|Budget Amount *help
¥2,700,000 (Direct Cost : ¥2,700,000)
Fiscal Year 2001 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 2000 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1999 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 1998 : ¥1,200,000 (Direct Cost : ¥1,200,000)
The purpose of the present study was to investigate (1) effect of voluntary running exercise on the exocrine pancreas and (2) effect of cholecystokinin (CCK) antagonist (CR1505) administration on the chronic exercise induced hypertrophy of acinar cells in rats.
(1) Female F344 rats were divided into control, compulsory trained, and voluntary trained groups. The compulsory trained rats were exercised for 60 min on a treadmill (35m/ min), 5 days a week, for 8 weeks. The voluntary trained rats were exercised on a voluntary basis on a wheel ergometer with a load of 30% of their body weight every day. Mean running distance for the voluntary trained group was 5. 2Km. Pancreatic weight, protein content, and enzyme activity in the compulsory and voluntary trained groups were significantly higher than in the control group. Significant correlations between running distance and these parameters of the exocrine pancreas were observed. These results suggest that exocrine pancreas function may be acc
elerated by increases of daily total physical activity.
(2) Female F344 rats were divided into control, CR1505, trained, CR1505+trained groups. The trained rats were exercised same as the compulsory trained rats of (1). CR1505 was administrated for 10mg/kg BW, 5 days a week, for 8 weeks. Pancreatic weight gain and pancreatic acinar cells hypertrophy were observed in the trained rats. But these changes were not recognized in CR1505+trained rats. Protein content and zymogen granulus increased in the trained and CR1505+trained rats. There are no significant differences in total DNA content in whole pancreas among the 4 groups. These results suggest that chronic exercise induced hypertrophy was mediated by CCK. However, chronic exercise induced increases of protein synthesis and storage were mediated by not only CCK. There must be another system of acceleration of the exocrine pancreas induced by chronic exercise.