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Study on the bladder cancer susceptibility gene and the inhibitory factor of bladder cancer in rats

Research Project

Project/Area Number 10670208
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionThe University of Tokushima

Principal Investigator

IZUMI Keisuke  2nd Dept. of Pathology, School of Medicine, University of Tokushima, Professor, 医学部, 教授 (30116777)

Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1999: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1998: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsLEC rat / bladder carcinogenesis / susceptibility gene / linkage analysis / copper / 低感受性
Research Abstract

1) We found that the LEC rat is resistant to N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced urinary bladder carcinogenesis. When male LEC and F344 rats were given 0.1% BBN in their drinking water for 7 days, the intake of BBN and urinary concentration of its active metabolite, N-butyl-N-(3-carboxypropyl)nitrosamine, were higher in the LEC rats (P<0.01). The urinary pHS of untreated LEC and F344 rats were similar between week 6 and 30. The urinary copper concentration was lower in LEC rats before jaundice than in F344 rats, but its concentrations in 28- and 50-week-old LEC rats were 1.7 and 2.3 times those in F344 rats. In a two-stage carcinogenesis study using F344 rats, i.p. injections of cupric nitrilotriacetate increased urinary copper excretion, and inhibited BBN-induced bladder carcinogenesis. In a two-stage carcinogenesis study using LEC rats, oral administration of D-penicillamine decreased urinary copper excretion, and increased BBN-induced bladder cancer, although the difference was not significant. These data suggest that urinary copper has an inhibitory effect on bladder carcinogenesis.
2) We tried to identify possible quantitative trait loci responsible for low susceptibility to BBN-induced bladder carcinogenesis in LEC rats using (F344 x LEC)F2 rats, but we could not find any loci yet. There is no clear evidence that Atp7b gene is related to its low susceptibility.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Wei,S.et al.: "An integrated genetic map of the rat with 562 mrarkers from different sources"Mamm.Genome. 9. 1002-1007 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kitaura,K.et al.: "Role of copper accumulation in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats"Jpn.J.Cancer Res.. 90. 385-392 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jiao,Z.et al.: "Effects of D-galactosamine hydrochloride and partial hepatectomy on wpontaneous hepatic injury and hepatocarcinogenesis in Long-Evans Cinnamon rats"Jpn.J.Cancer Res.. 90. 496-504 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wei,S.et al.: "Identification of a locus for susceptibility to renal cell carcinoma in the Long-Evans Cinnamon rats"J.Vet.Med.Sci.. 61. 1261-1264 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chone,Y.et al.: "Low susceptibility of Long-Evans Cinnamon rats to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis and inhibitory effect of urinary copper"Jpn.J.Cancer Res.. 91. 16-24 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wei, S., et al.: "An integrated genetic map of the rat with 562 markers from different sources."Mamm. Genome. 9. 1002-1007 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kitaura, K., et al.: "Role of copper accumulation in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats."Jpn. J. Cancer Res.. 90. 385-392 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Jiao, Z., et al.: "Effects of D-galactosamine hydrochloride and partial hepatectomy on spontaneous hepatic injury and hepatocarcinogenesis in Long-Evans Cinnamon rats."Jpn. J. Cancer Res.. 90. 496-504 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wei, K., et al.: "Identification of a locus for susceptibility to renal cell carcinoma in the Long-Evans Cinnamon rat."J. Vet. Med. Sci.. 61. 1261-1264 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chone, Y., et al.: "Low susceptibility of Long-Evans Cinnamon rats to N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis and inhibitory effect of urinary copper."Jpn. J. Cancer Res.. 91. 16-24 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wei,S.et al.: "An integrated genetic map of the rat with 562 markers from different sources"Mamm.Genome. 9. 1002-1007 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kitaura,K.et al.: "Role of copper accumulaton in spontaneous renal carcinogenesis in Long-Evans Cinnamon rats."Jpn.J.Cancer Res.. 90. 385-392 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Jiao,Z.et al.: "Effects of D-galactosamine hydrochloride and partial hepatectomy on spontaneous hepatic injury and hepato-carcinogenesis in LONG-Evans Cinnamon rats"Jpn.J.Cancer Res.. 90. 496-504 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Wei,K.et al.: "Identification of a locus for susceptibility to renal cell carcinoma in the Long-Evans Cinnamon rat"J.Vet.Med.Sci.. 61. 1261-1264 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chone,Y.et al.: "Low susceptibility of Long-Evans Cinnamon rats to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced uriary bladder carciongenesis and inhibitory effect of urinary copper"Jpn.J.Cancer Res.. 91. 16-24 (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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