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ANALYSIS OF MOLECULAR MECHANISMS UNDERLYING CORTICAL ALIGNMENT

Research Project

Project/Area Number 10480213
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionINSTITUTE FOR PHYSICAL AND CHEMICAL RESEARCH (RIKEN) (1999-2000)
Kochi Medical School (1998)

Principal Investigator

OGAWA Masaharu  RIKEN, LABORATORY CELL CULTURE DEVELOPMENT., LABORATORY HEAD, 細胞培養技術研究開発チーム, チームリーダー(研究職) (50111951)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Kazunori  JIKEI UNIVERSITY, SCHOOL OF MEDICINE, INSTITUTE OF DNA MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (90280734)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥11,900,000 (Direct Cost: ¥11,900,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥8,100,000 (Direct Cost: ¥8,100,000)
KeywordsREELIN / DAB1 / CNR / CEREBRAL CORTEX / LAYERING / REELER / YOTARI / CAJAL-RETZIUS CELLS / 脳皮質 / 層構造 / 細胞移動 / リーリンシグナルカスケード / リーラー / Cdk5 / ニューロン産生 / リーリン / Disabled-1 / ヨタリ / Reelin / CR-50 / m-Dab-1 / Cerebe llum / Purkinje cells / Granule cells / cell positioning / migration
Research Abstract

The present research aim is to provide better understanding the cellular and molecular mechanisms of cortical development, especially the interplay of reelin signal cascade with cortical cell's alignment. In the neurological mutant mice reeler, the various classes of cortical neurons are generated and complete their migration at the normal time, however, the cellular pattern in the radial dimension is distorted, i.e., the cortical lamination is roughly inverted. We showed experimentally that Reelin, the product of the reeler gene (Reln) and secreted from the Cajal-Retzius cells, provides an instructive signal for migrating cortical neurons to align at appropriate location ill developing cortex. Using a unique antibody CR-50 which recognizes Reelin, we showed that Reelin binds each other to form a huge protein complex and suggested that this assembly formation is critical for its function. The reeler phenotype is also observed in yotari mutant mice lacking the mdab1 gene which encodes s … More ignal transduction-associated protein Dab1. We have found that the yotari mutation is caused by a replacement of dab1 gene sequence with a long interspersed nuclear element (L1) fragment. Unlike Reelin, Dab1 is expressed in the cortical plate neurons, resides in the cytoplasm and interacts with tyrosine kinases of the Src family. In addition, phosphorylation of Dab1 is decreased in reeler, but increased when Reelin is added to cortical cell cultures. These observations indicated the presence of the Reelin receptors in the cell membrane of the cortical plate neurons that sense the extracellular Reelin, couple with tyrosine kinases and relay this signal to the cell via Dab1. Yagi group had previously showed that Fyntyrosine kinase has a crucial molecular function in building brain network and isolated a novel cadherin-related neuronal receptor (CNR) family proteins localized on the cell membrane of the cortical neurons using Fyn binding activity from the mouse brain. Collaborating with Yagi group, we identified a CNR family as a candidate of Reelin receptors. In addition to CNRs, two membrane proteins, apoER2 and VLDLR, have been identified as Reelan receptors. We provided antibodies against these receptor proteins and showed that extracellular Reelin proteins and these receptor proteins are co-localized on the processes of cortical plate neurons. We are now investigating how these receptors act in concert as components of the Reelin receptors. Less

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (67 results)

All Other

All Publications (67 results)

  • [Publications] Drakew,A.,Frotscher,M.,Deller,T.,Ogawa,M.and Heimrich,B.: "Developmental distribution of a reeler gene-related antigen in the rat hippocampal formation visualized by CR-50 immunocytochemistry."Neuroscience. 82. 1076-1086 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sato,Y.,Hirata,T.,Ogawa,M.and Fujisawa,H: "Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract."J.Neurosci.. 18. 7800-7810 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Rice,D.S.,Sheldon,M.,D'Arcangelo,G.Nakajima,K.,Goldowitz,D.andCurran,T: "Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain."Development. 125. 3719-3929 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Senzaki,K.,Ogawa,M.and Yagi,T: "Proteins of the CNR family are multiple receptors for Reelin."Cell. 99. 635-647 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mikoshiba,K.,Aruga,J.,Nagai,T.,Nakata,K.,Nakajima,K.,Miyata,T.and Ogawa,M.: "Molecular mechanism involved in neural induction and neuronal fate determination."Proceeding of the International Workshop 1999,Neuronal Precursor Cell Biology and Application for Treatment of Inborn Error of Metabolism,. 168-183 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Borrell,V.,Del Rio,J.A.,Alcantara,S.,Deren,M.,Martinez,A.,D'Arcangelo,G.Nakajima,K.,Mikoshiba,K.,Derer,P.,Curran,T.and Soriano,E.: "Reelin regulates the development and synaptogenesis of the layer-specific entorhinal-hippocampal connections."J.Neurosci.. 19. 1345-1358 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Utunomlya-Tate,N.,Kubo,K.,Tate,S.,Kainosho,M.,Katayama,E.,Nakajima,K.and Mikoshiba,K.: "Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody."Proc.Natl.Acad.Sci.U.S.A.. 97. 9729-9734 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Darmanto,W.,Inouye,M.,Takagishi,Y.,Ogawa,M.,Mikoshiba,K.and Murata,Y.: "Derangement of Purkinje cells in the rat cerebellum following prenatal exposure to X-irradiation : decreased Reelin level is a possible cause."J.Neuropathol.Exp.Neurol.. 59. 251-262 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawaguchi,A.,Miyara,T.,Sawamoto,K.,Takashita,N.,Murayama,A.,Akamatsu,W.,Ogawa,M.,Okabe,M.,Tano,Y.,Goldman,S.A., and Okano,H.: "Nestin-EGFP trangenic mice : visualization of the self-renewal and multipotency of CNS stem cells."Mol.Cell.Neurosci.. 17. 259-273 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohshima,T.,Ogawa,M.,Veeranna,Hirasawa,M.,Longenecker,G.,Jshiguro,K.,Pant,H.C.,Brady,R.O.,Kulkarni,A.B.and Mikoshiba,K.: "Synergistic contributions of Cdk5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain."Proc.Natl.Acad.Sci.U.S.A.. 98. 2764-2769 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada,M.,Miyakawa,T.,Duttaroy,A.,Moriguchi,T.,Maklta,R.,Ogawa,M.,Chou,C.J.,Xia,B.,Crawtey,J.N.,Felder,C.C.,Deng,C.-X., and Wess,J.: "Mice lacking the M3muscarinic acetylcholine receptor are hypophagic and lean."Nature. 410. 207-212 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 先崎浩次,小川正晴,八木健: "マウス大脳皮質層構造形成機構における新たな分子メカニズムの解明-CNR ファミリーはReelinの多重受容体である-。"実験医学. 18. 784-787 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Alvarez-Dolado,M.,Ruiz,M.,Del Rio.J.A.,Alcantara,S.,Burgaya,F.,Sheldon,M.,Nakajima,K.,Bernal,J.,Howell,B.W.,Soriano,E.and Murioz,A,: "Thyroid hormone regulates reelin and dab1 expression during brain development."J.Neurosci.. 19. 6979-6993 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishikawa,S.,Goto,S.,Hamasaki,T.,Ogawa,M.& Ushio,Y.: "Transient and compartmental expression of the reeler gene product Reelin in the developing rat striatum."Brain Res.. 850. 244-248 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fatemi,S.,Emamian,E.S.,Kist,D.,Sidwell.R.W.,Nakajima,K.,Akhter,P.,Sheikh,S.and Bailey,K.: "Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice."Mol.Pscyiatry. 4. 145-154 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yip,J.W.,Yip,Y.P.L.,Nakajima,K.and Capriotti,C: "Reelin controls position of autonomic neurons in the spinal cord."Proc.Natl.Acad.Sci.U.S.A.. 97. 8612-8616 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kojima,T.,Nakajima,K.and Mikoshiba,K.: "The disabled 1 gene is disrupted by a replacement with L1 fragment in yotari mice"Mol.Brain Res.. 75. 121-127 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamura,Y.,Sakakibara,S.,Mlyata,T.,Ogawa,M.,Shimazaki,T.,Weiss,S.,Kageyama,R.and Okano,H.: "The bHLH gene Hes1 as a repressor of the neuronal commitment of CNS stem cells."J.Neurosci.. 20. 283-293 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 仲嶋一範,御子柴克彦,小川正晴: "大脳・小脳皮質における細胞配列の分子機構。"蛋白質・核酸・酵素. 45. 241-247 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 山田真久,牧田亨介,宮田卓樹,小川正晴: "皮質形成のメカニズム-脳構築を担う液性因子リーリンタンパク質"実験医学. 18. 1276-1282 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 宮田卓樹,小川正晴: "小脳の発生に関する分子機構:プルキンエ細胞と顆粒神経細胞の大河ドラマ"神経研究の進歩. 44. 965-973 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小川正晴: "大脳皮質の構築とリーリンシグナル伝達系"日本神経精神薬理学雑誌(Jpn.J.Neuropsychopharmacol.). 20. 169-174 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 仲嶋一範 ら: "脳神経科学イラストレイテッド(森寿,真鍋俊也,渡辺雅彦,岡野栄之,宮川剛 編)"羊土社. 8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Alvarez-Dolado, M., Ruiz, M., Del Rio, J.A., Alcantara, S., Burgaya, F., Sheldon, M., Nakajima, K., Bernal, J., Howell, B.W., Soriano, E.and Murioz, A.: "Thyroid hormone regulates reelin and dab1 expression during brain development."J.Neurosci.. 19. 6979-6993 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nishikawa, S., Goto, S., Hamasaki, T., Ogawa, M.& Ushio, Y.: "Transient and compartmental expression of the reeler gene product Reelin in the developing rat striatum."Brain Res.. 850. 244-248 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fatemi, S., Emamian, E.S., Kist, D., Sidwell, R.W., Nakajima, K., Akhter, P., Sheikh, S.and Bailey, K.: "Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice."Mol.Pscyiatry. 4. 145-154 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yip, J.W., Yip, Y.P.L., Nakajima, K.and Capriotti, C.: "Reelin controls position of autonomic neurons in the spinal cord."Proc.Natl.Acad.Sci.U.S.A.. 97. 8612-8616 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kojima, T., Nakajima, K.and Mikoshiba, K.: "The disabled 1 gene is disrupted by a replacement with L1 fragment in yotari mice."Mol.Brain Res.. 75. 121-127 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakamura, Y., Sakakibara, S., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R.and Okano, H.: "The bHLH gene Hes1 as a repressor of the neuronal commitment of CNS stem cells."J.Neurosci. 20. 283-293 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Drakew, A., Frotscher, M., Deller, T., Ogawa, M.and Heimrich, B.: "Developmental distribution of a reeler gene-related antigen in the rat hippocampal formation visualized by CR-50 immunocytochemistry."Neuroscience. 82. 1076-1086 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sato, Y., Hirata, T., Ogawa, M.and Fujisawa, H.: "Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract."J.Neurosci.. 18. 7800-7810 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Rice, D.S., Sheldon, M., D'Arcangelo, G.Nakajima, K., Goldowitz, D.and Curran, T.: "Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain."Development. 125. 3719-3929 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Senzaki, K., Ogawa, M.and Yagi, T.: "Proteins of the CNR family are multiple receptors for Reelin."Cell. 99. 635-647 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mikoshiba, K., Aruga, J., Nagai, T., Nakata, K., Nakajima, K., Miyata, T.and Ogawa, M.: "Molecular mechanism involved in neural induction and neuronal fate determination."Neuronal Precursor Cell Biology and Application for Treatment of Inborn Error of Metabolism. 168-183 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Borrell, V., Del Rio, J.A., Alcantara, S., Deren, M., Martinez, A., D'Arcangelo, G.Nakajima, K., Mikoshiba, K., Derer, P., Curran, T.and Soriano, E.: "Reelin regulates the development and synaptogenesis of the layer-specific entorhinal-hippocampal connections."J.Neurosci.. 19. 1345-1358 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Utunomiya-Tate, N., Kubo, K., Tate, S., Kainosho, M., Katayama, E., Nakajima, K.and Mikoshiba, K.: "Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody."Proc.Natl.Acad.Sci.U.S.A.. 97. 9729-9734 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Darmanto, W., Inouye, M., Takagishi, Y., Ogawa, M., Mikoshiba, K.and Murata, Y.: "Derangement of Purkinje cells in the rat cerebellum following prenatal exposure to X-irradiation : decreased Reelin level is a possible cause."J.Neuropathol.Exp.Neurol.. 59. 251-262 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawaguchi, A., Miyata, T., Sawamoto, K., Takashita, N., Murayama, A., Akamatsu, W., Ogawa, M., Okabe, M., Tano, Y., Goldman, S.A., and Okano, H.: "Nestin-EGFP trangenic mice : visualization of the self-renewal and multipotency of CNS stem cells."Mol.Cell.Neurosci.. 17. 259-273 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohshima, T., Ogawa, M., Veeranna, Hirasawa, M., Longenecker, G., Jshiguro, K., Pant, H.C., Brady, R.O., Kulkarni, A.B.and Mikoshiba, K.: "Synergistic contributions of Cdk5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain."Proc.Natl.Acad.Sci.U.S.A.. 98. 2764-2769 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamada, M., Miyakawa, T., Duttaroy, A., Moriguchi, T., Makita, R., Ogawa, M., Chou, C.J., Xia, B., Crawley, J.N., Felder, C.C., Deng, C.X., and Wess, J.: "Mice lacking the M3muscarinic acetylcholine receptor are hypophagic and lean."Nature. 410. 207-212 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Darmanto,W. et al.: "Derangement of Purkinje cells in the rat cerebellum following prenat al exposure to X-irradiation : decreased Reelin level is a possible"J.Neuropathol.Exp.Neurol.. 59. 251-262 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawaguchi,A. et al.: "Nest in-EGFP trangenic mice : visualization of the self-renewal and mult ipotency of CNS stem cells"Mol.Cell.Neurosci.. (In press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohshima,T. et al.: "Synergistic contributions of Cdk5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain."Proc.Natl.Acad.Sci.U.S.A.. (In press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamada,M. et al.: "Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean."Nature. (In press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Kojima,T. et al.: "The disabled 1 gene is disrupted by a replacement with L1 fragment in yotari mice"Mol.Brain Res.. 75. 121-127 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yip,J.W. et al.: "Reelin controls position of autonomic neurons in the spinal cord"Proc.Natl.Acad.Sci.U.S.A.. 97. 8612-8616 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Utsunomiya-Tate,N., et al: "Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody"Proc.Natl.Acad.Sci.U.S.A. 97. 9729-9734 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tabata,H. et al: "Efficient in utero gene transfer system to the developing mouse brains using electroporation-Visualization of neuronal migration in the developing cortex"Neuroscience. (In press).

    • Related Report
      2000 Annual Research Report
  • [Publications] 先崎浩次 ら: "マウス大脳皮質層構造形成機構における新たな分子メカニズムの解明-CNRファミリーはReelinの多重受容体である-"実験医学. 18. 784-787 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 仲嶋一範 ら: "大脳・小脳皮質における細胞配列の分子機構"蛋白質・核酸・酵素. 45. 241-247 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 山田真久 ら: "皮質形成のメカニズム-脳構築を担う液性因子リーリンタンパク質"実験医学. 18. 1276-1282 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 宮田卓樹 ら: "小脳の発生に関する分子機構:プルキンエ細胞と顆粒神経細胞の大河ドラマ"神経研究の進歩. 44. 965-973 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 仲嶋一範 ら: "脳神経科学イラストレイテッド(森寿,真鍋俊也,渡辺雅彦,岡野栄之,宮川剛編)"羊土社. 8 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Hossein Fatemi: "Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice"Molecular Psychiatry. 4. 145-154 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Manuel Alvarez-Dolado: "Thyroid hormone regulates reelin and dabl expression during brain development"J.Neurosci.. 19. 6979-6993 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toshio Kojima: "The disabled 1 gene is disrupted by a replacement with L1 fragment in yotari mice"Mol.Brain Res.. 75. 121-127 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Katsuhiko Mikoshiba: "Molecular mechanism involved in neural induction and neuronal fate determination"Neuronal Precursor Cell Biology and Application for Treatment of Inborn Error of Metabolism. 168-183 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kazunori Nakajima: "Defining how the dramatype is developed in mouse model in view of clinical benefit for human"Microbial and Phenotypic Definition of Rats and Mice. (印刷中).

    • Related Report
      1999 Annual Research Report
  • [Publications] 仲嶋一範: "disabled"細胞内シグナル伝達改訂第2版(BioScience用語ライブラリー). 166-167 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 仲嶋一範: "大脳・小脳皮質における細胞配列の分子機構"神経回路形成と機能発達(蛋白質 核酸 酵素 増刊号). 45. 241-247 (2000)

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      1999 Annual Research Report
  • [Publications] Shigeyuki Nishikawa: "Transient and compartmental expression of the reeler gene product Reelin in the developing rat striatum"Brain Res.. 850. 244-248 (1999)

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      1999 Annual Research Report
  • [Publications] Kouji Senzaki: "Proteins of the CNR Family Are Multiple Receptors for Reelin"Cell. 99. 635-647 (1999)

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      1999 Annual Research Report
  • [Publications] Yuki Nakamura: "The bHLH Gene Hes1 as a Repressor of the Neuronal Commitment of CNS Stem Cells"J.Neurosci.. 20. 283-293 (2000)

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      1999 Annual Research Report
  • [Publications] Drakew A.et al.: "Developmental distribution of a reeler gene-related antigen in the rat hippocampal formation visualized by CR-50 immunocytochemistry." Neurosci.82. 1076-1086 (1998)

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      1998 Annual Research Report
  • [Publications] Sato Y.et al.: "Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract." J.Neurosci.18. 7800-7810 (1998)

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      1998 Annual Research Report
  • [Publications] Rice D.S.et al.: "Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain." Development. 125. 3719-3729 (1998)

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      1998 Annual Research Report
  • [Publications] Borrell V.et al.: "Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections." J.Neurosci.19. 1345-1358 (1999)

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      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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