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Plasticity of Early Human Brain

Research Project

Project/Area Number 10470220
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTottori University

Principal Investigator

TAKESHITA Kenzo  Tottori University Faculty of Medicine, Professor, 医学部, 教授 (90037375)

Co-Investigator(Kenkyū-buntansha) EHARA Hiroaki  Tottori Univ.Fac.of Med., Research Associate., 医学部, 助手
MAEGAKI Yoshihiro  Tottori Univ.Fac.of Med., Research Associate., 医学部・附属病院, 助手 (80252849)
前岡 幸憲  鳥取大学, 医学部・附属病院, 助手 (30273890)
洲崎 一郎  鳥取大学, 医学部・附属病院, 助手 (80294320)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsPlasticity / Early brain / Human brain / Newborn / Fetus / 先天性脳障害児
Research Abstract

The several investigations on the mechanism or pathogenesis of reorganization from early brain lesions damaged in fetal and neonatal periods were done in the human patients. The investigations were done clinically under the use of neurophysiological, neuro-immunological and neurobiological methods. Especially, transcranial magnetic stimulation was useful for the research. We could finally conclude as follows ; (1) the brain lesions early in fetal development were less harmful than the lesions acquired later. However, (2) the possible mechanisms of the reorganization from damaged brain lesions in the developing brain were not simple but more complicated. The results from neuro-immunological investigations have also demonstrated the possibility of participation in mechanism of cortical plasticity. However it was not so clear results. we have to investigate still more for getting evidence by changing to other methodology.

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] Maegaki Y, et al.: "Central motor reorganization in CP patients with bilateral cerebral lesions."Pediatr Res.. 45. 559-567 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mauka Y,Takeshita K: "Excitability recovery curves of blink reflexs in patients with athetotic CP."Electromyogr clion Neuroplysiol. 39. 79-85 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koedo T,TakeshitaK.: "Low interhemispheric and high intrahemispheric EEG coherence in migraine"Headaohe. 39. 280-286 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tigoshima M.Takeshita K: "Cellular senescence of angiofibroma stroma cells from patients with TS."Brain Dev.. 21. 184-191 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Maegaki Y. et al.: "Unilateral involuntary movement associated with streptococcal infection"Neuropediatrics. 31. 70-74 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Maegaki Y, Yamamoto T, Takeshita K.: "Plasticity of central motor and sensory pathways in a case of unilateral extensive cortical dysplasia."Neurology. 45. 2255-2261 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzaki I, Hara T, Takeshita K.: "Elevated nerve growth factor levels in cerebrospinal fluid associated with progressive cortical atrophy."Neuropediatrics. 28. 268-271 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Suzaki I, Hara T, Maegaki Y, Takeshita K.: "Nerve growth factor levels in cerebrospinal fluid from patients with neurologic disorders."J Child Neurol. 12. 205-207 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Maegaki Y, Maeoka Y, Yoshino K, Takeshita K.: "Mechanisms of central motor reorganization in pediatric hemiplegic patienta."Neuropediatr. 28. 168-174 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Maegaki Y, Maeoka Y, Takeshita K.: "Facilitation of ipsilateral motor pathways during recovery from hemiplegia in two adolescent patients."Eur J Paediatr Neurol. 2/3. 79-84 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto T, Hara T, Takeshita K.: "Abnormal expansion of peripheral γ δ T cells in patients with neurologic disorders."Brain, Behavior, and Immunity. 11. 157-166 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koeda T, Inoue M, Takeshita K.: "Constructional dyspraxia in preterm diplegia : isolation from visual and visual perceptual impairments."Acta Paediatr. 86. 1068-1073 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto T, Koeda T, Maegaki Y, Tanaka C, Takeshita K.: "Bilateral opecular syndrome caused by perinatal difficulties."Eur J Paediatr Neurol. 2/3. 73-77 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshimura M, Saji M.: "Transsynaptic cell death of neurons following striatopallidal lesions does not occur in substantia nigra pars reticulata in developing rats."Dev Brain Res. 105. 25-33 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tanaka C, Maegaki Y, Koeda T, Ohta S, Takeshita K.: "Successful treatment of progressive myoclonic epilepsy with TRH."Pediatr Neurol. 18. 442-444 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Maeoka Y, Maegaki Y, Takeshita K.: "Excitability recovery curves of blink reflexs in patients with athetotic cerebral palsy."Electromyogr clin Neurophysiol. 39. 79-85 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Maegaki Y, Maeoka Y, Eda I, Koeda T, Takeshita.: "Central motor reorganization in cerebral palsy patients with bilateral cerebral lesions."Peidatr Res. 45. 559-567 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Toyoshiam M, Ohno K, Katsumoto T, Maki H, Takeshita K.: "Cellular senescence of angiofibroma stroma cells from patients with tuberous sclerosis."Brain Dev. 21. 184-191 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Koeda T, Takeshima T, Matsumoto M, Nakashima K, Takeshita K.: "Low interhemispheric and high intrahemispheric EEG coherence in migranne"Headache. 39. 280-286 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Maegaki Y, Akaboshi S, Inagaki M, Takeshita K.: "Unilateral involuntary movement associated with streptococcal infection : Neurophysiological investigation."Neuopediatrics. 31. 70-74 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Maegaki Y. et al.: "Central motor reorganization in cerebral palsy patients with bilateral cerebral lesions."Pediatr Res. 45. 559-567 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Toyoshima M,Takeshita K. et al.: "Cellular senescence of angiofibroma stroma cells from patients with tuberous sclerosis."Brain Dev. 21. 184-191 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Koeda T,Takeshita K. et al.: "Low interhemispheric and high intrahemispheric EEG coherence in migraine."Headache. 39. 280-286 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maegaki Y. et al: "Unilateral involuntary movement associated with streptococcal infection :"Neuropediatr. 31. 70-74 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maegaki Y,Maeoka Y,et al.: "Central motor re-organization in cerebral palsy"Pediatric Research. 45. 559-567 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Zhang H,Yamamoto T,et al.: "Novel TSC2 mutation in patient with pulmonary TS."Am.J.Med.Genet.. 82. 368-370 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toyoshima M,Ohno K,et al.: "Cellular senescence of angiofibroma stroma cells"Brain Dev.. 21. 184-191 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Zhang H,Nanba E,et al.: "Mutational analysis of TSC1 and TSC2 genes in TS."J.Hum.Genet.. 44. 391-396 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanaka C,Maegaki Y,et al.: "Successful treatment of pcogressive myoclonus epilepsy"Pediatr Neurolo. 18. 442-444 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Koeda T,Takeshita K,et al.: "Low interhemispheric and high interhemispheric EEG"Headache. 39. 280-286 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeshita K,et al.: "Construction dyspraxia in preterm diplegia." Acta Paediatrica. 86. 1068-1073 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Maegaki Y,et al.: "Mechanisms of central motor pathways recognition・・・" Neuropediatrics. 28. 168-174 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Maegaki Y,et al.: "Facilitaion of ipsilateral motor pathways during・・・" Eur J Paediatr Neurol. 2. 79-84 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Maegaki Y,et al.: "Magnetic stimulation of the lumbosacral vertebral・・" Electroencephalogr Clin Neurophysiol. 105. 102-108 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takeshita K,et al.: "Abnronmal expansion of peripheral gamma delta T cell" Brain,Behavior and Immunity. 11. 157-166 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suzaki I,et al.: "Evaluated nerve growth factor levels in cerebrospinal" Neuropediatr. 28. 268-271 (1997)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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