in male rat brain : Effect of medial forebrain bundle (MFB) cuts" J.Reprod.Develop.44・4. 393-398 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山内兄人: "性行動制御機構とその性分化における性ホルモンの役割" 神経研究の進歩. 42・4. 610-623 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山内兄人: "雌ラットの性行動と性ホルモン" Hormone Frontier In Gynecology. 5・3. 297-304 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山内兄人: "ラットの性行動と性分化における性ホルモンの働き" 遺伝. 52・10. 70-75 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 山内兄人: "射精のメカニズム-解剖-中枢神経系" [性機能障害」, 南山堂. 35-42 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamanouchi, K.: "Brain mechnanisms inhibiting the expression of heterotypical sexual behavior in rats." Neural Control of Reproduction-Physiology and Behavior'Maeda, K., Tukamura, H.and Yokoyama, A.(eds), Jap.Sci.Soc.Press/Tokyo. 219-235 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsumoto, T., Kondo, Y., B.J.Sachs and Yamanouchi, K.: "Effects of p-chlorophenylalanine on reflexive and noncontact penile erections in male rats" Physiol.Behav.61,2. 165-168 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kakeyama, M.and Yamanouchi, K.: "Lordosis in male rats : Effect of dorsal raphe nucleus cuts." Horm.Behav.32,1. 60-67 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsumoto, T.and Yamanouchi, K.: "Effects of p-chlorophenylalanine on male sexual behavior in female rats with mesencephalic raphe nuclei lesions." Endocrine J. 44,3. 383-388 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kakeyama, M., Negishi, M.and Yamanouchi, K.: "Facilitatory effect of ventral cut of dorsal raphe nuclues on lordosis in female rats." Endocrine J. 44,4. 589-593 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kondo, Y.and Yamanouchi, K.: "Potentiation of ejaculatory activity by median raphe nucleus lesions in male rats : Effect of p-chlorophenylalanine." Endocrine J. 44,6. 873-879 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Satou, M.and Yamanouchi, K.: "Inhibitory effect of progesterone on lordosis in male and female rats with septal lesions." Advances in Comparative Endocrinology 2, Kawashima, S.and Kikuyama, S.(eds) Monduzzi/Bologna. 1759-1763 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maekawa, F., Tsukahara, S., Tsukamura, H., Maeda K.-I.and Yamanouchi, K.: "Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats." Brain Res.813,1. 195-199 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Satou, M.and Yamanouchi, K.: "Inhibitory effect of progesterone on androgen-induced lordosis in ovariectomized rats." Endocrine J.45(2). 235-239 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maekawa, F.and Yamanouchi, K.: "Differential effects of dorsal raphe nucleus lesions on pseudopregnfancy induced by reserpine or vaginal stimulation in female rats." J.Reprod.Develop.44,4. 337-343 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamashita-Suzuki, K.and Yamanouchi, K.: "Inhibitory pathway for female sexual behavior in male rat brain : Effect of medial forebrain bundle (MFB) cuts" J.Reprod.Develop.44,4. 393-398 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamanouchi, K.and Satou Motoyasu: "Role of sex hormones in neural regulation of sexual behavior and sexual diffeentiation in rats. (In Japanese)" Advances in Neurological Sciences. 42,4. 610-623 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maekawa,F.: "Inhibitory effect of neural transections of dorsal raphe nucleus on induction of nocturnal prolactin surge by vaginal stimulation in ovariectomized rats." Brain Res.813・1. 195-199 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Satou,M.: "Inhibitory effect of progesterone on androgen-induced lordosis in ovariectomized rats." Endocrine J.45・2. 235-239 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Maekawa,F.: "Differential effects of dorsal raphe nucleus lesions on pseudopregnfancy induced by reserpine or vaginal stimulation in female rats." J.Reprod.Develop.44・4. 337-343 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamashita-Suzuki,K.: "Inhibitory pathway for female sexual behavior in male rat brain:Effect of medial forebrain bundle(MFB)cuts" J.Reprod.Develop.44・4. 393-398 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山内兄人: "性行動制御機構とその性分化における性ホルモンの役割" 神経研究の進歩. 42・4. 610-623 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山内兄人: "雌ラットの性行動と性ホルモン" Hormone Frontier In Gynecology. 5・3. 297-304 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山内兄人: "ラットの性行動と性分化における性ホルモンの働き" 遺伝. 52・10. 70-75 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山内兄人: "射精のメカニズム-解剖-中枢神経系" [性機能障害],南山堂. 35-42 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kakeyama,M., Yamanouchi,K.: "Lordosis in male rats : Effect of dorsal raphe nucleus cuts" Hormone and Behavior. 32・1. 60-67 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumoto,T., Yamanouchi,K.: "Effect of p-chlovophenylalanine on male sexual behavior in female rats with mesencephalic rarhe nuclei lesions." Endocrine Journal. 44・3. 383-388 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kakeyama,M. Negishi.M., Yamanouchi,K.: "Facilitatory effect of rentral cut of dorsal rarhe nucleus on lordosis in female rat" Endocrine Journal. 44・4. 589-593 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumoto,T. Kondo,Y. Sochs,B.J, Yamanouchi,K.: "Effect of p-chlorophenylalanine on reflexive and non-contact Penile erections in male rats." Physiology and Behavior. 61・2. 165-168 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kondo,Y., Yamanouchi,K.: "Potentiation of ejaculatory activity bu median raphe nucleus lecions in male rats : Effect of p-chlorocheny laranine" Endocrine Journal. 44・6. 873-879 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamanouchi,K.: "Brain mechanisms inhibiting the exprescion of heterotypical sexual behavior in rats" In “Neural control of Reproduction-Physiology and Behavior" edited by Maeda et al. 219-235 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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