|Budget Amount *help
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1999: ¥3,400,000 (Direct Cost: ¥3,400,000)
|Keywords||Indolo [2, 3-α] carbazole / 2,2'-Biindolyl / 1-Acetyl-2,3-dihydro-2,2'-biindolyl / 3-Acetoxy-2,2'-biindolyl / N-Glycosyl 2,2'-biindolyls / 1-Methoxyindole / 1-Hydroxyindole / 6-Cyano-5-methoxyindolo [2,3-α] carbazole / 2,2´-ビスインドール / 2,2'-ビスインドール|
1. Study toward Indolo [2,3-α] carbazoles
Important building blocks such as 2,2'-biindolyl, 3-acetoxy-2,2'-biindolyl, 1-acetyl-2,3-dihydro-2,2'-biindolyl were prepared by our own new reactions from industrially available chemical, indigo. Utilizing these compounds as starting materials, four short step total synthetic routes to an antibiotic, 6-cyano-5-methoxyindolo [2,3-α] carbazole, were developed.
N-Glycosyl 2,2'-biindolyls were also prepared and found to be excellent substrates for producing N-glycosylindolo [2,3-α] carbazoles.
Above methods are widely applicable for the syntheses of various kinds of indolo [2,3-α] carbazoles.
2. The Chemistry of 1-Hydroxyindoles
2,2'-Biindolyl was also prepared through oxidative coupling of lithium 1-methoxyindol-2-yl and converted to indolo [2,3-α] carbazoles which constituted the fifth synthetic route.
1-Methoxyindoles are prepared from 1-hydroxyindoles, which are new compounds in indole chemistry. The chemistry of 1-hydroxyindoles was widely examined and found to be rich in a lot of new findings that were not expected from thusfar known indole chemistry.
A frontier in indole chemistry is now open.