| Project/Area Number |
11670510
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | KOCHI MEDICAL SCHOOL |
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Principal Investigator |
ONISHI Saburo Kochi Medical School, First Department of Internal Medicine, Professor, 医学部, 教授 (60136380)
|
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| Co-Investigator(Kenkyū-buntansha) |
SAIBARA Toshiji Kochi Medical School, First Department of Internal Medicine, Research Associate, 医学部・附属病院, 講師 (60145125)
TANIGUCHI Taketoshi Kochi Medical School, Medical Research Center, Associate Professor, 医学部, 助教授 (90127944)
小野 正文 高知医科大学, 医学部・附属病院, 助手 (70304681)
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| Project Period (FY) |
1999 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1999: ¥2,100,000 (Direct Cost: ¥2,100,000)
|
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| Keywords | HEPATITIS B VIRUS / HEPATOCELLULAR CARCINOMA / TRANSACTIVATION / CARCINOGENESIS / tronsactivation / preS1 / TGF-α / transgenic mouse |
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| Research Abstract |
Development of liver fibrosis results in hepatic failure, hepatocellular carcinoma, esophageal varices, and spontaneous peritonitis, which are life-threatening complications in liver cirrhosis. However, patients with chronic hepatitis B virus infection occasionally develop hepatocellular carcinoma in non-cirrhotic liver. Therefore, some unknown mechanisms are assumed to be involved in the process of hepatocarcinogenesis in chronic hepatitis B virus infection. HBX protein has been one of the candidates of such factors. Here we showed for the first time that HBV preS1 is another candidate protein involved in such a mechanism. It affects the feedforward mechanism of EGF-EGFR signalling pathway profoundly involved hepatocarcinogenesis. This novel evidence is important since it may contribute to elucidate the complex mechanism of hepatocarcinogenesis and to find a therapeutic path of hepatocarcinoma in the near future.
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