| Project/Area Number |
10670769
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
TERADA Kihei Medicine, Kawasaki Medical School, Assistant Professor, 医学部, 講師 (50172094)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | secretory IgA antibody / varicella vaccine / chickenpox / 不活化水痘ワクチン / 鼻腔内噴霧 |
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| Research Abstract |
Breakthrough after varicella vaccination occurs in approximately 2.6%- 18.6% of immunocompetent children, but the reason has not clearly been demonstrated. As a first defense, specific secretory IgA antibody on the mucosa plays an important role in preventing invasion of microorganisms. To analyze induction of varicella-zoster virus (VZV) specific secretory IgA after natural infection and vaccination and its booster mechanisms, we examined 143 salivary samples using ELISA. The VZV-secretory IgA values were significantly higher in the matched children after natural chickenpox than in those after vaccination, although the total secretory IgA did not differ between them. Two (7%) of the vaccinees lacked the sIgA antibody. In the elderly and in immunocompromised children, the VZV-secretory IgA values were no lower than those in healthy children, and they did not lack VZV-secretory IgA. The doctors and nurses taking care of patients with chickenpox had higher values than the other groups as did individuals who had had herpes zoster recently. VZV-secretory IgA was thought to be stimulated by exogenous and reactivated endogenous VZV to neutralize VZV with weak activity. These results suggest that low or no induction of VZV-secretory IgA antibody after vaccination may be one of the possible explanations for breakthrough after it.
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