|Budget Amount *help
¥1,200,000 (Direct Cost : ¥1,200,000)
Fiscal Year 2000 : ¥600,000 (Direct Cost : ¥600,000)
Fiscal Year 1999 : ¥600,000 (Direct Cost : ¥600,000)
Aim : Crohn's disease is the intractable inflammatory bowel disease which often needs surgical treatment for fibrotic intestinal stricture or fistula. High postoperative recurrence is well known and surgical indication, which is perforating type and non perforating type, was reported as one of the risk factors. Collagen type in the intestinal stricture of Crohn's disease was reported to be different from that of normal intestine. The aim of study was to analyze collagen type in the different type of lesion in the resected specimen of Crohn's disease and to examine correlation between collagen type in different morphological lesion and postoperative recurrence.
Patients and method : Type of collagen (I, III, V) was analyzed in resected specimen of Crohn's disease (stricture : 10, ulcer : 20, fistula : 21, thick bowel wall : 11, edema : 3, macroscopically normal intestine : 48 ) and 12 normal control intestine with colorectal cancer patients.
Results : 1) Type I, III collagen content : The
re were no difference between control and whole Crohn's disease group, control and each Crohn's disease group. No difference was also found in type I, III collagen contents among each Crohn's disease group.
Type V collagen content : Type V collagen content was 10% in control, 8.5% in macroscopically normal intestine of Crohn's disease, 7.1% in stricture, 8.3% in ulcer, 7.97% in fistula, 6.9% in thick bowel wall, 7.9% in edematous intestine. Type V collagen content was lower in whole Crohn's disease group, in each Crohn's disease group than control with statistically significance. However, content in fistula site and non fistula site (stricture, ulcer, thick bowel wall, edematous intestine) was 7.97%, 7.66% respectively, without statistical difference.
Conclusion : Intestinal collagen content in Crohn's disease was different from that of normal bowel in terms of low type V collagen content. Collagen content of Crohn's disease intestine had no influence on postoperative recurrence because of no difference between perforating and non perforating lesion, which is thought to be one of the risk factor for postoperative recurrence. Less