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The Molecular Mechanism of Late Phase Adverse Reaction of Contrast Media

Research Project

Project/Area Number 10671772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionKagoshima University

Principal Investigator

NOIKURA Takenori  Kagoshima University, Faculty of Dentistry, Professor, 歯学部, 教授 (40102561)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Ikuro  Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (20082282)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsAdverse reaction / Late phase / Endothelial cells / P-selectin / NF-kappa B / nitruc oxide / iNOS / Contrast media / P-selectin、ICAM-1 / NF-κBの活性化 / 誘導型NO合成酵素(iNOS) / NOの生産 / P-selectin,ICAM-1 / 誘導型NO合成酵素(NOS) / NOの産生
Research Abstract

Endothelial Selectins, such as P-selectin and E-selectin, mediate cell adhesion of monocytes or neutrophils to activated endothelial cells. Previously we reported an upregulated expression of inflammatory cytokines by P-selectin-mediated neutrophil attachment to activated endothelium stimulated by contrast media.
We examined the effect of endothelial selectins on the expression of inflammatory cytokines, nitric oxide production and on the activation of NF-kappa B. We found that the soluble forms of P-selectin and E-selectin as well as the monocyte-endothelial interaction induced upregulated the expression of inflammatory cytokines and the production of nitric oxide. These expression of inflammatory cytokines involved the activation of NF-kappa B pathway by the reactive oxygen intermediate (ROI). P-selectin specifically induced β2-integrin (CD11b)-mediated sticky adhesion of monocytes, via ROI generation. Then P-selectin-mediated rapid activation of NF-kappa B, which was augmented by following with β2-integrin (CD11b)-induced sticky adhesion. The binding of endothelial selectins to monocytes in the area of vascular activation by contrast media is considered to be a component of the mechanism that initiates thrombosis and hypotension after the administration of contrast media.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Nakata. M, Maruyama. I: "Leptin Promotes Aggregation og Human Platelets via the Long Form of Its Receptor"DIABETES. 48. 426-429 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakashima M, Maruyama I: "A novel recombinant soluble thrombomodulin, ART-123, activates the protein C pathway in healthy male volunteers"J. Clin. Pharmacol.. 38. 540-544 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsushita Y., Maruyama I: "A subcloned human esophageal squamous cell carcinoma cell line with low thrombomodulin expression showed increased invasiveness compared high thrombomodulin expressing clone-thrombomodulin as a possible candidate for an adhesion molecule ofsquamous cell carcinoma"Cancer Lett. 127. 195-201 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishi J, Maruyama I: "Difference in incidence and transmission mode of methicillin-resistant Staphylococcus aureus among surgery, orthopedics, and pediatrics words: a prospective study at a university hospital"Infect. Control. Hosp. Epidemiol.. 19. 107-109 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakata M., Maruyama, I: "DX9065X, an Xu inhibitor, inhibits prothrombin-induced A549 lung adenocarcinoma cell proliferation"Cancer Lett. 122. 127-133 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maruyama I: "Recombinant thrombomodulin and activated protein C in the treatment of dissem intravascular"Thromb Haemost. 82. 718-721 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakata M, Maruyama I.: DIABETES. 48. 426-429 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakashima M, Maruyama I.: J. Clin. Pharmacol.. 38. 540-544 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsushita Y, Maruyama I: Cancer Lett.. 127. 195-201 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishi J, Maruyama I.: Infect. Control. Hosp. Epidemiol.. 19. 107-109 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakata M, Maruyama I: Cancer Lett.. 122. 127-133 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maruyama I: Thromb Hoemost. 82. 718-721 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakata.m,maruyama.I: "Leptin Promotyes Aggregution of Human Platefets via the Long Form of Its Receptor"DIABETES. 48. 426-429 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakashima.m,maruyama,I: "A novel recombinant soluble thrombomdulin,ART-123,activates the protein C pathwwway inhealthy male volunteers"Jclin.Pharmacol. 38. 540-544 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsushita.Y,Maruyama.I: "A subcloned buman esophageal sqaumous cell carcinoma cell line with low thrombommdulin expression showed increased invasiveness comared with ahigh thcombomodolin-expressing clone-thcombomodulin as possible candidate for an malecufe of sqyamous cell carcin"Cancer Lett. 127. 195-201 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nashi.J,Maruyama.I: "Difference in incidence and trnsmission made of methicillin-resistannt Staphlococcus among suregery,orthopedics,and pedintrics words:a ptospective study at university hospital"Infect.Control.Hosp.Epidemiol. 19. 107-109 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakata.M,Maruyama.I: "DX9065X,an Xa inhibitor,inhibits prothrombin-induced A549 lung adenocarcinom a cell proliferation."Cancer Lett. 122. 127-133 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Maruyama.I: "Recombinant thrombomodulin and activated protein C in the treatment of desseninated intravascular."Thromb Haemost.. 82. 718-721 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakata.M,Maruyama.I,: "Leptin Promotes Aggregation of Human Platelets via the Long Form of Its Receptor" DIABETES. 48. 426-429 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakashima.M,Maruyama.I,: "A novel recombinant soluble thrombomodulin,ART-123,activates the protein C pathway in healthy male volunteers" J.Clin.Pharmacol. 38. 540-544 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsushita.Y,Maruyama.I,: "A subcloned human esophageal sqaumous cell carcinoma cell line with low thrombomodulin expression showed increased invasiveness compared with a high thrombomodulin-expressing clone-thrombomodulin as a possible candidate for an adhesion molecule of squamous cell carcinama" Cancer Lett. 127. 195-201 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishi.J,Maruyama.I,: "Difference in incidence and transmission mode of methicillin-resisatant Staphylococcus aureus among suregery,orthopedics,and prdiatrics words:a prospective study at a university hospital." Infect.Control.Hosp.Epidemiol.19. 107-109 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakata.M,Maruyama.I,: "DX9065X,an Xa inhibitor,inhibits prothrombin-induced A549 lung adenocarcinoma cell proliferation." Cancer Lett. 122. 127-133 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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