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Influence of osteoporosis and aging in the bone structure to biomaterial

Research Project

Project/Area Number 10671831
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionThe University of Tokushima

Principal Investigator

ICHIKAWA Tetsuo  The University of Tokushima, School of Dentistry, Professor, 歯学部, 教授 (90193432)

Co-Investigator(Kenkyū-buntansha) OKA Kenji  The University of Tokushima, Dental Hospital, Instructor, 歯学部・附属病院, 助手 (40253215)
KANITANI Hideo  The University of Tokushima, School of Dentistry, Instructor, 歯学部, 助手 (10294711)
KAWANO Fumiaki  The University of Tokushima, Dental Hospital, Lecturer, 歯学部・附属病院, 講師 (60195120)
SAIKA Miyuki  The University of Tokushima, Dental Hospital, Instructor, 歯学部・附属病院, 助手 (80274231)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsdental implant / bone-implant interface / hydroxyapatite / titanium / osteoporosis / 老齢 / インプラント / インプラント周囲骨 / アパタイト
Research Abstract

The aim of this experimental study was to evaluate the influence of osteoporosis induced after implantation on bone structure around dental implants using ovariectomized rats. Tibiae of 30 to 32-old female Wistar rats were used in this study. Hydroxyapatite (HA) and titanium (Ti) rods were inserted into tibiae of 6 4 rats. Six weeks after implantation, 28 rats were ovariectomized (ovx), 26 rats were sham-operated (sham) and 10 rats were sacrificed (control). Four, 8 and 16 weeks following the operation, the rats were sacrificed. The reaction of the bone tissue surrounding HA and Ti implants was examined histologically. The results can be summarized as follows.
1) The body weight of "ovx" rats markedly increased compared with "sham" rats. Trabecular bone volume percent in distal region of femurs of "ovx" was significantly lower than that of "sham" 4, 8 and 16 weeks following the operation. These findings showed that the this model represents osteoporosis.
2) Mature trabecular bone around HA in "ovx" was resorbed chronologically, but some remained at 16 weeks. In "sham", a large amount of trabecular bone remained around the HA and was connected to the cortical bone as seen m "control" The area of connective tissue increased chronologically m the HA and bone interface. Sixteen weeks following the operation, fibrous tissue was observed on the implant surface.
3) Very small amount of mature trabecular bone remained around Ti in "ovx" as seen in distal region of femurs, whereas the thickness of surrounding bone rapidly increased at 1 6 weeks. A greater amount of mature bone was found close to Ti m "sham" compared to that in "ovx". These findings suggest that the bone reaction, especially in the bone-implant interface, is different between HA and Ti in cases of osteoporosis.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 川本苗子: "骨粗鬆症ラットにおけるインプラント周囲骨組織の経時的変化-インプラント埋入後に骨粗鬆症を発症した場合-"四国歯学会雑誌. 12. 173-188 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Naeko Kawamoto: "Chronological change in the bone structure around implants in rats with osteoporosis : a case of osteoporosis induced after implantation"Shikoku Dental Research. 10(1). 1-10 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 川本苗子: "骨粗鬆症ラットにおけるインプラント周囲骨組織の経時的変化-インプラント埋入後に骨粗鬆症を発症した場合-"四国歯学会雑誌. 12・1. 173-188 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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