IMMUNO-EPIDEMIOLOGIC STUDY FOR JAPANESE CEDAR POLLINOSIS
| Project/Area Number |
11670382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
OZASA Kotaro KYOTO PREFECTURAL UNIVERSITY OF MEDICIENE, FACULTY OF MEDICIENE ASSOCIATE PROFESSOR, 医学部, 助教授 (20204191)
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| Co-Investigator(Kenkyū-buntansha) |
DEJIMA Kenji KYOTO PREFECTURAL UNIVERSITY OF MEDICIENE, FACULTY OF MEDICIENE ASSISTANT PROFESSOR, 医学部, 講師 (80217447)
TAKENAKA Hiroshi OSAKA MEDICAL COLLEGE, FACULTY OF MEDICIENE PROFESSOR, 医学部, 教授 (40137162)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | JAPANESE CEDAR POLLINOSIS / IMMUNOLOGY / EPIDEMIOLOGY / IgE ANTIBODY / ALLERGY / FATTY ACIDS / CYTOKINES / サイトカメン / インターロイキン / インターフェロンガンマ / 血清脂肪酸分画 |
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| Research Abstract |
Children of primary and junior-high schools in a rural town in the southern Kyoto Prefecture were examined for their symptoms and serum antigen-specific IgE antibody every May or June during 1994-2000. Dispersion of Japanese cedar pollen (JCP) was measured in the town by Durham's method, and the counts varied from 165 to 5941 during the years.
Proportion of sensitized children to JCP ranged from 43 to 56% during 1994-98, and proportion of Japanese cedar pollinosis was 14-21%. The pollen counts were correlated to those proportions. Spearman's ρ=0.82 (p=0.04) for the proportion of being positive CAP-RAST score>=2, 0.60 (p=0.20) for score>=4, 1.00 (p<0.001) for prevalence of Japanese cedar pollinosis. Prevalence of children with symptoms seemed to be almost similar for a specific level of JCP-IgE antibody despite various counts of dispersed pollen. It was about 10% for CAP-RAST score 0, 20% for score 2, 30% for score 3, and 40-60% for score 4 or higher.
Serum levels of fatty acid fraction, IL4, IL10, IL18, and INFγ were measured for four groups (1 : symptoms+and CAP-RAST score>=4, 2 : symptoms+and score 2-3, 3 : symptoms-and score 2-3, 4 : symptoms-and score 0) to evaluated the association between those serum levels and the potential emerging symptoms. Each group consisted of 10 children who were randomly sampled. There were no significant differences among those levels. Form the comparison of Groups 2 and 3, the levels of saturated fatty acid, IL4 and IL18 could be higher for children with symptoms than for those without symptoms among those being moderately positive to JCP.
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Report
(3 results)
Research Products
(6 results)
