| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Research Abstract |
To study preventive effect of seaweed on the disorder of blood circulation and its application to food, several edible seaweed were examined on blood anti-coagulation erythrocyte deformabilrty, and platelets anti-aggregation by in vitro and in vivo experiments.
By in vitro experiment, among several edible algae, Hijikia fusiformis (Hijiki), Undaria pinnatifida (Wakame), Monostroma nitidium (Hitoegusa) and Laminaria japonica (Makombu) lowered the blood coagulation time to 93 %, 95 %, 97 % and 98 %, respectively. Among seaweed components, minerals of H. fusiformis, U. pinnatifida, M nitidum, L. japonica increased the erythrocyte deformability 18 %, 14 %, 14 %, 11 %, respectively. These effects were caused mainly by the Ca/Mg ratio. Phospholipid, κ-carrageenan, porphyran, and D-cysteinolic acid of M. nitidum also increased the erythrocytes deformability. Monostraoma minerals were useful not only increase the erythrocytes deformability but also inhibit the decrease of its deformability. When tested by animal experiments. Monostrom minerals inhibited the decrease of erythrocyte deformability, shortened APTT and inhibited the platelets aggregation activity. Cr, Se and Mg in the minerals were assumed to be effective factor. Using M. nitidum, new food "Nori tukudani " having the effects of minerals and D-cysteinolic acid that have platelets anti-aggregating effects were developed. Therefore, usage of M. nitidum in daily eating habits improves health from the view point of blood fluidity.
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