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Molecular epidemiology of HIV/AIDS and related diseases in Southern Africa

Research Project

Project/Area Number 10041191
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionTokyo Medical Dental University

Principal Investigator

YAMAMOTO Naoki  Tokyo Medical Dental University, Professor, 大学院・医歯学総合研究科, 教授 (00094053)

Co-Investigator(Kenkyū-buntansha) TERUMURA Hiroshi  Yamanashi Medical University, Lecturer, 医学部, 講師 (50217436)
SUZUKI Hiroshi  Niigata University School of Medicine, Professor, 医学部, 教授 (20091704)
SUGAMURA Kazuo  Tohoku University School of Medicine, Professor, 大学院・医学研究科, 教授 (20117360)
御手洗 聡  国際協力事業団ザンビア感染症対策プロジェクト, 長期専門
沼崎 義夫  国際協力事業団ザンビア感染症対策プロジェクト, チーフアドバイザ
宍戸 春美  国立療養所東京病院, 臨床研究部, 部長
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥25,100,000 (Direct Cost: ¥25,100,000)
Fiscal Year 2000: ¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 1999: ¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 1998: ¥9,300,000 (Direct Cost: ¥9,300,000)
KeywordsHIV infection / AIDS / TB / Africa / Southern africa / Zambia / South africa / エイズ / ジンバブエ / HIV
Research Abstract

Southern Africa has the highest prevalence of HIV-1 infection in the world and the following strategies have been priority in order to improve this situation :
1. To understand the natural history of HIV infection in southern Africa,
2. To develop an affordable and effective treatment for HIV infected people,
3. To develop a safe and effective HIV vaccine,
4. To develop and implement a mechanism that would prevent mother to child transmission(MTCT)of HIV,
5. To develop a faster TB drug-resistant monitoring assay.
In order to understand the natural history of HIV infection, we recruited asymptomatic patients and followed them for 3 years. TB was identified as the highest cause of death in these patients.
A double blinded study was carried out in order to determine an effective and affordable drug for HIV treatment. CD4 counts were high in patients who maintained high drug levels in their plasma.
To determine the distribution of HIV-1 strains in Zambia for vaccine development, we analysed the nucleotide sequences in Lusaka and found the predominance of HIV-1 env subtype C like with the emergence of HIV-1 env subtypes D-like and G-like. There is a need for continued studies to monitor the changing dynamics of the HIV-1 epidemic in Zambia, especially along the bordering areas.
To determine an effective prevention method of MTCT, we found that intrauterine transmission and during delivery were equally important for the transmission of HIV to babies in Zambia.
We found a high rate of TB drug-resistant mycobacterium in Lusaka.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Sugiura, Y.他: "Host immune profiles and genotyping analysis of HIV-1 among Japanese hemophiliac patients"Fukushima Journal of Medical Science. 45. 53-62 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 照沼裕: "ザンビアのHIV感染の疫学"山梨医科大学雑誌. 13. 1-7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Chinsembu, K. C.他: "Identification of human herpes virus-8 sequences in Zambian adult Kaposi's sacroma patients"Zambian Journal of Medicine and Health Sciences. 2. 33-35 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ito, M.他: "HIV-1 Tat protein inhibits interleukin-12 produciton by human PBMC"AIDS Research and Human Retroviruses. 14. 843-847 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saijo, M.他: "Respiratory syncytial virus infection in children with acute respiratory infections in Zambia"Epidemiol. Infect.. 121. 397-400 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Chinsembu, K.C., Terumura, H., and Matondo, P.: "Identification of human herpes virus-8 sequences in Zambian adult Kaposis sarcoma patients."Zambian Journal of Medicine and Health Sciences. 2. 33-35 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Saijo, M., Terumura, H., Mizuta, K., Mpabalwani, E.M., Monze, M., Oshitani, H., Luo, N., Suzuki, H., Numazaki, Y.: "Respiratory syncytial virus infection in children with acute respiratory infections in Zambia."Epidemiol.Infect.. 121. 397-400 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ito, M., Ishida, T., He, L., Tanabe, F., Yang, R., Miyakawa, Y., and Terumura, H.: "HIV-1 Tat protein inhibits Interleukin-12 production by human PBMC."AIDS Research and Human Retroviruses. 14. 843-847 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fleming, A.F., Terumura, H., Tembo, C., Mantina, H.: "Leukaemias in Zambia."Leukemia. 13. 1292-1293 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Matondo, P., Terumura, H.: "Ulna claw hand as a complication of herpes zoster."CME BULLETIN Sexually Transmitted Infections & HIV. 3. 53-54 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sugiura, Y., Terumura, H., Yamamoto, T., Ishikawa, M., Sato, J., Toyota, T., Iwasaki, Y.: "Host immune profiles and genotyping analysis of HIV-1 among Japanese hemophiliac patients."Fukushima Journal of Medical Science. 45. 53-62 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] He, L., Terumura, H., Tanabe, F., Hanabusa, H., Iwamoto, A., Oka, S., Chiba, N., Kurimoto, M., Ikeda, M., Okamura, H., Ito, M.: "IL-18 and IL-1β productions are decreased in HIV-1-seropositive haemophiliacs but not in HIV-1-seropositive non-haemophiliacs."AIDS Research and Human Retroviruses.. 16. 345-353 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Deng, X., Terumura, H., Handema, R., Sakamoto, M., Kitamura, T., ito, M., Akahane, Y.: "Higher prevalence and viral load of TT virus in saliva than in the corresponding serum : another possible transmission route and replication site of TT virus."J Medical Virology. 62. 531-537 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Handema, R., Terumura, H., Kasolo, F., Kasai, H., Sichone, M., Mulundu, G., Deng, X., Ichiyama, K., Mitarai, S., Honda, M., Yamamoto, N., Ito, M.: "Emergence of new HIV-1 subtypes other than subtype C among antenatal women in Lusaka, Zambia."AIDS Research and Human Retroviruses. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Owada, T., Motomura, T., Miyashita-Ogawa, Y., Kawada-Homma, M., Onishi, M., Matondo, P., Terumura, H., Numazaki, Y., Yamashita, S., Yamamoto, N.: "Antibody masking renders HIV-1 resistant to the cationic membrane filtration through alteration of its electrostatic character."J.Virological Methods. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Dai, J.H., Iwatani, Y., Ishida, T., Terumura, H., Kasai, H., Iwakura, Y., Fujiwara, H., Ito, M.: "Glycyrrhizin enhances IL-12 production in peritoneal macrophages."Immunology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Handema,R. 他: "Emergence of new HIV-1 subtypes other than subtype C among antenatal women in Lusaka, Zambia"AIDS Research and Human Retroviruses. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Owada,T. 他: "Antibody masking renders HIV-1 resistant to the cationic membrane filtration through alteration of its electrostatic character"J.Virological Methods. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Dai,J.H. 他: "Glycyrrhizin enhances IL-12 production in peritoneal macrophages "Immunology. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 照沼裕 他: "ザンビアにおけるエイズ治療の足掛かり"化学療法の領域. 16. 483-488 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] He,L. 他: "IL-18 and IL-1β productions are decreased in HIV-1-seropositive haemophiliacs but not in HIV-1-seropositive non-haemophiliacs"AIDS Research and Human Retroviruses. 16. 345-353 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Deng,X. 他: "Higher prevalence and viral load of TT virus in saliva than in the corresponding serum : another possible transmission route and replication site of TT virus"J Medical Virology. 62. 531-537 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fleming, A. F., Terunuma, H., Tembo, C., Mantina, H.: "Leukaemias in Zambia"Leukemia. 13. 1292-1293 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matondo, P., Terunuma, H.: "Ulna claw hand as a complicantion of herpes zoster"CME BULLETIN Sexually Transmitted Infections & HIV. 3. 53-54 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sugiura, Y., Terunuma, H., Yamamoto, T. et al.: "Host immune profiles and genotyping analysis of HIV-1 among Japanese hemophiliac patients"Fukushima Journal of Medical Science. 45. 53-62 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 照沼裕,沼崎義夫: "ザンビアにおけるエイズ治療の足掛かり"化学療法の領域. 16. 483-488 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] He, L., Terunuma, H., Tanabe, F. et al.: "IL-18 and IL-1β productions are decreased in HIV-1-seropositive haemophiliacs but not in HIV-1-seropositive non-haemophiliacs"AIDS Pesearch and Human Retroviruses. 16. 345-353 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Brandful, J.A., Apeagyei, F.A.,…Yamamoto, N. et al.: "Relationship between immunoclinical status and prevalence of viral sexually transmitted diseases among human immunodeficiency virus-1 seropositive patients in Ghana."Viral Immunology. 12. 131-137 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamamoto, N. and Hinuma, Y: "Laboratory Diagnosis of Viral Infection"Marcel Dekker、 Inc. 14 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 照沼裕: "ザンビアのHIV感染の疫学" 山梨医科大学雑誌. 13. 1-7 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chinsembu,K.C.: "Identification of human herpes virus-8 sequences in Zambian adult Kaposi's sacroma patients." Zambian Journal of Medicine and Health Sciences. 2. 33-35 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito,M.: "HIV-1 Tat protein inhibits interleukin-12 production by human PBMC." AIDS Research and Human Retroviruses. 14. 843-847 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Saijo,M.: "Respiratory syncytial virus infection in children with acute respiratory infections in Zambia." Epidemiol.Infect.121. 397-400 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matondo,P.: "Repeat episodes of herpes zoster in an AIDS-orphan." Int.J.Infect.Diseases. (in press).

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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