| Project/Area Number |
10410027
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
実験系心理学
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| Research Institution | Kurume University |
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Principal Investigator |
TSUDA Akira Kurume University. Professor, 文学部, 教授 (40150817)
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| Co-Investigator(Kenkyū-buntansha) |
TSUDA Shigeko Kurume University. Associate Professor, 文学部, 講師 (20197700)
YAMADA Shigeto Saga Medical University. Professor, 医学部, 教授 (20158190)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥9,200,000 (Direct Cost: ¥9,200,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1999: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1998: ¥3,900,000 (Direct Cost: ¥3,900,000)
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| Keywords | Psychobiological stress response / perceived stress / saliva level of free 3-methoxy-4-hydroxyphenyleglycol(MHPG) / anxiety disorder / anxiolytic drug / experimental-field study / mood / anxiety / メンタルストレステスト / 心臓血管系反応 / 精神神経免疫反応 / 日常生活ストレス / 性格特性 / 健康行動 / 作業成績 / ストループ干渉課題 / 唾液中MHPG含量 / 唾液分泌型免疫グロブリンA抗体 / メンタルストレス・テスト / メンタルワークロード / 唾液MHPG-SO_4含量 / 唾液免疫グロブリンA抗体産生量 / Raven'sマトリックス課題 / ストレス状態の評価 |
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| Research Abstract |
The modern transactional theories of stress and coping address that psychobiological stress responses emerge through an imbalance between demands (i.e., stressors) and psychosocial coping resources. This study is to examine the relationship among stress responsiveness, cognition, emotion and performance under acute and/or chronic stressful situations using the experimental-field paradigm.
1.As a measure of the levels of anxiety, mood, perceived stress in normal volunteers, we determined the saliva level of free 3-methoxy-4-hydroxyphenyleglycol (MHPG), using gas chromatography-mass spectrometry. The saliva level of free-MHPG was significantly correlated with score of tension-anxiety, depression and symptoms of stress in male, but not in female.
2.We measured free MHPG levels in the saliva and scored the levels of anxiety with Hamilton Anxiety Scale in anxious outpatients, before and after drug treatment with anxiolytic drugs such as alprazolam and tandospirone for 1 week. The saliva level of free-MHPG was significantly reduced by alppazolam treatment.
These findings suggest that the free Saliva MHPG level may be a useful indicators for assessing not only the level of perceived stress, but also the response to drug treatment for anxiety in anxious patients.
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