| Project/Area Number |
11670291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
ISHIMOTO Akinori Institute for virus search department of viral oncology, Kyoto University Professor, ウイルス研究所, 教授 (50073127)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Hiroyuki Institute for virus search department of viral oncology, Kyoto University, associate Professor, ウイルス研究所, 助教授 (80281731)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | opportunistic cancer / Retrovirus / Murine Leukemia Virus / Murine AIDS virus |
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| Research Abstract |
Fv-4 is a mouse gene that dominantly confers resistance to infection with Friend murine leukemia virus(F-MuLV). To confirm the immunological effect on the resistance in adolescent mice with the Fv-4^<r/r> and Fv-4r^<r/-> genotypes, we examined the effect of an immunosuppressant drug, FK506, on the resistance. The mice with the Fv-4^<r/r> genotype treated with FK506 still showed resistance, but the mice with the Fv-4^<r/-> genotype became highly sensitive to F-MuLV infection.
Recently we found that N-tropic ecotropic MuLV isolated from SL-mice induced myeloid leukemia in CBA nude mice(Ntype strain).
We infected NB-tropic anemia-inducing Friend MuLV to newborn and young-adult Syrian hamsters. About half of the hamsters neonatally infected manifested interrupted growth, presenting runting syndrome-like desease or wasting desease, and all the runt hamsters died within 4 weeks of the inoculation, while the remaining hamsters showed no obvious sings of disease such as interrupted growth, leukemia or neurological disease.
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