| Project/Area Number |
11460143
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied veterinary science
|
|---|
| Research Institution | HOKKAIDO UNIVERSITY |
|---|
Principal Investigator |
TAKASHIMA Ikuo Hokkaido Univ., Grad. School of Vet. Med., Prof., 大学院・獣医学研究科, 教授 (30002083)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kenichi Hokkaido Inst, of Pub. Health., Sect., of Med Zool, Head, 疫学部, 科長
IWASAKI Takuya Nagasaki Univ., Inst. of Trop. Med., Prof., 熱帯医学研究所, 教授 (90146027)
KARIWA Hiroaki Hokkaido Univ., Grad. School of Vet. Med., Assoc. Prof., 大学院・獣医学研究科, 助教授 (70224714)
MIZUTANI Tetsuya Hokkaido Univ., Grad. School of Vet. Med., Instr., 大学院・獣医学研究科, 助手 (70281681)
MARUYAMA Tsutomu Azabu Univ., Dept. Env. Health., Prof., 環境保健部, 教授 (50239159)
|
|---|
| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥15,600,000)
Fiscal Year 2001: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2000: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1999: ¥7,100,000 (Direct Cost: ¥7,100,000)
|
|---|
| Keywords | Viral encephalitis / Tick-borne encephalitis / Origin / Pathogenicity / ウイルスの起源 |
|---|
| Research Abstract |
We conducted epidemiclogical study to specify the endemic area of tick-borne encephalitis (TBE), evaluated the pathogenicity of TBE virus Hokkaido strain and tested the efficacy of European TBE vaccine to Hokkaido TBE virus strain. We also performed phylogenetic study of TBE virus Hokkai strains to estimate the origin.
The results showed that TBE virus distribute in southern part of Hokkaido from the positive antibody results in dog and horse sera. Reservoir animals of TBE virus in Hokkaido were found to Clethrionomys rufocanus and Apodemus speciosus from virus isolation result. TBE virus Hokkaido strains possessed common pathogenicity shared among TBE virus strains. TBE virus Hokkaido strain diverged from ancestor virus in Far East several hundred years ago. Another subtype of TBE virus Siberian subtype was found to distribute in Siberian area of Russia. European type TBE virus vaccine was found to be efficacious to TBE virus Hokkaido, Far Eastern and Siberian strains. Monoclonal antibodies against TBE virus Hokkaido strain were produced and found to be useful for diagnosis.
|
