AMAGASA Mituo Tokyo Med. & Dent. Univ., School of Dentistry, Professor, 歯学部, 教授 (00014332)
OIDA Shinichiro Turumi Univ., School of Dentistry, Associate Professor, 歯学部, 助教授 (10114745)
NAKAKITA Nobuaki Kitasato Univ., School of Medicine, Associate Professor, 医学部, 助教授 (40180260)
|Budget Amount *help
¥2,700,000 (Direct Cost : ¥2,700,000)
Fiscal Year 1999 : ¥700,000 (Direct Cost : ¥700,000)
Fiscal Year 1998 : ¥2,000,000 (Direct Cost : ¥2,000,000)
1. Epidemiological study of 467 cleft lip and /or plate patients in Kitasato Univ. 25 years In the past: (1) Sex, (2) Age when operating, (3) Birthplace, (4) Multifactorial diseases, (5) Birth Order, (6) Lineage appearance rate & Brothers appearance rate, (7) Classification of Cleft (bilateral/unilateral cleft lip and palate, cleft hard and soft palate, cleft soft palate, submucous cleft palate), (8) Change at annuals of operation number.
Results; (1) Sex- male: female=249:217 (2) Age when operating- average: seven months a years old, (3) Birthplace- Kanagawa Pref, 78.4%, (4) Multifactorial diseases- 92cases 19.7%, (5) Birth Order- the first child: 191cases 40.9%, the second child: 203cases 43.5%, the third child: 67cases 14.3%, the fourth child: 5cases 1.1%, (6) Lineage appearance rate -16.5%, (7) bilateral/unilateral cleft lip and palate: 254cases 43.5%,, cleft hard and soft palate: 73cases 15.6%, cleft soft palate: 93cases 19.9%, submucous cleft palate: 10cases 10.1%, (8) Change at annuals of operation number-average during year: 20cases.
2. Investigation of multifactorial diseases appearance rate in each cleft and lineage appearance rate: (1) Multifactorial diseases-Total appearance rate: 94/467 20.1%, cleft lip and palate: 29/251 11.6%, cleft hard and soft palate: 28/55 50.9%, cleft soft palate: 24/92 26.1%, submucous cleft palate: 9/48 18.8%. (2) Lineage appearance rate-36/218 16.5%. High multifactorial diseases appearance rate (61/195 31.1%) was observed in isolated cleft palate.
3. Candidate gene analysis of cleft lip and /or plate in Japanese patients:
We are examining HLA class I (HLA-B) and class II alleles (HLA-DRB1 and DPB1) in Japanese patients with CL/P using high resolution DNA typing methods. At present, the result has not come out yet.