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Development of lifestyle-modification assessing system of preventive medicine by comprehensive health-index

Research Project

Project/Area Number 11557029
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Hygiene
Research InstitutionOsaka University

Principal Investigator

MORIMOTO Kanehisa  Osaka Unive., Grad.Sch.of Med., Prof., 医学系研究科, 教授 (20143414)

Co-Investigator(Kenkyū-buntansha) IOKA Tatsuya  Osaka Med., Center for Cancer and Cardiovascu., Dis., 医師(研究職)
ISHIKAWA Hideki  Osaka Med., Center for Cancer and Cardiovascu., Dis., 医長(研究職)
TAKESHITA Tatsuya  Osaka Univ., Grad.Sch.of Med., Assoc.Prof., 医学系研究科, 助教授 (20150310)
TSUJITA Satoshi  Osaka Univ., Grad.Sch.of Med., Assist.Prof., 医学系研究科, 助手 (90314319)
KOIZUMI Hideaki  Hitachi Ltd., Advanced research Lad., President, 基礎研究所, 所長(研究職)
丸山 総一郎  大阪大学, 医学系研究科, 助教授 (70219567)
中村 清一  大阪府立公衆衛生研究所, 主任研究員 (80167551)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥10,800,000 (Direct Cost: ¥10,800,000)
Fiscal Year 2001: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2000: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1999: ¥3,100,000 (Direct Cost: ¥3,100,000)
KeywordsColonic adenoma / Colon cancer / Lifestyle / Exercise / Fat / Random sampling / Clinical trial / Nutrition therapy / 大腸腺腫
Research Abstract

The subjects were workers m a camera maker company Lifestyle information was obtained by a self-administered questionaire m the annual health-Check-ups, Healthy lifestyles, or "good health practices" examined were, 1) not, smoking, 2) not drinking, too, much alcohol, 3)r doing physical exercise regularly, 4) sleeping more than 6 h per night, 5) keeping, nutritional, balance In meals, G) not working longer than 10 h a day, 7) having breakfast everyday, and 8) not having too much perceived stress Healthiness of lifestyles was assessed,by calculating Health Practice Index (HPI), the number of good health practices they do : The persons were usually categorized into 3 groups having good, moderate and poor lifestyles by HPI
The general health status was assessed by the ridit analysis of the incidence of abnormal values sin bloody biochemistry, blood-pressure, and urine tests of multiphasic health check-ups. The general health wash found to decrease with aging ; but to vary a lot according to their lifestyles For example, the mean level of somatic health of the persons having poor lifestyles m the 20's was about the same that of those with good lifestyles in the 40's. According to the results of G-yr follow-up of 2148 workers, the unhealthy workers were found to have had significantly higher asks for the developments of chronic diseases such as heart attack, liver disease, and diabetes

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Morimoto, K.: "Lifestyles and mental health status are associated with natural killer cell and lymphokine-activated killer cell activities."Sci.Total Environ.. 270. 3-11 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Morimoto, K.: "Relations between lifestyles and lifestyle-related diseases."Asian Med.J.. 43. 460-469 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshita, T.: "The ALDH2 genotype alcohol intake and liver function biomarkers among Japanese male workers."Hum.Genet.. 106. 589-593 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeuchi, T.: "Mechanism of oxidative DNA damage induction in a strict anaerobe. Prevotella melaninogenica."FEMS Microbiol.Lett.. 192. 133-138 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Lu, Y.: "Effects of (-)-Epigallocatechin Gallate (EGCG) on DNA Strand Breaks as Evaluated by single-cell Gel Electrophoresis (SCG) in Human Lymphocytes."Environ.Health Prev.Med.. 5. 150-154 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Obata, A.: "Acute effects of alcohol on hemodynamic changes during visual stimulation assessed using 24-channel near-infrared spectroscopy."Psychiat.Res.Neuroimaging. 123. 145-152 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 森本 兼曩: "現代医学と社会(分担:ストレスと健康障害)(井村裕夫, 高久史麿編)"岩波書店. 250 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Morimoto, K., Takeshita, T., Inoue-Sakurai, C., Maruyama, S.: "Lifestyles and mental health status are associated with natural killer cell an lymphokine-activated killer cell activities"Sci.Total Environ.. 270. 3-11 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] morimoto, K., Takeshita, T.: "Relations between lifestyles and lifestyle-related diseases"Asian Med.J.. 43. 460-469 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeshita, T., Yang, X., Morimoto, K.: "the ALDH2 genotype alcohol intake and liver function biomarkers among japanese male workers"Hum.Genet.. 106. 589-593 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takeuchi, T., Kato, N., Watanabe, K., Morimoto, K.: "Mechanism of oxidative DNA damage induction in a strict anaerobe. Prevotella melaninogenica"FEMS Microbiol.Lett.. 192. 133-138 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Lu, Y., Morimoto, K., Takeshita, T., Takeuchi, T., Saito, T.: "Genotoxic effects of α-endosulfan and β-endosulfan on human HepG2 cells"Environ.Health Perspect.. 108. 559-561 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Obata, A., Morimoto, K., Sato, H., Maki, A., Koizumi, H.: "Acute effects of alcohol on hemodynamic changes during visual stimulation assessed using 24-channel near-infrared spectroscopy"Psychiat.Res.Neuroimaging. 123. 145-152 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Morimoto, K.: "Stress to kenko-shogai. H, Imura., H, Takaku. gendai igaku to shakai (Tokyo)"Iwanami. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Morimoto, K.: "Lifestyles and mental health status are associated with natural killer cell and lymphokine-activated killer cell activities"Sci Total Environ. 270. 3-11 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeshita, T.: "Association of the ADH2 genotypes, with skin response atter ethanol exposure in Japanese male university students"Alcohol Clin Exp Res. 25. 1264-1269 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Li, D.: "Formamidopyrimidine-DNA glycosylase enhances arsenic-induced DNA strand breaks detected with the alkaline comet assay in PHA-stimulated and unstimulated human lymphocytes"Environ Health Perspect. 109. 523-526 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ioka, T.: "Study of prevention of colorectal cancer through lifestyle modification : an introduction to the protocol"Asian Pacific J Cancer Prev. 2. 233-236 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石川秀樹: "家族性腫瘍に対する化学予防"臨床外科. 56. 617-621 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toda, M.: "The effect of the weight reduction on the salivary cortisol levels of Jndo players"Environ.Health Prev.Med.. 6. 113-116 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石川秀樹: "大腸ポリープと言われたら読む本"PHP社. (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeshita,T.: "Accumulation of hemoglobin-associated acetaldehyde with habitual alcohol drinking in the atypical ALDH2 genotype."Alcohol Clin.Exp.Res.. 24. 1-7 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inoue-Sakurai,C.: "Posttraumatic Stress and Lifestyles Are Associated with Natural Killer Cell Activity in Victims of the Hanshin-Awaji Earthquake in Japan."Prev.Med.. 31. 467-473 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fukuda,S.: "Effect of the Hanshin-Awaji Earthquake on posttraumatic stress, lifestyle changes, and cortisol levels of victims."Arch.Environ.Health.. 55. 121-125 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Pan,J.B.: "P300 habituation from auditory single-stimulus and oddball paradigms."Int.J.Psychophysiol.. 37. 149-153 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Lu,Y.: "Genotoxic effects of α-endosulfan and β-endosulfan on human Hep G2 cells."Environ.Health Perspect.. 108. 559-561 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takeuchi,T.: "Mechanism of oxidative DNA damage induction in a strict anaerobe, Prevotella melaninogenica. FEMS Microbiology letters"FEMS Microbiol.Lett.. 192. 133-138 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 森本兼曩: "井村裕夫・高久史磨 編:現代医学と社会(分担:ストレスと健康障害)"岩波書店. (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 石川秀樹: "佐々木敏・等々力英美 編:EBN入門(分担:食物繊維と大腸癌予防)"第一出版. (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yang,X.: "Prevalence of Helicobacter pylori Infection Japan : Relation to Educational Levels and Hygienic Conditions"Environ.Health Prev.Med.. 4. 202-206 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeuchi,T.: "Induction of oxidative DNA damage in anaerobes"FEBS Letters. 450. 178-180 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeshita,T.: "Self-reported alcohol-associated symptoms and drinking behavior in three ALDH2 genotypes among Japanese university students"Alcohol Clin.Exp.Res.. 23. 1065-1069 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Murata,M.: "Genotype Difference of Aldehyde Dehydrogenease2 Gene in Alcohol Drinkers Influences the Incience of Japanese Colorectal"Jpn.J.Cancer Res.. 90. 711-719 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fukuda,S.: "Posttraumatic Stress and Change in lifestyle among the Hanshin-Awaji Earthquake Victims"Prev.Med.. 29. 147-151 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishikawa,H.: "Prevention of Infections Complications subsequent to Endoscopic treatment of the colon and rectum"J.Infect Chemother. 5. 86-90 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishikawa,H.: "Familial Cancer and Prevention"Wiley-Liss,Inc.. 559 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 森本兼ひさ: "現代的ストレスの課題と対応"至文堂. 254 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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