DEVELOPMENT OF ORGANIC/INORGANIC BIOACTIVE COMPOSITE MATERIALS WITH BIOCOMPATIBILITY AND FLEXIBILITY
| Project/Area Number |
10650681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Composite materials/Physical properties
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| Research Institution | KINKI UNIVERSITY |
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Principal Investigator |
HONTSU Shigeki KINKI UNIVERSITY, 生物理工学部, 教授 (40157102)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | HYDROXYAPATITE / PULSED LASER DEPOSITION / BIOCERAMICS / IMPLANT / IN-VITRO / BIOCOMPATIBLE |
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| Research Abstract |
The organic/inorganic bioactive composite materials should become important and useful in the medical field. The present study concerns the fabrication of crystallized hydroxyapatite [CaィイD210ィエD2(POィイD24ィエD2)ィイD26ィエD2(OH)ィイD22ィエD2 : HAp] films on polymer material substrates such as polyamides(PI), polytetrafluoroethylene(PTFE) and aramid(AM) using the ArF excimer laser deposition technique. The crystallized HAp films were fabricated using an after annealing method and were obtained on PI, PTFE and AM. The mechanical properties of HAp films on the polymer materials were examined using a peeling-off test. The tensile bond strength of HAp film on PI and PTFE were 9.8MPa and 0.4MPa, respectively. The adhesion force between a HAp film and PTFE is very small, because PTFE is chemically stable and has an extremely low friction coefficient. An increase in the HAp/PTFE adhesion force was desirable for the surface treatment of PTFE. The surface of PTFE was modified by a sodium-naphthalene complex in a glycol ether solvent for enhanced adhesion. The tensile bond strength of HAp films on surface-modified PTFE was 6.0Mpa, which was one order of magnitude larger than that of films on non-surface-modified PTFE. The biocompatibility of HAp films on surface-modified PTFE was also studied by in-vitro experiments. In this experiment, fibroblasts cells were used for osteoblastic cells attached and proliferated on the PTFE substrate. This result indicates that the HAp films with laser ablation were useful for the biocompatible coating material of implant.
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Report
(3 results)
Research Products
(13 results)
