Effect of cooling of the prefrotal and premotor areas on thedischargepattern of neurons in the lateral crebellar nucleus.
Project/Area Number |
10680763
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
神経・脳内生理学
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Research Institution | Shiga University of Medical Science |
Principal Investigator |
JINNAI Kohnosuke Shiga University of Medical Science, Dept.Physiology-1, Professor, 医学部, 教授 (80127026)
|
Co-Investigator(Kenkyū-buntansha) |
IJICHI Yoshichika Shiga University of Medical Science, Dept.Physiology-1, Research Associates, 医学部, 助手 (50106829)
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Project Period (FY) |
1998 – 2000
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Project Status |
Completed (Fiscal Year 2000)
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Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥2,100,000 (Direct Cost: ¥2,100,000)
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Keywords | lateral cerebellar nucleus / unit activity / visual response / monkey / cooling / prefrontal area / cognitive function / premotor area |
Research Abstract |
The followings were observed in our preceding experiments. Neurons in the caudal part of the lateral cerebellar nucleus (LCN) in monkeys were found to receive cerebral input from the prefrontal (PF) and rostral premotor (6DR) areas and to project to the medial portion of the motor thalamus, which had been reported to project on the premotor area. During the performance of delayed conditional GO/NO-GO task, almost all of these neurons showed short latency (55-110ms) response to visual signal, which was frequently followed by later visual response. LCN neurons with input from the motor and the caudal premotor areas but without that from PF nor 6DR located in more rostral part and project to more lateral motor thalamus relaying area4. Some of them showed the later visual response but none showed the early one. Present study revealed that cooling of a part of PF ventral to the principal sulcus (PSv) and of 6DR decrease the intensity of short latency visual response of the caudal LCN neurons with input from each area. It was also made obvious that the later visual response was differential according to the meaning of the signal, i.e., GO or NOGO, in more than half cases.(In this task, GO is instructed by the second light with the same color as the first one and NO-GO is by different one, so the GO and NO-GO signals are physically the same) It is possible that the later response can be generated by input from premotor area, which is influenced by the early output from the caudal LCN neurons. The short latency visual response which is dependent on the PF input may be starting signal for the following cognitive or discriminative neural mechanism by cerebello-cerebral linkage.
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Report
(4 results)
Research Products
(3 results)