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THE BLUNTED VENTILATORY RESPONSE IN PATIENTS WITH AUTONOMIC NEUROPATHY

Research Project

Project/Area Number 10670554
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKUMANOTO UNIVERSITY

Principal Investigator

KAWANO Osamu  KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE, FIRST DEPARTMENT OF INTERNAL MEDICINE, ASSISTANT PROFESSOR, 医学部, 助手 (40253728)

Co-Investigator(Kenkyū-buntansha) KOHROGI Hirotugu  KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE, FIRST DEPARTMENT OF INTERNAL MEDICINE, LECTURER, 医学部・附属病院, 講師 (00178237)
MASAYUKI Ando  KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE, FIRST DEPARTMENT OF INTERNAL MEDICINE, PROFESSOR, 医学部, 教授 (00040204)
岡部 紘明  熊本大学, 医学部, 教授 (20185466)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
KeywordsVENTILATOEY RESPONSE / AUTONOMIC NEUROPATHY / BRATHLESSNESS / 自律神経異常 / 瞳眠
Research Abstract

Although autonomic dysfunction (AD) has been described in many medical disorders, there are little recognized clinica sequelae of AD involving respiratory system. To investigate the effect of systemic peripheral AD on ventilatory response in human, we measured the responsiveness to hyperoxic progressive hypercapnia in 12 healthy subjects and 8 patients with familial amyloidotic polyneuropathy and AD (type I FAP). Spirometry were performed in all subjects and arterial blood gas analysis was done in each patient breathing room air at rest. The hypercapnic responsiveness, measured by using a system in which end-tidal PCO2 (PETCO2) and PO2 (PETO2) were automatically regulated, were assessed in terms of the slope of ventilation as a function of the PETCO2. The resting pH and PaO2 of the patients were almost in normal range, but PaCO2 in five were elevated over 44 mmHg, and this was limited in patients with advanced AD.Furthermore the mean base line minute ventilation (VE) of patients was si … More gnificantly lower than that of normal subjects (p<0.01), however the difference of mean respiratory frequency was not significant (p>0.7). There was significant correlation between resting PaCO2 and the severity of of AD (p <0.01) and significant negative correlation between base line VE and AD (p<0.03) in patients with FAP.The magnitudes of responsiveness to CO2 of these patients were significantly lower than those of normal subjects (p<0.05). These findings suggest systemic peripheral autonomic functions may play a role in regulating ventilation during hypercapnia. We concluded FAP with peripheral AD should be listed as a cause of hypoventilation.
Although autonomic dysfunction (AD) has been described in many medical disorders, there are little recognized clinica (sequelae of AD involving respiratory system. To investigate the effect of systemic peripheral AD on ventilatory response in human, we measured the responsiveness to hyperoxic progressive hypercapnia in 12 healthy subjects and 8 patients with familial amyloidotic polyneuropathy and AD (type l FAP). Spirometry were performed in all subjects and arterial blood gas analysis was done in each patient breathing roomair at rest. The hypercapnic responsiveness, measured by using a system in which end-tidal PCO2 (PETCO2) and PO2 (PETO2) were automatically regulated, were assessed n terms of the slope of ventilation as a function of the PETCO2. The resting pH and PaO2 of the patients were almost in normal range, but PaCO2 in five were elevated over 44 mmHg, and this was limited in patients with advanced AD.Furthermore the mean base line minute ventilation (VE) of patients was significantly lower than that of normal subjects (p<0.01), however the difference of mean respiratory frequency was not significant (p>0.7). There was significant correlation between resting PaC02 and the severity of of AD (p <0.01) and sinificant negative correlation between base line VE and AD (p<0.03) in patients with FAP.The magnitudes of responsiveness to CO2 of these patients were significantly lower than those of normal subjects (p<0.05). These findings suggest systemic perjpheraj autonomic functions may play a role in regualting ventilation during hypercapnia. We concluded FAP with peripheral AD should be listed as a cause of hypoventilation. Less

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] H.Kohrogi,O.Kawano M.Ando: "The role of cysteinyl leukotrienes in the pathogenesis of asthma:Clsnical study of leuko triepe antagonist prank kast"Respirology. 4・3. 319-323 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] E Goto,H Kohrogi O.Kawano,M Ando: "Human Bronchial LnDra-epithelial T Lymphotes as a Distiuct Tcell Subset:Their Long-Term Suruival in SCID-Hu Chimeres"American Journal of Respiratory Cell and Molecular Biology. 22. 405-411 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 後藤英介,興ろぎ博次,河野 修,安藤正幸: "SCIDマウスに移植したHuman Bronclrial Xenograftにおける肥満細胞についての検討"呼吸. 18. 41-42 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 津守香里,興ろぎ博次,河野 修,安藤正幸: "Derf特異的T細胞株におけるホーミングレセプター発現とサイトカインの関与"呼吸. 18. 70-71 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 後藤英介,興ろぎ博次,河野 修,安藤正幸: "T細胞の気道組織接着における各種接着分子発現の役割について"呼吸. 19(2). 57-58 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] O.Kawano,H.Kohrogi: "The role cysteinyl leukotrienes in the pathogenesis of asthma:clinical study of leukotriene antagonist pranlukast"Respirology. 4・3. 319-323 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H.Kohrogi,E.G.to O.Kawano: "Human Bronchial Intra-Epithelial T Lymphocytes as a Distinct T Cell Subset:Their Long-Term Survival in SCID-Hu Chimeras."American Journal of Rrespiratory Cell and Molecular Biology. (in press). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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