| Project/Area Number |
10671021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KURODA Yasuhiro University of Tokushima, School of Medicine, Professor, 医学部, 教授 (20035471)
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| Co-Investigator(Kenkyū-buntansha) |
HAYABUCHI Yasunobu University of Tokushima, School of Medicine, medical staff, 医学部・附属病院, 医員(臨床)
MORI Kazuhiro University of Tokushima, School of Medicine, Lecturer, 医学部・附属病院, 講師 (70220001)
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| Project Period (FY) |
1998 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | long QT syndrome / fetal electrocardiography / signal-averaged electrocardiography |
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| Research Abstract |
We developed the method for non-invasive recording of fetal electrocardiogram using singal-averaged electrocardiography. At first, we determined the optimal setting for signal-averaged electrocardiography. Fetal electrocardiography shows tachycardia with high frequency. We established the system which separated fetal electrocardiography from mother's low frequent component with signal noise. The noise was decreased by using analog-filter, and true electrocardiographic components were amplified. After changing these data to digital-signal, maternal electrocardiography was subtracted, and only fetal electrocardiography kept remained. The several resources was administered in order to get more purified fetal electrocardiography. To decrease maternal noise, Ag/AgCl electrodes were used with keretin-cream on her abdominal skin. As a low pass filter of 2Hz was suitable for reducing artifact due to movement and respiration of fetus. Time duration for subtraction of maternal electrocardiography was set at the peak of her QRS wave ±400 msec. Recently, more sensitive filter with 0.3 mV was used.
In clinical setting, electrocardiogram of fetal arrhyihmia (ventricular premature beat) and long QT syndrome could be recorded. Especially in long QT syndrome, this method is quite useful for its diagnosis and management after birth.
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