| Co-Investigator(Kenkyū-buntansha) |
TERAO Kyoichi Kinki University, Otolaryngology, Assistant Professor, 医学部, 講師 (30278717)
千々和 圭一 久留米大学, 医学部, 講師 (20227317)
井上 要二郎 久留米大学, 医学部, 講師 (80176453)
坂本 菊男 久留米大学, 医学部, 助手 (70279222)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Research Abstract |
1. As for the patients of hypopharyngeal cancer, their p53, Ki-67, PD-ECGF and VEGF were investigated. These tumor markers had no significant relationship with absence/presence of regional or distant recurrence after the initial treatment. These markers were regarded as no effective prognostic factors.
2. To acquire better quality of life, laser debulking surgery prior to radiotherapy was conducted for T1T2 carcinoma of the hypopharynx. As a result, three-year local control rate, three-year larynx conservation rate, and three-year cause specific survival rate were 88%, 92%, and 92%, respectively. In addition, in patients who had undergone this procedure, few underwent tracheostomy, all could had oral diet from the next day of the operation, and none underwent total laryngectomy due to aspiration.
3. Since some patients with carcinoma of the hypopharynx visit the hospital complaining of origin unknown neck tumor, the relationship between the site of neck metastasis and primary origin was investigated. As a result, when neck metastases were squamous cell carcinomas and were confined to upper or middle jugular areas, affected-side tonsillectomy was regarded as one of reliable methods to know the primary origin.
4. Since carcinoma of the hypopharynx sometimes suffered from carcinoma of the tongue simultaneously, T1T2 carcinoma of the tongue was investigated. As a result, the prophylactic neck dissection would be indicated only when the patients and/or their family approved after detailed explanation about the advantage and disadvantage of this treatment. Supra-omohyoid neck dissection would be satisfactory as an initial treatment. Prognostic factors of neck metastases were depth of the invasion, vascular invasion, and muscular invasion of the primary tumor.
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