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Mapping of genes responsible for ulcerative colitis using new microsatellite markers within the HLA region.

Research Project

Project/Area Number 11670484
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionNiigata university

Principal Investigator

SUGIMURA Kazuhito  Niigata Univ., Medical Hospital, 3rd Dept. of Int.Med., Instructor, 医学部・附属病院, 助手 (80270940)

Co-Investigator(Kenkyū-buntansha) ASAKURA Hitoshi  Niigata Univ., Faculty of Medicine, Professor, 医学部, 教授 (20051451)
INOKO Hidetoshi  Tokai Univ., Faculty of Medicine, Professor, 医学部, 教授 (10101932)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsJapanese / MICA gene (major histocompatibility complex class I chain-related gene A) / Population study / STR (short tandem repeat) / Ulcerative colitis / MHCクラスI関連遺伝子 / 三塩基反復配例多型
Research Abstract

MHC class I chain-related gene A (MICA) has been found near the HLA-B gene. The MICA molecule is exclusively expressed on gastrointestinal epithelium and recognized by intestinal epithelial gd T cells, where it exhibits a triplet repeat polymorphism in the transmembrane region. We investigated the possible correlation between MICA genetic polymorphism and ulcerative colitis (UC). Eighty-three patients with UC and 132 unrelated controls were included in this study. All subjects were Japanese. A triplet repeat polymorphism in the transmembrane region of the MICA was determined by direct sequencing procedures after amplification by a polymerase chain reaction. A significantly higher allele and phenotype frequencies of MICA A6 allele were observed in patients with UC than controls (allele frequency : Pc=0.000011, phenotype frequency : Pc =0.0049 odds ratio=2.62). A6 homozygous patients with UC showed significantly earlier onset of UC than patients without the A6 allele (Pc=0.0042). Phenotypes of MICA A6 allele in Japanese are closely related to the disease susceptibility and behavior in UC.Examinations of MICA polymorphism in other ethnic groups may provide important information about the locus of primary responsible gene for UC.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Sugimura K,: "A close relationship of triplet repeat polymorphism in the MHC class I chain-related gene A (MICA) to the disease susceptibility and behavior in ulcerative colitis."Tissue Antigens. 57(1). 9-14 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ishizuka K,: "Influence of Interleukin-10 on the Interleukin-1 receptor antagonist (IL-1ra)/Interleukin-1beta ratio in the colonic mucosa of ulcerative colitis."Digestion. 63(supple1). 22-27 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sugimura K,: "Gastrointestinal function, regulation and disturbances."In : Tsuchiya M, Matsuo Y, Kasuya Y, Muto T, eds. Elsevier Science K.K.Tokyo : (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sugimura K Masao Ota, Jun Matsuzawa, Yoshihiko Katsuyama, Kisei Ishizuka, Tutomu Mochizuki, Nobuhisa Mizuki, Terasu Homma, Hidetoshi Inoko Hitoshi Asakura: "A close relationship of triplet repeat polymorphism in MHC class I chain-related gene A (MICA) to the disease susceptibility and behavior in ulcerative"Tissue Antigens. 57(1). 9-14 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sugimura K, Masao Ota, Jun Matsuzawa, Yoshihiko Katsuyama, Kisei Ishizuka, Tutomu Mochizuki, Nobuhisa Mizuki, Terasu Homma, Hidetoshi Inoko, Hitoshi Asakura: "Triplet repeat polymorphism of MHC class I chain-related gene A (MICA) in Japanese patients with ulcerative colitis."Tsuchiya M, Matsuo Y, Kasuya Y, Muto T, eds. Gastrointestinal function, regulation and disturbances. Tokyo : Elsevier Science K.K.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kisei Ishizuka Kazuhito Sugimura, Terasu Homma, Jun Matsuzawa, Tsutomu Mochizuki, Masaaki Kobayashi, Kouji Suzuki, Kazuaki Otsuka, Kazunori Tashiro, Osamu Yamaguchi and Hitoshi Asakura: "Influence of Interleukin-10 on the Interleukin-1 receptor antagonist (IL-1ra)/Interleukin-1beta ratio in the colonic mucosa of ulcerative colitis."Digestion. 63 (supple 1). 22-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sugimura K,: "A close relationship of triplet repeat polymorphism in the MHC class I chain-related gene A (MICA) to the disease susceptibility and behavior in ulcerative colitis."Tissue Antigens. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ishizuka K,: "Influence of Interleukin-10 on the Interleukin-1 receptor antagonist (IL-1ra)/Interleukin-1beta ratio in the colonic mucosa of ulcerative colitis."Digestion. 63(supple1). 23-27 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sugimura K,: "Gastrointestinal function, regulation and disturbances."In : Tsuchiya M,Matsuo Y,Kasuya Y,Muto T,eds.Elsevier Science K.K.Tokyo :. in press (2001)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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