| Project/Area Number |
10460053
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
食品科学・栄養科学
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| Research Institution | GRADUATE SCHOOL OF AGRICULTURE, HOKKAIDO UNIVERSITY |
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Principal Investigator |
HARA Hiroshi Hokkaido Univ. Grad. School of Agr., Asso. Prof., 大学院・農学研究科, 助教授 (70198894)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZUKA Satoshi Hokkaido Univ. Grad. School of Agr., Inst., 大学院・農学研究科, 助手 (00271627)
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| Project Period (FY) |
1998 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1999: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1998: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | Colon Cancer / Aberrant Crypt Foci / Ionizong Irradiation / Chemical Carcinogen / Dietary Fiber / Intestinal Fermentation / Oxidized Lipids / 化学発がん剤 / 酸化DNA |
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| Research Abstract |
The aims of this study were to establish a model of colon cancer by ionizing radiation in rats and to compare the effects of dietary fiber feeding on cancer development with those in a chemically-induced colon cancer model. We first succeed to develop precancerous legion, aberrant crypt foci (ACF), in rat colonic mucosa by ionizing radiation. The properties of radiation-induced ACF were low frequency, but high multiplicity compared with the chemically induced ACF Feeding of a highly fermentable dietary fibers, sugarbeet fiber, suppressed ACF in the chemical model, but not the radiation model. In the chemical model, a low fermentable, soluble fiber prevent the development of colonic ACF just feeding fiber before, but not after a challenge of carcinogen. Also, a product of the colonic fermentation, butyric acid, prevented the development of ACF in the rat colon using the chemically-induced cancer model.
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