| Project/Area Number |
11671529
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
HIROSE Takaji Kansai Medical University,Faculty of medicine,Assistant professor, 医学部, 講師 (30189881)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAO Shinichi Kansai Medical University, Faculty of medicine, Associate professor, 医学部, 助教授 (10207714)
|
|---|
| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | NMDA receptor / Microdialysis / Neurotransmitter / Dopamine / Nucleus accumbens / Posterior cingulate / Retrosplenial cortices |
|---|
| Research Abstract |
Ketamine increased dopamine release in the nucleus accumbens, while pentobarbital decreased one. Furthermore, pentobarbital inhibited the ketamine-induced increase. Ketamine-induced c-Fos expression in the posterior cingulate cortex was inhibited by rimcazol but not by haloperidol, and was less in the NMDA receptor knockout mice.
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