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The evaluation of myocardial angiogenesis by contrast echo-cardiogram

Research Project

Project/Area Number 10470169
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOsaka City University

Principal Investigator

YOSHIKAWA Junichi  Department of Internal Medicine and Cardiology, Osaka City University School of Medicine, Professor and Chairman, 医学部, 教授 (60275245)

Co-Investigator(Kenkyū-buntansha) OMURA Takashi  Department of Internal Medicine and Cardiology, Osaka City University, School of Medicine, Assistant Professor, 医学部, 助手 (70295707)
YOSHIYAMA Minoru  Department of Internal Medicine and Cardiology, Osaka City University, School of Medicine, Associate Professor, 医学部, 講師 (30240956)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1999: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1998: ¥8,800,000 (Direct Cost: ¥8,800,000)
KeywordsMyocardium / Ischemia / Echocardiography / gene expression / Ischemia / Echocardiography / Myocardiam / Echo cardiography / Gene expression
Research Abstract

Recently, microbubble can be used as a contrast agent and We try to detect the myocardial perfusion. We also try to make angiogenesis by gene therapy. The purpose of this study is to make angiogenesis by gene therapy and angiogenesis can be evaluated by contrast agent. In the first year, we succeeded to hace myocardila infarcted model in rat and mice. We analyzed signal transduction and mRNA expressions after myocardial infarction and evaluated morphological change and cardiac function by echocardiogram. In the second year, we could get gene transfer method by adeno virus vector and myocardial perfusion could be evaluated by contrast echocardiography. In the last year, we try to transfer gene to the myocardium in vivo model. This protocol is now on going. In clinical, we can detect myocardial perfusion by echo-contrast agent.
In experimental and clinical research, we will detect microcirculation and collateral flow in the myocardium near future.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (43 results)

All Other

All Publications (43 results)

  • [Publications] 大村崇: "Differences in time course of myocardial mRNA expression-"Basic Res Cardiol. 95. 316-23 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 大村崇: "Angiotensin blockade inhibits SIF DNA binding activities -"J Mol Cell Cardiol. 32. 23-33 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 秋岡要: "Prognostic value of Doppler transmittal -"Heart Vessels. 15. 53-60 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 平田久美子: "Reverse redistribition of thallium-201 myocardial -"Jpn Circ J. 64. 345-51 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 市場直也: "Images in cardiovascular medicine."Circulation. 101. 1754-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小林芳樹: "Left ventricular electrome chanical mapping -"Circulation. 102. E25-6 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akioka K, Takeuchi K, Yanagi S, Hirota K, Sakamoto K, Yoshimura T, Toda I, Yoshikawa J.: "Prognostic value of Doppler transmittal flow patterns and cardiac natriuretic peptides in patients with chronic congestive heart failure admitted for episodes of acute decompensation."Heart Vessels.. 15. 53-60 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirata K, Yamagishi H, Tani T, Sakanoue Y, Akioka K, Takeuchi K, Yoshikawa J, Ochi H.: "Reverse redistribution of thallium-201 myocardial single photon emission tomography and contractile reserve."Jpn Circ J.. 64. 345-51 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ichiba N, Shimada K, Hirose M, Kobayashi Y, Hirata K, Sakanoue Y, Toda I, Teragaki M, Akioka K, Takeuchi K, Yoshikawa J.: "Images in cardiovascular medicine. Plaque rupture causing spontaneous coronary artery dissection in a patient with acute myocardial infarction."Circulation.. 101. 1754-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kobayashi Y, Shimada K, Yamagishi H, Ehara S, Nakamura Y, Takeuchi K, Yoshikawa J.: "Left ventricular electromechanical mapping in stunned myocardium."Circulation.. 102. E25-6 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Omura T, Yoshiyama M, Takeuchi K, Hanatani A, Kim S, Yoshida K, Izumi Y, Iwao H, Yoshikawa J.: "Differences in time course of myocardial mRNA expression in non-infarcted myocardium after myocardial infarction."Basic Res Cardiol.. 95. 316-23 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Omura T, Yoshiyama M, Takeuchi K, Kim S, Iwao H, Yamagishi H, Toda I, Teragaki M, Akioka K, Yoshikawa J.: "Angiotensin blockade inhibits SIF DNA binding activities via STAT3 after myocardial infarction."J Mol Cell Cardiol.. 32. 23-33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toda I, Teragaki M, Nishida Y, Kobayashi Y, Shimada K, Yoshiyama M, Akioka K, Takeuchi K, Yoshikawa J.: "[Prediction of restenosis after percutaneous transluminal coronary angioplasty using coronary flow reserve. Kansai Doppler Guide Wire Study Group]."Cardiol.. 35. 165-73 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamagishi H, Akioka K, Hirata K, Sakanoue Y, Toda I, Yoshiyama M, Teragaki M, Takeuchi K, Yoshikawa J, Ochi H.: "A reverse flow-metabolism mismatch pattern : a new marker of viable myocardium with greater contractility during dobutamine stress than myocardium with a flow-metabolism mismatch pattern."Jpn.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Akioka K,Takeuchi K,Yanagi S,Hirota K,Sakamoto K,Yoshimura T,Toda I,Yoshikawa J.: "Prognostic value of Doppler transmittal flow patterns and cardiac natriuretic peptides in patients with chronic congestive heart failure admitted for episodes of acute decompensation."Heart Vessels.. 15. 53-60 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hirata K,Yamagishi H,Tani T,Sakanoue Y,Akioka K,Takeuchi K,Yoshikawa J,Ochi H.: "Reverse redistribution of thallium-201 myocardial single photon emission tomography and contractile reserve."Jpn Circ J.. 64. 345-51 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ichiba N,Shimada K,Hirose M,Kobayashi Y,Hirata K,Sakanoue Y,Toda I,Teragaki M,Akioka K,Takeuchi K,Yoshikawa J.: "Images in cardiovascular medicine. Plaque rupture causing spontaneous coronary artery dissection in a patient with acute myocardial infarction."Circulation.. 101. 1754-5 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kobayashi Y,Shimada K,Yamagishi H,Ehara S,Nakamura Y,Takeuchi K,Yoshikawa J.: "Left ventricular electromechanical mapping in stunned myocardium."Circulation.. 102. E25-6 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Omura T,Yoshiyama M,Takeuchi K,Hanatani A,Kim S,Yoshida K,Izumi Y,Iwao H,Yoshikawa J.: "Differences in time course of myocardial mRNA expression in non-infarcted myocardium after myocardial infarction."Basic Res Cardiol.. 95. 316-23 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Omura T,Yoshiyama M,Takeuchi K,Kim S,Iwao H,Yamagishi H,Toda I,Teragaki M,Akioka K,Yoshikawa J.: "Angiotensin blockade inhibits SIF DNA binding activities via STAT3 after myocardial infarction."J Mol Cell Cardiol.. 32. 23-33 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Toda I,Teragaki M,Nishida Y,Kobayashi Y,Shimada K,Yoshiyama M,Akioka K,Takeuchi K,Yoshikawa J.: "[Prediction of restenosis after percutaneous transluminal coronary angioplasty using coronary flow reserve. Kansai Doppler Guide Wire Study Group]."J Cardiol.. 35. 165-73 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamagishi H,Akioka K,Hirata K,Sakanoue Y,Toda I,Yoshiyama M,Teragaki M,Takeuchi K,Yoshikawa J,Ochi H.: "A reverse flow-metabolism mismatch pattern : a new marker of viable myocardium with greater contractility during dobutamine stress than myocardium with a flow-metabolism mismatch pattern."Jpn Circ J.. 64. 659-66 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamagishi H,Toda I,Akioka K,Hirata K,Yoshiyama M,Teragaki M,Takeuchi K,Yoshikawa J,Ochi H.: "Effects of metabolically ischemic, but viable, myocardium on QT dispersion in patients with acute myocardial infarction : a study with resting I-123-BMIPP/thallium-201 myocardial single-photon emission computed tomography."Jpn Circ J.. 64. 572-8 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamagishi H,Akioka K,Hirata K,Sakanoue Y,Toda I,Yoshiyama M,Teragaki M,Takeuchi K,Yoshikawa J,Ochi H.: "Effects of preinfarction angina on myocardial injury in patients with acute myocardial infarction : a study with resting 123I-BMIPP and 201T1 myocardial SPECT."J Nucl Med.. 41. 830-6 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hirata K.,Yamagishi H.,Akioka K.,Yoshiyama M.,Toda I.,Teragaki M.,Takeuchi K.,Yoshikawa J.,Minoru Y.,Iku T.,Masakazu T.: "A case of diffuse pulmonary arteriovenous fistula [published erratum appears in Jpn Circ J 1999 Jul,63(7):576]"Jpn Circ J. 63(6). 499-501 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hirose M.,Shimada K.,Sakanoue Y.,Hirata K.,Takeuchi K.,Yoshikawa J.: "Usefulness of newly designed pigtail catheter with multiple side holes by reducing incidence of ventricular ectopy"Catheter Cardiovasc Interv. 48(2). 220-225 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Omura T.,Yoshiyama M.,Shimada T.,Shimizu N.,Kim S.,Iwao H.,Takeuchi K.,Yoshikawa J.: "Activation of mitogen-activated protein kinases in in vivo ischemia/ reperfused myocardium in rats"J Mol Cell Cardiol. 31(6). 1269-1279 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sakamoto T.,Kawarabayashi T.,Taguchi H.,Tanaka A.,Nishida Y.,Shimada K.,Yoshikawa J.: "Intravascular ultrasound-guided balloon angioplasty for treatment of instent restenosis"Catheter Cardiovasc Interv. 47(3). 298-303 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimada K.,Watanabe H.,Hosoda K.,Takeuchi K.,Yoshikawa J.: "Effect of red wine on coronary flow-velocity reserve [letter]"Lancet. 354(9183). 1002 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takemoto Y.,Yoshiyama M.,Takeuchi K.,Omura T.,Komatsu R.,Izumi Y.,Kim S.,Yoshikawa J.: "Increased JNK, AP-1 and NF-kappa B DNA binding activities in isoproterenolinduced cardiac remodeling"J Mol Cell Cardiol. 31(11). 2017-2030 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamagishi H.,Akioka K.,Takagi M.,Tanaka A.,Takeuchi K.,Yoshikawa J.,Ochi H.: "Exercise four hour redistribution thallium-201 single photon emission computed tomography and exercise induced ST segment elevation in detecting the viable myocardium in patients with acute myocardial infarction"Heart. 81(1). 17-24 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamamuro A.,Yoshida K.,Hozumi T.,Akasaka T.,Takagi T.,Kaji S.,Kawamoto T.,Yoshikawa J.: "Noninvasive evaluation of pulmonary capillary wedge pressure in patients with acute myocardial infarction by deceleration time of pulmonary venous flow velocity in diastole"J Am Coll Cardiol. 34(1). 90-94 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoshiyama M.,Takeuchi K.,Omura T.,Izutani S.,Nakamura Y.,Akioka K.,Kim S.,Iwao H.,Yoshikawa J.: "Effect of diltilazem on cardiac remodeling in rats assessed by Doppler echocardiography and mRNA expression"Cardiovasc Drugs Ther. 13(3). 249-258 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoshiyama M.,Takeuchi K.,Omura T.,Kim S.,Yamagishi H.,Toda I.,Teragaki M.,Akioka K.,Iwao H.,Yoshikawa J.: "Effects of candesartan and cilazapril on rats myocardial infarction assessed by echocardiography"Hypertension. 33(4). 1961-1968 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] The Effect of vasopressin V1-and V2-receptor antagonists on hemodynamics in early and late phase after myocardial infarction in rats: "Fujita,H.,Yoshiyama,M.,Takeuchi,K.,Omura,T.,Yamagishi,H.,Iwao,H.,Miura,K.and Yoshikawa,J." Japanese Journal of Pharmacology,Oct. 78(2). 229-232 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Assessment of cardiac function and gene expression at an early phase after myocardial infarction: "Hanatani,A.,Yoshiyama,M.,Kim,S.,Omura,T.,Ikuno,Y.,Takeuchi,K.,Iwao,H.and Yoshikawa,J." Jpn Heart J. 39(3). 375-88 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Angiotensin II type 1-receptor antagonist candesartan cilexitil prevents left ventricular dysfunction in myocardial infarcted rats: "Hanatani,A.,Yoshiyama,M.,Takeuchi,K.,Kim,S.,Nakayama,K.,Omura,T.,Iwao,H.and Yoshikawa,J." Japanese Journal of Pharmacology.Sep. 78(1). 45-54 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Long acting calcium antagonist amlodipine prevents left ventricular remodeling after myocardial infarction in rats: "Shimada,T.,Yoshiyama,M.,Takeuchi,K.,Omura,T.,Takemoto,Y.,Kim,S.,Iwao,H.and Yoshikawa,J." Cardiovasc Res. 37(3). 618-26 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Doppler echocardiographic assessment and cardiac gene expression analysis of the left ventricle in myocardial infarcted rats: "Shimizu,N.,Yoshiyama,M.,Takeuchi,K.,Hanatani,A.,Kim,S.,Omura,T.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(6). 436-42 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats: "Shimizu,N.,Yoshiyama,M.,Omura,T.,Hanatani,A.,Kim,S.,Takeuchi,K.,Iwao,H.and Yoshikawa,J." Cardiovasc Res. 38(1). 116-24 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A case of dobutamine-induced coronary arterial spasm with ST-segment elevation: "Yamagishi,H.,Watanabe,H.,Toda,I.,Yoshiyama,M.,Akioka,K.,Teragaki,M.,Takeuchi,K.and yoshikawa,J." Jpn Circ J. 62(2). 150-1 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Effect of cilazapril on ventricular remodeling assessed by Doppler-echocardiographic assessment and cardiac gene expression: "Yoshiyama,M.,Takeuchi,K.,Hanatani,A.,Shimada,T.,Takemoto,Y.,Shimizu,N.,Omura,T.,Kim,S.,Iwao,H.and Yoshikawa,J." Cardiovasc Drugs Ther. 12(1). 57-70 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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