Analysis of surfactant protein in the pathogenesis of asthma

• Project/Area Number: 11670588
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Dokkyo University School of Medicine
• Principal Investigator: SAGARA Hironori Dokkyo university School of Medicine, Lecturer, 医学部, 講師 (80275742)
• Co-Investigator(Kenkyū-buntansha): CHIBANA Naomi Dokkyo university School of Medicine, Instructor, 医学部, 助手 (10316573) ; NUMAO Toshio Dokkyo university School of Medicine, Lecturer, 医学部, 講師 (60172748) ; 中島 宏和 獨協医科大学, 医学部, 助手 (10275753)
• Project Period (FY): 1999 – 2001
• Project Status: Completed (Fiscal Year 2001)
• Budget Amount: ¥3,400,000 (Direct Cost: ¥3,400,000); Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000); Fiscal Year 2000: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: surfactant / SP-A / Bronchial Asthma / alveolar epithelial cell / lung injury / サイトカイン / 気道上皮

Research Abstract

Although numerous previous studies have revealed that bronchial asthma is an inflammatory disease of the airway, the pathogenesis of asthma has not been understood completely. Pulmonary surfactant is a highly surface active material which is mainly synthesized by alveolar type II cells and prevents alveolar collapse by reducing surface tensions at the air -liquid interface. Surfactant also covers the surface of small airways. Increased airway resistance in asthma could be partially due to a surfactant dysfunction. Our observations in the present study suggested that surfactant protein A may be secreted from the airways with allergic inflammation in a different manner from the alveoli. The increased levels of surfactant protein A and D may play a protective role in an allergic inflammation in the pathogenesis of bronchial asthma. And our results indicate that surfactant is intrinsically abnormal in chronically asthmatic lungs.

Research Products

• [Publications] 成 剛 他: "A 549 cells can express IL46 and stimulate eosinophils chemotaxis"Journal of Respiratory Cell Molecular Biology. 25. 212-218 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 成 剛 他: "Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma"European Respiratory Journal. 16. 831-835 (2000)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Cheng G et al: "A 549 cells can express IL-16 and stimulate eosinophils chemotaxis"Journal of Respiratory Cell Molecular Biology. 25. 212-218 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Cheng G et al: "Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma"European Respiratory Journal. 16. 831-835 (2000)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] 成 剛他: "A549 cells can express IL-16 and stimulate eosinophils chemotaxis"Journal of Respiratory Cell Molecular Biology. 25. 212-218 (2001)
• [Publications] 成 剛他: "Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma"European Respiratory Journal. 16. 831-835 (2000)
• [Publications] G Cheng: "Suppressive effects of SP-A on iononmi"Int Arch Allergy Immunol. 117・suppl1. (19**)
• [Publications] 成剛: "気管支喘息モデルにおける肺サーファクタント"臨床呼吸生理. 30・2. (19**)
• [Publications] 成剛: "慢性気管支喘息モデルにおける肺サ"呼吸. 18・2.
• [Publications] Takashi Ueda: "Change of surfactant subtype"日本界面医学会雑誌. 29・1. (19**)
• [Publications] Kumiya Sugiyama: "Altered surfactant system in rat lum"Dokkyo Journal of Medical Science. 26・1. (19**)
• [Publications] Takashi Ueda: "Effect of aging on surfactant"European Respiratory Journal. 15. (200*)