Comparative study of Tc-99m and Ga-67 scintigraphy in oral squamous cell carcinoma with doubted mandibular invasion. - Mandibulectomy cases -
Project/Area Number |
10671902
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Iwate Medical University |
Principal Investigator |
SEGAWA Kiyoshi Iwate Medical University, School of Dentistry, Department of Oral and Maxillofacial Surgery. Clinical stuff (nonregular Lecturer), 歯学部, 助手 (20196934)
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Project Period (FY) |
1998 – 1999
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Project Status |
Completed (Fiscal Year 1999)
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Budget Amount *help |
¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1999: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 1998: ¥300,000 (Direct Cost: ¥300,000)
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Keywords | oral squamous cell carcinoma / mandibulal invasion / ィイD199mィエD1Tc-scintigraphy / ィイD167ィエD1Ga-scintigraphy / recurrence / prognosis / ^<99m>Tcシンチグラフィ / ^<67>Gaシンチグラフィ / 腫瘍シンチグラフィー / 骨シンチグラフイー / 手術 |
Research Abstract |
Mandibular invasion caused by oral squamous cell carcinoma is usually detected by roentogenography, computed tomography, and magnetic resonance imaging. In detected and/or suspected cases of invasion of the mandible, Tc-99m (ィイD199mィエD1Tc) scintigraphy is useful in clarifying the extent of the mandibular invasion of the tumor, when used in conjunction with Ga-67 (ィイD167ィエD1Ga) scintigraphy evaluation of possible tumor activity. From 1989 to 1997, twenty-four patients with oral and/or central squamous cell carcinoma suspected of invading the mandible were investigated with ィイD199ィエD1mTc and ィイD167ィエD1Ga scintigraphy. Sites of tumor were; 14 lower gingivae, 3 buccal mucosae, 3 mouth floors, 4 central carcinomas of the mandible. Surgical procedures included; marginal mandibulectomy (n=11), segmental mandibulectomy (n=9), and hemimandibulectomy (n=4). Four recurrent patients had an accumulation of both ィイD199mィエD1Tc and ィイD167ィエD1Ga scintigraphy before treatment. Three patients had undergone marginal mandibulectomy, and one patient received a hemimandibulectomy. Two patients with no histological mandibular invasion had no uptake of ィイD167ィエD1Ga and no roentogenographic bone absorption. Two of four patients with high accumulation of ィイD167ィエD1Ga died of the disease. A comparative study of ィイD199mィエD1Tc and ィイD167ィエD1Ga scintigraphy might improve the possibility for the prediction of tumor reccurence after surgery. In addition, it is useful in determing the best surgical procedure for the mandible.
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Report
(3 results)
Research Products
(10 results)