| Project/Area Number |
11557168
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Periodontal dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAGATA Toshihiko The University of Tokushima, School of Dentistry, Professor, 歯学部, 教授 (10127847)
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| Co-Investigator(Kenkyū-buntansha) |
ASANO Masahiro The University of Tokushima, Dental Hospital, Research Associate, 歯学部・附属病院, 助手 (30335822)
YAMAUCHI Noriyuki The University of Tokushima, School of Dentistry, Research Associate, 歯学部, 助手 (10253212)
KIDO Jun-ichi The University of Tokushima, School of Dentistry, Associate Professor, 歯学部, 助教授 (10195315)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥5,100,000 (Direct Cost: ¥5,100,000)
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| Keywords | gingival crevicular fluid / osteopontin / osteocalcin / calprotectin / P1CP / bone resorption / periodontal disease / 骨吸收 / 歯周炎 |
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| Research Abstract |
To determine the clinical marker reflecting alveolar bone resorption in periodontal disease, osteocalcin (OCN), osteopontin (OPN), carboxy terminal propeptide of type I procollagen (P1CP), and calprotectin (CPT) were biochemically quantified using gingival crevicular fluid (GCF) from periodontitis patients. These markers appeared in GCF from periodontitis patients, whereas they were also detected a little in GCF from healthy subjects. The levels of P1CP and CPT strongly correlated with clinical inflammatory indicators such as gingival index and probing depth. Moreover, P1CP and CPT correlated with bleeding on probing (BOP) which is associated with the disease activity. OPN and OCN weakly correlated with the inflammatory markes. P1CP showed high level in GCF from bone resorptive area. Taken together, it is suggested that CPT may be a potent marker reflecting inflammatory activity and P1CP may be a potent marker reflecting bone resorption in periodontal disease.
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