Effects of Intensive Training on Natural Killer Cell Function
| Project/Area Number |
11680058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
体育学
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| Research Institution | MEIJI UNIVERSITY |
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Principal Investigator |
SUZUI Masatoshi Meiji Univ., School of Business Administration, Prof., 経営学部, 教授 (10187693)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Takeshi Juntendo Univ., School of Health and Sports Science, Prof., スポーツ健康科学部, 教授 (70053098)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | natural killer cell / training / leukocyte / lytic units / epinephrine / cortisol / creatine kinase / adhesion molecule / ノルアドレナリン / コーチゾル |
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| Research Abstract |
Purpose : The impact of heavy training in competitive sports on natural killer (NK) cell function in eight female volleyball players of a college team was investigated, in a one-month period during their preparation for the game season. Methods : Subjects performed volleyball drills for five hours per day and six days per week. Four resting blood samples were taken respectively in the morning, pre-training (PRE), on the 10th day of training (DURING), one day before the end of training (END) and one week after training (POST). Data were analyzed using one-factor ANOVA with Bonferroni's post hoc test, Results and Discussion : Epinephrine, norepinephrine and cortisol concentrations remained unchanged from PRE levels, but plasma creatine kinase concentration increased at END (p=0.001). The number and percentage of circulating NK cells did not change throughout the experiment ; neither did other leukocyte subset counts. However, an overall decrease in NK cell cytotoxicity by 20.3±11.8% (p=0.02) was observed from PRE to END, recovering at POST.Lytic units per NK cell followed a similar pattern (p=0.002). The intensity of expression of CD44 on NK cells (CD3^-CD56^+) increased significantly at END (both, p<0.05). The expression of CD62L decreased at DURING and the expression of CD 18 dropped at POST (p<0.05). These results suggest that heavy training can decrease total NK cell cytotoxicity as well as the lytic activity per NK cell that was different response during and after acute exercise.
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Report
(3 results)
Research Products
(6 results)
