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The effects of exercises and stresses on the growth of malignant cells and non-specific immune activity

Research Project

Project/Area Number 10670327
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionWaseda University

Principal Investigator

MACHIDA Kazuhiko  Waseda University, School of Human Sciences, Professor, 人間科学部, 教授 (00111104)

Co-Investigator(Kenkyū-buntansha) OHTA Hukio  Waseda university School of Human Sciences, Professor, 人間科学部, 教授 (20092041)
HAYASI Osamu  Kagawa Nutrition Univ.Dept.of Health and Nutrition, Professor, 栄養学部, 教授 (20133340)
稲 恭宏  早稲田大学, 人間科学部, 助手 (80308220)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsimmune / cancer / rat / stress / exercise / selenium / spirulina / flow cytometry / スピルリオ / 非特異免疫 / 臨床検査 / SST-2細胞 / 腫瘍細胞 / 生体防御機能 / 自由運動 / 活性酸素 / 強制運動 / 特異免疫 / 生化学検査 / SST2細胞
Research Abstract

We have been tried to clarify the relation between life style and biophylaxis function by many animal experiments, the survey through health administration in elderly people yet. As these results, lesser stress and adequate free running play big role to the improvement of the their biophylaxis which was gained by non-specific immune activity. We tried following three animal experiments to evaluate the influence on the cancer of their life style (stress, physical fitness and nutrition) by the measure of the tumor's weight and some tests for the biophylaxis. We used physical stress (electric stimulation) and psychological stress as stress load methods, voluntary exercise by running wheel and compulsory exercise by tread mill as exercise methods, and selenium and spirulina as the supplements of anti-oxidants.
The weight of malignant cells administered from the back skin of rats loaded stresses by two methods increased significantly in comparison with control rats. But surprisingly. those of rats which was given stresses up to the administration of malignant cells and was stopped stress load after it decreased significantly. These results was in accord with the results of neutrophilis function, NK actitivity and mitogenic response of lymphocytes. The weight of malignant cells in voluntary exercise group decreased and NK activity increased significantly in comparison with control group, but those of tread mill group did not change. The weight of malignant cells Se group and Spirulina group decreased both in comparison with control group. Though their biophylaxis function were not recognized big change such as the stress and the exercise experiments, Spirulina with malignant cells group suggested the possibility of the induction of some subsets of lymphocytes

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 西卷尚美,町田和彦 他: "ラットの皮下移植腫瘍がナチュラルキラ細胞活性に及ぼす影響"体力・栄養・免疫学雑誌. 8. 153-154 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 西卷尚美,町田和彦 他: "腫瘍細胞接種ラットに及ぼす運動の影響"体力・栄養・免疫学雑誌. 10. 118-119 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] "Effects of administered malignant cells on natural killer activity in rats"J Pys.fitt..nutr.immun.. 8 (2). 153-154 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] "Effects of exercise on NK activity of rats with administered malignant cells"J Pys.fitt..nutr.immun.. 10 (2). 118-119 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 山崎享子,町田和彦 他: "Flow Cyto metry法を用いた好中球の貪食・殺菌能の測定と評価"日本衛生学雑誌. 56・1. 356 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 佐藤理恵,町田和彦 他: "腫瘍細胞摂取ラットに及ぼす機能性食品の影響第3報ミネラル〓"日本衛生学雑誌. 56・1. 379 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 信田直己,町田和彦 他: "腫瘍細胞摂取ラットに及ぼす機能性食品の影響第2報非特異的生体防御機能"日本衛生学雑誌. 56・1. 378 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 藤岡洋成,町田和彦 他: "腫瘍細胞摂取ラットに及ぼす機能性食品の影響第1報リンパ球を中心とした白血球機能"日本衛生学雑誌. 56・1. 377 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 藤岡洋成,町田和彦 他: "腫瘍細胞接種ラットに及ぼす運動の影響(1)血液細胞"日本衛生学雑誌. 55・1. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 緑川泰史,町田和彦 他: "腫瘍細胞接種ラットに及ぼす運動の影響(2)非特異的生体防御特性"日本衛生学雑誌. 55・1. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 町田和彦(第一著者 西尾尚美): "ラットの皮下移植腫瘍がナチュラルキラー細胞活性に及ぼす影響" 体力・栄養免疫学雑誌. 8・2. 153-154 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 町田和彦(第一著者 西尾尚美): "腫瘍細胞接種ラットに及ぼす影響(2)非特異的生体防御機能" 日本衛生学雑誌. 54・1. 384 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 町田和彦(第一著者 藤岡洋成): "腫瘍細胞接種ラットに及ぼす影響(1)生体諸機能" 日本衛生学雑誌. 54・1. 383 (1999)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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