|Budget Amount *help
¥2,800,000 (Direct Cost : ¥2,800,000)
Fiscal Year 1999 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1998 : ¥2,300,000 (Direct Cost : ¥2,300,000)
A New Route for Preparation of Pyranose-type Phospha-sugars.
D-gluco and L-idopyranose phospha-sugars were prepared in 6 steps, by starting with 3, 6-di-O-benzyl-1, 2-O-isopropylidene-α-D-xylo-hexofuranos-5-ulose.
2. Synthesis of D-Galactopyranose Phospha-sugar.
D-galactopyranose phospha-sugar was prepared in 6 steps, by starting with 3, 6-di-O-benzyl-1, 2-O-isopropylidene-β-L-arabino-hexofuranos-5-ulose.
3. Synthesis of D-mannosamine Phospha-sugar.
3, 6-Di-O-benzyl-5-O-deoxy-5-dimethylphosphinyl-1,2 O-isopropylidene-α-D-glucofuranose was converted, in 4 steps, into methyl 2-acetamido-3, 6-di-O-benzyl-2, 5-dimethoxyphosphinyl-α-D-mannofuranoside, which led to 3, 5-di-O-benzyl derivatives of D-mannosamine phospha-sugar.
4. The effect of a Phosphorus Atom upon Vicinal ィイD11ィエD1H-ィイD11ィエD1H Coupling Constants in Phospha-sugars.
Additivity constants for phosphorus were estimated for the prediction of vicinal ィイD11ィエD1H-ィイD11ィエD1H coupling constants by means of an additivity rule in a series of pyranose-type phospha-sugars.