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Elucidation of role of vascular local hormones on endothelial differentiation by developmental cell bilology and its application to vascular regeneration therapy.

Research Project

Project/Area Number10470227
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ITOH Hiroshi  Kyoto University Graduate School of Medicine, Medicine and Clinical Science, Assistant Professor, 医学研究科, 助手 (40252457)

Co-Investigator(Kenkyū-buntansha) HOSODA Kiminori  Hosoda, Kiminori Kyoto University, Graduate School of human and Environment Studies, Assistant Professor, 人間・環境学研究科, 助手 (40271598)
UMEMURA Kazuo  Hamamatsu University of Medicine, Professor, 医学部, 教授 (40232912)
OGAWA Minetaro  Kyoto University Graduate School of Medicine, Medicine and Clinical Science, Assistant Professor, 医学研究科, 助手 (70194454)
Project Period (FY) 1998 – 1999
Project Status Completed(Fiscal Year 1999)
Budget Amount *help
¥7,600,000 (Direct Cost : ¥7,600,000)
Fiscal Year 1999 : ¥3,000,000 (Direct Cost : ¥3,000,000)
Fiscal Year 1998 : ¥4,600,000 (Direct Cost : ¥4,600,000)
Keywordsendothelial cells / vascular smooth muscle cells / natriuretic peptides / ES cells / atherosclerosis / VEGF / transgenic mice / adenovirus / cGMP / 前駆細胞
Research Abstract

Endothelial dysfunction plays the pivotal role in proliferative vascular diseases. Molecular understanding of endothelial cell function leads to vascular regeneration therapy. This research project aims at elucidation of the pathophygiological significance of vascular local hormones, especially natriuretic peptides, mainly by the approach of developmental cell biology.
1. We demonstrated that VEGF (vascular endothelial growth factor) modulates endothelial secretion of vascular local hormones, including CNP (C-type natriuretic peptide) and reported that VEGF expression is augmented in human coronary atherosclerotic lesions. VEGF and its receptor (Flk-1,flt-1) expression were detected in activated endothelial cells, de-differentiated vascular smooth muscle cells and macrophages. Oxidized LDL up-regulated VEGF expression in cultured human coronary endothelial cells.
2. Using cell sorting technique, we isolated Flk-1 positive mouse ES cells, cultured them on collagen IV coated dishes with VEGF and made them differentiated into endothelial cells. In collagen gel 3D culture, we also succeeded in tube formation with Flk-1 ES cells. We also clarified the gene expression of CNP and its receptor, Guanylate Cyclase B during the course of differentiation of ES cells to embryoid body. We reported CNP expression in rat embryo and neonatal lung tissue.
3. We constructed CNP cDNA recombinant adenovirus and using the CNP adenovirus demonstrated that over-expression of CNP in balloon-injured rabbit femoral artery resulted in suppression of neointimal formation, re-differentiation of vascular smooth muscle cells and acceleration of re-endothelialization. We also succeeded in cloning human cGMP-dependent protein kinase(cGK)type Iα and developed cGK transgenic mice(cGK. Tg). In cGK. Tg, strong cGK expression was detected in the brain, heart, blood vessels and skeletal muscle. Using the cGK. Tg, we demonstrated that cGK can act for vascular protection in photo-chemical injury model.

Report

(3results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report

Research Products

(77results)

All Other

All Publications

  • [Publications] K. Masatsugu et al.: "Physiologic shear stress suppresses endothelin-converting enzyme-l expression in vascular endothelial cells"J. Cardiovasc. Pharmacol.. 31 suppl 1. S42-S45 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Saito et al.: "Oxidative stress suppresses the endothelial secretion of endothelin"J. Cardiovasc. Pharmacol.. 31 suppl 1. S45-S47 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Igaki et al.: "Effects of intravenously administered C-type natriuretic peptide in humans- -Comparison with atrial natriuretic peptide"Hypertens. Res.. 21. 7-13 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.Suga et al.: "Regulation of endothelial production of C-type natriuretic peptide bu interaction between endothelial cells and macrophages"Endocrinology. 139. 1920-1926 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Suda et al.: "Skeletal overgrowth in transgenic mice that overzpress brain natriuretic peptide"Proc. Natl. Acad. Sci. U.S.A.. 95. 2337-2342 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N.Azuma et al.: "The significance of the Trp 64 Arg mutation of the b3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects"Metabolism. 47. 456-460 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Numata et al.: "Immunoradiometric assay for the N-termnal fragement of proatrial natriuretic peptide in human plasma"Clinical Chemistry. 44. 1008-1013 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Harada et al.: "Interacton of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture"J. Cardiovasc. Pharmacol.. 31suppl. 1. 2357-S359 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G.Takemura et al.: "Expression of atrial and brain natriuretic peptides and their genes in hearts of patients with cardiac amyloidosis"J. Am. Coll. Cardiol.. 31. 2654-2665 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J.Yamashita et al.: "Identification of cis-element of the human endothekin-A receptor gene and inhibition of the gene expression by the decoy stratgy"J. Biol. Chem.. 273. 15993-15999 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Nanno et al.: "Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress"Prenat. Neonat Med.. 3. 222-226 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Nanno et al.: "Nitric oxide metabolite concentrations in maternal plasma decrease during parturition: possible transient down-regulation of nitric oxide synthesisi"Molecular Human Reproduction. 4. 609-616 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Inoue et al.: "Vascular endothelial growth factor (VECF) expression in human coronary atherosclerotic lesions : Possible pathophysiological significance of VEGF in progression of atheroselerosis"Circulation. 98. 2108-2116 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.miyamoto et al.: "Endothelial nitric oxide synthase gene is positively associated with essential hypertension"Hypertension. 32. 3-8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J.Matuda et al.: "Increased adipose expression of uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes"Diabetes. 47. 1809-1814 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Yamaguchi et al.: "Effect of neutral endopeptidase inhibitions on the natriuresis and renal clearance of atrial natriuretic peptide in perfused rat kidney"Pharmaceutical Research. 15. 1499-1502 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Doyama et al.: "Expression and distribution of brain natriuretic peptide in human right atria"J. Am. Coll. Cardiol.. 32. 1832-1838 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Itoh et al.: "Hypertension and insulin resisitance-The role of peroxisome proliferator-activated receptor-γ-"Clin. Exp. Pharmacol . P .. 26. 558-560 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.tanaka et al.: "Down-regulation of peroxisome proliferator-activated receptor γ expression by inflammatory cytokines and its reversal by thiazolidinediones"Diabetologia. 42. 702-710 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J.Ozaki et al.: "Enzymatic inactivation of major circulating forms atrial and brain natriuretic peptides"Eur.J.Pharmacol.. 370. 307-312 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Itoh et al.: "Vascular stress response and endothelial vasoactive factors for vascular remodeing"Diabetes Res.Clin. Pr.. 45. 83-88 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Nakanishi et al.: "Expression of C-type natriuretic peptide during development of rat lung"Am. J. Physiol.. 277. L1-L7 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T-H.Chun et al.: "Oxidative stress auguments secretion of endothelium-derived relaxing peptides,C-type natriuretic peptide and adrenomedullin"J. Hpertens.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N.Tamura et al.: "Cardiac fibrosis in mice lacking brain natriuretic peptide"Proc. Natl. Acad. Sci. U.S.A.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N.Sawada et al.: "Inhibition of Rho-associated kinase results in suppression of neinimal formation of balloon-injured arteries"Circulation. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Masatsugu et al.: "Physiologic shear stress suppresses endothelin-converting enzyme-1 expression in vascular endothelial cells."J. Cardiovasc. Pharmacol.. 31 Suppl. 1. S42-S45 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Saito et al.: "Oxidative stress suppresses the endothelial secretion of endothelin."J. Cardiovasc. Pharmacol.. 31 Suppl. 1. S45-S47 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Igaki et al.: "Effects of intravenously administered C-type natriuretic peptide in humans-Comparison with atrial natriuretic peptide."Hypertens. Res.. 21. 7-13 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Suga et al.: "Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages."Endocrinology. 139. 1920-1926 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Suda et al.: "Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide."Proc. Natl. Acad. Sci. U. S. A.. 95. 2337-2342 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N. Azuma et al.: "The significance of the Trp 64 Arg mutation of the b3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects."Metabolism. 47. 456-460 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Numata et al.: "Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptide in human plasma."Clinical Chemistry. 44. 1008-1013 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Harada et al.: "Interaction of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture."J. Cardiovasc. Pharmacol.. 31 Suppl. 1. S357-S359 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G. Takemura et al.: "Expression of atrial and brain natriuretic peptides and their genes in hearts of patients with cardiac amyloidosis."J. Am. Coll. Cardiol.. 31. 2654-2665 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J. Yamashita et al.: "Identification of cis-element of the human endothelin-A receptor gene and inhibition of the gene expression by the decoy strategy."J. Biol. Chem.. 273. 15993-15999 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Nanno et al.: "Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress."Prenat. Neonat Med.. 3. 222-226 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Nanno et al.: "Nitric oxide metabolite concentrations in maternal plasma decrease during parturition : possible transient down-regulation of nitric oxide synthesis."Molecular Human Reproduction. 4. 609-616 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Inoue et al.: "Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions : Possible pathophysiological significance of VEGF in progression of atherosclerosis."Circulation. 98. 2108-2116 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J. Matsuda et al.: "Increased adipose expression of uncoupling protein-3 gnene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes."Diabetes. 47. 1809-1814 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Yamaguchi et al.: "Effect of neutral endopeptidase inhibition on the natriuresis and renal clearance of atrial natriuretic peptide in perfused rat kidney."Pharmaceutical Research. 15. 1499-1502 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Doyama et al.: "Expression and distribution of brain natriuretic peptide in human right atria."J. Am. Coll. Cardiol.. 32. 1832-1838 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Itoh et al.: "Hypertension and insulin resistance-The role of peroxisome proliferator-activated receptor-γ-"Clin. Exp. Pharmacol. P.. 26. 558-560 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T. Tanaka et al.: "Down-regulation of peroxisome proliferator-activated receptor γ expression by inflammatory cytokines and its reversal by thiazolidinediones."Diabetologia. 42. 702-710 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J. Ozaki et al.: "Enzymatic inactivation of major circulating forms atrial and brain natriuretic peptides."Eur. J. Pharmacol.. 370. 307-312 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Itoh et al.: "Vascular stress response and endothelial vasoactive factors for vascular remodeling."Diabetes Res. Clin. Pr. 45. 83-88 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Nakanishi et al.: "Expression of C-type natriuretic peptide during development of rat lung."Am. J. Physiol.. 277. L1-L7 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T-H. Chun et al.: "Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin."J. Hypertens.. in press. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N. Tamura et al.: "Cardiac fibrosis in mice lacking brain natriuretic peptide."Proc. Natl. Acad. Sci. USA. in press. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] N. Sawada et al.: "Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries."Circulation. in press. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Miyamoto et al.: "Endothelial nitric oxide synthase gene is positively associated with essential hypertension."Hypertension. 32. 3-8 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Itoh et al.: "Hypertension and insulin resistance-The role of peroxisome proliferator-activated receptor-γ"Clin. Exp. Pharmacol. P.. 26. 558-560 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Tanaka et al.: "Down-regulation of peroxisome proliferator-activated receptor γ expression by inflammatory cytokines and its reversal by thiazolidinediones"Diabetologia. 42. 702-710 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] J.Ozaki et al.: ""Enzymatic inactivation of major circulating forms atrial and brain natriuretic peptides"Eur. J. Pharmacol.. 370. 307-312 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Itoh et al.: "Vascular stress response and endothelial vasoactive factors for vascular remodeling"Diabetes Res. Clin. Pr.. 45. 83-88 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Nakanishi et al.: "Expression of C-type natriuretic peptide during development of rat lung"Am. J. Physiol.. 277. L1-L7 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T-H.Chun et al.: "Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin"J. Hypertens.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] N.Tamura et al.: "Cardiac fibrosis in mice lacking brain natriuretic peptide"Proc. Natl. Acad. Sci. USA. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] N.Sawada et al.: "Inhibition of Rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries"Circulation. (ih press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Masatsugu et al.: "Physiologic shear stress suppresses endothelin-converting enzyme-1 expression in vascular endothelial cells." J.Cardiovasc.Pharmacol.31 SUPPL 1. S42-S45 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Saito et al.: "Oxidative stress suppresses the endothelial secretion of endothelin." J.Cardiovasc.Pharmacol.31 SUPPL 1. S45-S47 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Igaki et al.: "Effects of intravenously administered C-type natruretic peptide in humans--Comparison with atrial natriuretic peptide." Hypertens.Res.21. 7-13 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] S.Suga et al.: "Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages." Endocrinology. 139. 1920-1926 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Suda et al.: "Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide." Proc.Natl.Acad.Sci.U.S.A.95. 2337-2342 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] N.Azuma et al.: "The significance of the Trp 64 Arg mutation of the b3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects." Metabolism. 47. 456-460 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Inoue et al.: "Vacular endothelial growth factor(VEGF)expression in human coronary atherosclerotic lesions:Possible pathophysiological significance of VEGF in progression of atherosclerosis." Circulation. 98. 2108-2116 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Miyamoto et al.: "Endothelial nitric oxide synthase gene is positively associated with essential hypertension." Hypertension. 32. 3-8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] J.Matsuda et al.: "Increased adipose expression of uncoupling protein-3 gnene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes." Diabetes. 47. 1809-1814 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Yamaguchi et al.: "Effect of neutral endopeptidase inhibition of the natriuresis and renal clearance of atrial natriuretic peptide in perfused rat kidney." Pharmaceutical Research. 15. 1499-1502 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Doyama et al.: "Expression and distribution of brain natruiretic peptide in human right atria." J.Am.Coll.Cardiol.32. 1832-1838 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Itoh et al.: "Hypertension and insulin resistance-The role of peroxisome proliferator-activated receptor-γ(PPARγ)-" Clinical and Experimental Pharmacology and Physiology. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y.Numata et al.: "Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptide in human plasma." Clinical Chemistry. 44. 1008-1013 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Harada et al.: "Interaction of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture." J.Cardiovasc.Pharmacol.31 SUPPL 1. S357-S359 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] G.Takemura et al.: "Expression of atrial and brain natriuretic peptides and their genes in hearts of patients with cardiac amyloidosis." J.Am.Coll.Cardiol.31. 254-265 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] J.Yamashita et al.: "Identification of cis-element of the human endothelin-A receptor gene and inhobition of the gene expression by the decoy strategy." J.Biol.Chem.273. 15993-15999 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Nanno et al.: "Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress." Prenat.Neonat Med.3. 222-226 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Nanno et al.: "Nitric oxide metabolite concentrations in maternal plasma decrease during parturition: possible transient down-regulation of nitric oxide synthesis." Molecualr Human Reproduction. 4. 609-616 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Tanaka et al.: "Down-regulation of peroxisome proliferator-activated receptorg expression by inflammatory cytokines and its reversal by thiazolidinediones." Diabetologia. (in press). (1999)

    • Related Report
      1998 Annual Research Report

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Published : 1998-04-01   Modified : 2016-04-21  

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