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IMMUNO-EPIDEMIOLOGIC STUDY FOR JAPANESE CEDAR POLLINOSIS

Research Project

Project/Area Number 11670382
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKYOTO PREFECTURAL UNIVERSITY OF MEDICINE

Principal Investigator

OZASA Kotaro  KYOTO PREFECTURAL UNIVERSITY OF MEDICIENE, FACULTY OF MEDICIENE ASSOCIATE PROFESSOR, 医学部, 助教授 (20204191)

Co-Investigator(Kenkyū-buntansha) DEJIMA Kenji  KYOTO PREFECTURAL UNIVERSITY OF MEDICIENE, FACULTY OF MEDICIENE ASSISTANT PROFESSOR, 医学部, 講師 (80217447)
TAKENAKA Hiroshi  OSAKA MEDICAL COLLEGE, FACULTY OF MEDICIENE PROFESSOR, 医学部, 教授 (40137162)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsJAPANESE CEDAR POLLINOSIS / IMMUNOLOGY / EPIDEMIOLOGY / IgE ANTIBODY / ALLERGY / FATTY ACIDS / CYTOKINES / サイトカメン / インターロイキン / インターフェロンガンマ / 血清脂肪酸分画
Research Abstract

Children of primary and junior-high schools in a rural town in the southern Kyoto Prefecture were examined for their symptoms and serum antigen-specific IgE antibody every May or June during 1994-2000. Dispersion of Japanese cedar pollen (JCP) was measured in the town by Durham's method, and the counts varied from 165 to 5941 during the years.
Proportion of sensitized children to JCP ranged from 43 to 56% during 1994-98, and proportion of Japanese cedar pollinosis was 14-21%. The pollen counts were correlated to those proportions. Spearman's ρ=0.82 (p=0.04) for the proportion of being positive CAP-RAST score>=2, 0.60 (p=0.20) for score>=4, 1.00 (p<0.001) for prevalence of Japanese cedar pollinosis. Prevalence of children with symptoms seemed to be almost similar for a specific level of JCP-IgE antibody despite various counts of dispersed pollen. It was about 10% for CAP-RAST score 0, 20% for score 2, 30% for score 3, and 40-60% for score 4 or higher.
Serum levels of fatty acid fraction, IL4, IL10, IL18, and INFγ were measured for four groups (1 : symptoms+and CAP-RAST score>=4, 2 : symptoms+and score 2-3, 3 : symptoms-and score 2-3, 4 : symptoms-and score 0) to evaluated the association between those serum levels and the potential emerging symptoms. Each group consisted of 10 children who were randomly sampled. There were no significant differences among those levels. Form the comparison of Groups 2 and 3, the levels of saturated fatty acid, IL4 and IL18 could be higher for children with symptoms than for those without symptoms among those being moderately positive to JCP.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Ozasa K. et al: "Exposure to Japanese cedar pollen in early life and the risk of subsequent sensitization to Japanese cedar pollen"J Epidemiol.. 10. 42-47 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 出島健司 他: "スギ花粉症の疫学"アレルギー科. 9. 136-140 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ozasa K, Dejima K, Watanabe Y and Takenaka H: "Exposure to Japanese cedar pollen in early life and subsequent sensitization to Japanese cedar pollen"J Epidemiol. 10. 42-47 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Dejima K, Yasuda S, Ozasa K, Takenaka H and Fujieda S: "Epidemiology of Japanese cedar pollinosis [in Japanese]"Arerugi-ka. 9. 136-140 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Dzasa K et al: "Exposure to Japanese cedar pollen in early life and the risk of subsequent sensitization to Japanese cedar pollen."J Epidemiol. 10. 42-47 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 出島健司 他: "スギ花粉症の疫学"アレルギー科. 9. 136-140 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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