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Non-invasive studies of sensorimotor integration in human

Research Project

Project/Area Number 12210012
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

SHIBASAKI Hiroshi  Kyoto University, Faculty of Medicine, Professor, 医学研究科, 教授 (30037444)

Co-Investigator(Kenkyū-buntansha) FUKUYAMA Hidenao  Kyoto University, Faculty of Medicine, Professor, 医学研究科, 教授 (90181297)
KAJI Ryuji  Tokushima University, University of Hospital, Professor, 医学部附属病院, 教授 (00214304)
NAGAMINE Takashi  Kyoto University, Faculty of Medicine, Associate Professor, 医学研究科, 助教授 (10231490)
IKEDA Akio  Kyoto University, Faculty of Medicine, Instructor, 医学研究科, 助手 (90212761)
MIMA Tatsuya  Kyoto University, Faculty of Medicine, Instructor, 医学研究科, 助手 (20324618)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥47,600,000 (Direct Cost: ¥47,600,000)
Fiscal Year 2002: ¥22,400,000 (Direct Cost: ¥22,400,000)
Fiscal Year 2001: ¥25,200,000 (Direct Cost: ¥25,200,000)
Keywordselectroencephalography / magnetoencephalography / functional MRI / transcranial magnetic stimulation / pain perception / involuntary movement / supplementary motor area / premotor area / 磁気共鳴画像法 / 遅延反応課題 / 磁気共鳴機能画像法 / コヒーレンス / 陰性運動 / ジストニー
Research Abstract

The purpose of our research project is to investigate the neural network integrating the sensory input from the external world and the motor act in human, by using the non-invasive techniques, such as electroencephalogram (EEG), magnetoencephalogram (MEG), functional MRI and transcranial magnetic stimulation (TMS). Additionally, when possible and ethically appropriate, we studied the invasive recording in human to advance the research project.
1. Cortical processing of pain perception
By using MEG source analysis, we found the importance of the primary sensory area for the pain perception in human. Our fMRI study showed the top-down control of pain perception is represented in the cingulated and second sensory areas.
2. Cerebral functional depression following the repetitive TMS (r-TMS)
Recently, it was shown that r-TMS can suppress the stimulated brain function transiently (virtual lesion study). By applying this new technique, we found the r-TMS over the primary sensory motor area can transiently suppress the tactile sensation.
3. Abnormal sensorimotor integration in patients with movement disorders
We found that the cortical mechanism of muscle relaxation is abnormal in patients with hand focal dystonia using fMRI. Clinical application of these new non-invasive neuroimaging technique would be promising.
4. Functional relevance of premotor and supplementary motor areas (PM and SMA) in motor control
By using the subdural recording in intractable epilepsy patients who is the candidate for the surgical treatment, we had the opportunity to record duthe epicortical EEG ring the task. We found that the voluntary movement can transiently increase the coherence between SMA and Ml and that the delayed reaction time task activates the PM and M1 successively.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (128 results)

All 2002 2001 2000 Other

All Journal Article (69 results) Publications (59 results)

  • [Journal Article] Second somatosensory area (Sll) plays a significant role in selective somatosensory attention2002

    • Author(s)
      Fujiwara, N. et al.
    • Journal Title

      Brain Res Cogn Brain Res 14

      Pages: 389-397

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] The role of rostral Brodmann area 6 in mental-operation tasks : an integrative neuroimaging approach2002

    • Author(s)
      Hanakawa, T. et al.
    • Journal Title

      Cereb Cortex 12

      Pages: 1157-1170

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Cortical motor mapping in epilepsy patients : information from subdural electrodes in presurgical evaluation2002

    • Author(s)
      Ikeda, A. et al.
    • Journal Title

      Epilepsia 43

      Pages: 56-60

    • NAID

      10010883635

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] "Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural mapping2002

    • Author(s)
      Ikeda, A. et al.
    • Journal Title

      J Neurol Sci 202

      Pages: 43-52

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS)2002

    • Author(s)
      Kanda, M. et al.
    • Journal Title

      Clin Neurophysiol 113

      Pages: 1013-1024

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp : an fMRI study2002

    • Author(s)
      Oga, T.et al.
    • Journal Title

      Brain 125

      Pages: 895-903

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Comparison of striatal dopamine D2 receptors in Parkinson's diseaseand progressive supranuclear palsy patients using [123I] iodobenzofuran single-photon emission computed tomography2002

    • Author(s)
      Oyanagi, C. et al.
    • Journal Title

      J Neuroimaging 12

      Pages: 316-324

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Partial epilepsy manifesting atonic seizure : report of two cases2002

    • Author(s)
      Satow, T. et al.
    • Journal Title

      Epilepsia 43

      Pages: 1425-1431

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Physiology of negative myoclonus2002

    • Author(s)
      Shibasaki, H.
    • Journal Title

      Adv Neurol 89

      Pages: 103-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Second somatosensory area (SII) plays a significant role in selective somatosensory attention2002

    • Author(s)
      Fujiwara, N., Imai, M., Nagamine, T., Mima, T., Oga, T., Takeshita, K., Toma, K., Shibasaki, H.
    • Journal Title

      Brain Res Cogn Brain Res 14 (3)

      Pages: 389-97

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] The role of rostral Brodmann area 6 in mental-operation tasks : an integrative neuroimaging approach2002

    • Author(s)
      Hanakawa.T., Honda, M., Sawamoto, N., Okada, T., Yonekura, Y., Fukuyama, H., Shibasaki, H.
    • Journal Title

      Cereb Cortex 12 (11)

      Pages: 1157-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Cortical motor mapping in epilepsy patients : information from subdural electrodes in presurgical evaluation2002

    • Author(s)
      Ikeda., A., Miyamoto, S., Shibasaki, H.
    • Journal Title

      Epilepsia 43 Suppl 9

      Pages: 56-60

    • NAID

      10010883635

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] "Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural2002

    • Author(s)
      Ikeda, A., Sato, T., Ohara., S., Matsuhashi, M., Yamamoto, J., Takayama.M., Matsumoto, R., Mikuni, N., Takahashi, J., Miyamoto, S., Taki, W., Hashimoto, N., Shibasaki, H.
    • Journal Title

      J Neurol Sci 202 (1-2)

      Pages: 43-52

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS)2002

    • Author(s)
      Kanda, M., Matsuhashi, M., Sawamoto, N., Oga, Mima, T., Nagamine, T., Shibasaki, H.
    • Journal Title

      Clin. Neurophysiol 113 (7)

      Pages: 1013-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp : an fMRI study2002

    • Author(s)
      Oga, T., Honda, M., Toma, K., Murase, N., Okada, T., Hanakawa, T., Sawamoto, N., Nagamine, T., Konishi, J., Fukuyama, H., Kaji, R., Shibasaki, H.
    • Journal Title

      Brain 125 (Pt 4)

      Pages: 895-903

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Comparison. of striatal dopamine D2 receptors in Parkinson's disease and progressive supranuclear palsy patients using [1231] lodobenzofuran single-photon emission computed tomography2002

    • Author(s)
      Oyanagi, C., Katsumi, Y., Hanakawa, T., Hayashi., T., Thuy, D.D., Hashikawa, K., Nagahama, Y., Fukuyama, H., Shibasaki, H.
    • Journal Title

      J Neuroimaging 12 (4)

      Pages: 316-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Partial epilepsy manifesting atonic seizure : report of two cases2002

    • Author(s)
      Satow, T., Ikeda, A., Yamamoto, J., Takayama, M., Matsuhashi, M., Ohara, S., Matsumoto, R., Begum, T., Fukuyama, H., Hashimoto, N., Shibasaki, H.
    • Journal Title

      Epilepsia 43 (11)

      Pages: 1425-31

    • NAID

      10010879895

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Functional mapping of human medial frontal motor areas. The combined use of functional magnetic resonance imaging and cortical stimulation2001

    • Author(s)
      Hanakawa, T. et al.
    • Journal Title

      Exp Brain Res 138

      Pages: 403-409

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Asymmetric tonic seizures with bilateral parietal lesions resembling frontal lobe epilepsy2001

    • Author(s)
      Ikeda, A. et al.
    • Journal Title

      Epileptic Disord 3

      Pages: 17-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Dissociable mechanisms of attentional control within the human prefrontal cortex2001

    • Author(s)
      Nagahama, Y. et al.
    • Journal Title

      Cereb Cortex 11

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor areas during voluntary movements2001

    • Author(s)
      Ohara, S. et al.
    • Journal Title

      J Neurosci 21

      Pages: 9377-9386

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Functional mapping of human medial frontal motor areas. The combined use of functional magnetic resonance2001

    • Author(s)
      Hanakawa, T., Ikeda, A., Sadato, N., Okada, T., Fukuyama, H., Nagamine, T., Honda, M., Sawamoto, N., Yazawa, S., Kunieda, T., Ohara., S., Taki, W., Hashimoto, N., Yonekura, Y., Konishi, J., Shibasaki, H.
    • Journal Title

      Exp Brain Res 138 (4)

      Pages: 403-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Asymmetric tonic seizures with bilateral parietal lesions resembling frontal lobe epilepsy2001

    • Author(s)
      Ikeda., A., Matsumoto, R., Ohara, S., Kunieda, T., Shirakashi, Y., Kaji, R., Fukuyama, H., Shibasaki, H.
    • Journal Title

      Epileptic Disord 3 (1)

      Pages: 17-22

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Dissociable mechanisms of attentional control within the human prefrontal cortex2001

    • Author(s)
      Nagahama, Y., Okada, T., Katsumi, Y., Hayashi, T., Yamauchi, H., Oyanagi, C., Konishi, J., Fukuyama, H., Shibasaki, H.
    • Journal Title

      Cereb Cortex 11 (1)

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor2001

    • Author(s)
      Ohara, S., Mima, T., Baba, K., Ikeda, A., Kunieda., T., Matsumoto, R., Yamamoto, J., Matsuhashi, M., Nagamine, T., Hirasawa, K., Hori, T., Mihara, T., Hashimoto, N., Salenius, S., Shibasaki, H.
    • Journal Title

      Neurosci 21 (23)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Essential role of the right superior parietal cortex in Japanese kana mirror reading : An fMRI study2000

    • Author(s)
      Dong, Y. et al.
    • Journal Title

      Brain 123

      Pages: 790-799

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Carotid brainstem reflex myoclonus after hypoxic brain damage2000

    • Author(s)
      Hanakawa, T. et al.
    • Journal Title

      J Neurol Neurosurg Psychiatry 69

      Pages: 672-674

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Role of primary sensorimotor cortices in generating inhibitory motor response in humans2000

    • Author(s)
      Ikeda, A. et al.
    • Journal Title

      Brain 123

      Pages: 1710-1721

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Autosomal dominant temporal lobe epilepsy in a Japanese family2000

    • Author(s)
      Ikeda, A. et al.
    • Journal Title

      J Neurol Sci 176

      Pages: 162-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Activity-dependent conduction block in multifocal motor neuropathy2000

    • Author(s)
      Kaji, R. et al.
    • Journal Title

      Brain 123

      Pages: 1602-1611

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Primary somatosensory cortex is actively involved in pain processing in human2000

    • Author(s)
      Kanda, M. et al.
    • Journal Title

      Brain Res 853

      Pages: 282-289

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Glucose metabolism in the rat frontal cortex recovered without the recovery ofcholine acetyltransferase activity after lesioning of the nucleus basalis magnocellularis2000

    • Author(s)
      Katsumi, Y. et al.
    • Journal Title

      Neurosci Lett 280

      Pages: 9-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Different activation of presupplementary motor area, supplementary motor area proper, and primary sensorimotor area, depending on the movement repetition rate in humans2000

    • Author(s)
      Kunieda, T. et al.
    • Journal Title

      Exp Brain Res 135

      Pages: 163-172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Use of cavernous sinus EEG in the detection of seizure onset andspread in mesial temporal lobe epilepsy2000

    • Author(s)
      Kunieda, T. et al.
    • Journal Title

      Epilepsia 41

      Pages: 1411-1419

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Vascular cell components of the medullary arteries in Binswanger's disease brains : a morphometric and Immunoelectron microscopic study2000

    • Author(s)
      Lin, J.X.etal.
    • Journal Title

      Stroke 31

      Pages: 1838-1842

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Nonconvulsive focal inhibitory seizure : subdural recording from motor cortex2000

    • Author(s)
      Matsumoto, R. et al.
    • Journal Title

      Neurology 55

      Pages: 429-431

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Nicotine-sensitive writer's cramp2000

    • Author(s)
      Murase, N. et al.
    • Journal Title

      Mov Disord 15

      Pages: 1276-1279

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Abnormal premovement gating of somatosensory input in writer'scramp2000

    • Author(s)
      Murase, N. et al.
    • Journal Title

      Brain 123

      Pages: 1813-1829

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Attentional modulation of parieto-occipital cortical responses : implications for hemispatial neglect2000

    • Author(s)
      Nakamura, K. et al.
    • Journal Title

      J Neurol Sci 176

      Pages: 136-143

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Implication of sensorimotor integration in the generation of periodic dystonic myoclonus in subacute sclerosing panencephalitis (SSPE)2000

    • Author(s)
      Oga, T.et al.
    • Journal Title

      Mov Disord 15

      Pages: 1173-1183

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Electrocorticogram-electromyogram coherence during isometric contraction of hand muscle in human2000

    • Author(s)
      Ohara, S. et al.
    • Journal Title

      Clin Neurophysiol 111

      Pages: 2014-2024

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Movement-related change of electrocorticographic activity in human supplementary motor area proper2000

    • Author(s)
      Ohara, S. et al.
    • Journal Title

      Brain 123

      Pages: 1203-1215

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Expectation of pain enhances responses to nonpainful somatosensory stimulationin the anterior cingulate cortex and parietal operculum/posterior insula : an event-related functional magnetic resonance imaging study2000

    • Author(s)
      Sawamoto, N. et al.
    • Journal Title

      J Neurosci 20

      Pages: 7438-7445

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Electrophysiological studies of myoclonus2000

    • Author(s)
      Shibasaki, H.
    • Journal Title

      Muscle Nerve 23

      Pages: 321-335

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Desynchronization and synchronization of central 20-Hz rhythms associated with voluntary muscle relaxation : a magnetoencephalographic study2000

    • Author(s)
      Toma, K. et al.
    • Journal Title

      Exp Brain Res 134

      Pages: 417-425

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Human presupplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medialfrontal cortex2000

    • Author(s)
      Yazawa, S. et al.
    • Journal Title

      Exp Brain Res 131

      Pages: 165-177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Cortical potentials associated with voluntary mandibular movements2000

    • Author(s)
      Yoshida, K. et al.
    • Journal Title

      J Dent Res 79

      Pages: 1514-1518

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Essential role of the right superior parietal cortex in Japanese kana mirror reading : An fMRI study2000

    • Author(s)
      Dong, Y., Fukuyama, H., Honda, M., Okada, T., Hanakawa, T., Nakamura, K., Nagahama, Y., Nagamine, T., Konishi, J., Shibasaki, H.
    • Journal Title

      Brain 123 ( Pt 4)

      Pages: 790-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Carotid brainstem reflex myoclonus after hypoxic brain damage2000

    • Author(s)
      Hanakawa, T., Hashimoto, S., Iga, K., Segawa, Y., Shibasaki, H.
    • Journal Title

      J Neurol Neurosurg Psychiatry 69 (5)

      Pages: 672-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Role of primary sensorimotor cortices in generating inhibitory motor response in humans2000

    • Author(s)
      Ikeda, A., Ohara, S., Matsumoto, R., Kunieda, T., Nagamine, T., Miyamoto, S., Kohara, N., Taki, W., Hashimoto, N., Shibasaki, H.
    • Journal Title

      Brain 123 ( Pt 8)

      Pages: 1710-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Autosomal dominant temporal lobe epilepsy in a Japanese family2000

    • Author(s)
      Ikeda, A., Kunieda, T., Miyamoto, S., Fukuyama, H., Shibasaki., H.
    • Journal Title

      Neurol Sci 176 (2)

      Pages: 162-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Activity-dependent conduction block in multifocal motor neuropathy2000

    • Author(s)
      Kaji, R., Bostock, H., Kohara, N., Murase, N., Kimura, J., Shibasaki, H.
    • Journal Title

      Brain 123 ( Pt 8)

      Pages: 1602-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Primary somatosensory cortex is actively involved in pain processing in human2000

    • Author(s)
      Kanda, M., Nagamine, T., Ikeda, A., Ohara, S., Kunieda, T., Fujiwara, N., Yazawa, S., Sawamoto, N., Matsumoto, R., Taki.W., Shibasaki, H.
    • Journal Title

      Brain Res 853 (2)

      Pages: 282-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Glucose metabolism in the rat frontal cortex recovered without the recovery of choline acetyltransferase activity after lesioning of the nucleus basalis magnocellularis2000

    • Author(s)
      Katsumi, Y., Hayashi, T., Oyanagi, C., Nagahama, Y., Yamauchi, H., Ono, S., Fukuyama, H., Shibasaki, H.
    • Journal Title

      Neurosci Lett 230 (1)

      Pages: 9-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Different activation of presupplementary motor area, supplementary motor area proper, and primary sensorimotor area, depending on the movement repetition rate in humans2000

    • Author(s)
      Kunieda, T., Ikeda, A., Ohara, S., Yazawa., S., Nagamine, T., Taki, W., Hashimoto, N., Shibasaki, H.
    • Journal Title

      Exp Brain Res 135 (2)

      Pages: 163-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Use of cavernous sinus EEG in the detection of seizure onset and spread in mesial temporal lobe epilepsy2000

    • Author(s)
      Kunieda, T., Ikeda, A., Mikuni, N., Ohara, S., Sadato, A., Taki, W., Hashimoto, N., Shibasaki, H.
    • Journal Title

      Epilepsia 41. (11)

      Pages: 1411-9

    • NAID

      10010907820

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Vascular cell components of the medullary arteries in Binswanger's disease brains : a morphometric and immunoelectron microscopic study2000

    • Author(s)
      Lin, J.X., Tomimoto, H., Akiguchi, I., Matsuo, A., Wakita, H., Shibasaki, H., Budka, H.
    • Journal Title

      Stroke 31 (8)

      Pages: 1838-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Nonconvulsive focal inhibitory seizure : subdural recording from motor cortex2000

    • Author(s)
      Matsumoto, R., Ikeda., A., Ohara, S., Kunieda, T., Kimura, K., Takahashi, J.B., Miyamoto, S., Taki, W., Hashimoto, N., Shibasaki, H.
    • Journal Title

      Neurology 55 (3)

      Pages: 429-31

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Nicotine-sensitive writer's cramp2000

    • Author(s)
      Murase, N., Kaji, R., Sakamoto, T., Shimazu, H., Matumoto, S., Kohar, N., Shibasaki, H., Kimura, J.
    • Journal Title

      Mov Disord 15 (6)

      Pages: 1276-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Abnormal premovement gating of somatosensory input in writer's cramp2000

    • Author(s)
      Murase, N., Kaji, R., Shimazu, H., Katayama-Hirota, M., Ikeda, A., Kohara, N., Kimura, J., Shibasaki, H., Rothwell, J.C.
    • Journal Title

      Brain 123 ( Pt 9)

      Pages: 1813-29

    • NAID

      10008489826

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Attentional modulation of parieto-occipital cortical responses : implications for hemispatial neglect2000

    • Author(s)
      Nakamura, K., Honda, M., Okada, T., Hankawa, T., Fukuyama, H., Konishi, J., Shibasaki, H.
    • Journal Title

      J Neurol Sci 1.76 (2)

      Pages: 136-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Implication of sensorimotor integration in the generation of periodic dystonic myoclonus in subacute sclerosing panencephalitis (SSPE)2000

    • Author(s)
      Oga, T., Ikeda, A., Nagamine, T., Sumi, E., Matsumoto, R., Akiguchi, l., Kimura, J., Shibasaki, H.
    • Journal Title

      Mov Disord 15 (6)

      Pages: 1173-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Electrocorticogram-electromyogram coherence during isometric contraction of hand muscle in human2000

    • Author(s)
      Ohara, S., Nagamine.T., Ikeda, A., Kunieda, T..Matsumoto, R., Taki, W., Hashimoto.N., Baba, K., Mihara., T., Salenius, S., Shibasaki, H.
    • Journal Title

      Clin Neurophysiol 111 (11)

      Pages: 2014-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Movement-related change of electrocorticographic activity in human supplementary motor area proper2000

    • Author(s)
      Ohara, S., Ikeda, A., Kunieda, T., Yazawa, S., Baba, K., Nagamine, T., Taki, W., Hashimoto, N., Mihara, T., Shibasaki, H.
    • Journal Title

      Brain 123 ( Pt 6)

      Pages: 1203-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula : an event-related functional magnetic resonance imaging study2000

    • Author(s)
      Sawamoto, N., Honda, M., Okada, T., Hanakawa, T., Kanda, M., Fukuyama, H., Konishi, J., Shibasaki, H.
    • Journal Title

      J Neurosci 20(19)

      Pages: 7438-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Electrophysiological studies of myoclonus2000

    • Author(s)
      Shibasaki, H.
    • Journal Title

      Muscle Nerve 23 (3)

      Pages: 321-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Desynchronization. and synchronization of central 20-Hz rhythms associated with voluntary muscle relaxation: a magnetoencephalographic study2000

    • Author(s)
      Toma, K., Nagamine, T., -Yazawa, S., Terada., K., Ikeda, A., Honda, M., Oga, T., Shibasaki, H.
    • Journal Title

      Exp Brain Res 134(4)

      Pages: 417-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Human presupplementary motor area. Is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex2000

    • Author(s)
      Yazawa, S., Ikeda, A., Kunieda, T., Ohara, S., Mima, T., Nagamine, T., Taki, W., Kimura, J., Hori, T., Shibasaki, H.
    • Journal Title

      Exp Brain Res 131(2)

      Pages: 165-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Cortical potentials associated with voluntary mandibular movements2000

    • Author(s)
      Yoshida, K., Kali, R., Hamano, T., Kohara, N., Kimura., J., Shibasaki, H., Ilzuka, T.
    • Journal Title

      J Dent Res 79(7)

      Pages: 1514-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kanda M. et al.: "Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS)"Clin Neurophysiol. 113. 1013-1024 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sawamoto N. et al.: "Cognitive slowing in Parkinson's disease : a behavioral evaluation independent of motor slowing J Neurosci"J Neurosci. 15. 5198-5203 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamamoto J, et al.: "Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy"Epiolepsia. 43. 491-495 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shibasaki H: "Physiology of negative myoclonus"Adv Neurol. 89. 101-113 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oga T, et al.: "Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp : an fMRI study"Brain. 125. 895-903 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakamura K, et al.: "Modulation of the visual word retrieval system in writing : a functional MRI study on the Japanese orthographies"J Cogn Neurosci. 14. 104-115 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Satow T, et al.: "Partial epilepsy manifesting atonic seizure : report of two case"Epilepsia. 43. 1425-1431 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Fujiwara N. et al.: "Second somatosensory area (SII) plays a significant role in selective somatosensory attention"Cognitive Brain Research. 14. 389-397 (2002)

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      2002 Annual Research Report
  • [Publications] Yoshida K. et al.: "Factors influencing the therapeutic effect of muscle afferent block for oromandibular dystonia and dyskinesia : implications for their distinct pathophysiology"Int J Oral Maxillofac Surg. 31. 499-505 (2002)

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      2002 Annual Research Report
  • [Publications] Ikeda A. et al.: "Cortical motor mapping in epilepsy patients : information from subdural electrodes in presurgical evaluation"Epilepsia. 43. 56-60 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Oyanagi C. et al.: "Comparison of striatal dopamine D2 receptors in Parkinson's disease and progressive supranuclear palsy patients using [123l] iodobenzofuran single-photon emission computed tomography"J Neuroimaging. 12. 316-324 (2002)

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      2002 Annual Research Report
  • [Publications] Hanakawa T. et al.: "The role of rostral Brodmann area 6 in mental-operation tasks : an integrative neuroimaging approach"Cereb Cortex. 12. 1157-1170 (2002)

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      2002 Annual Research Report
  • [Publications] Hayashi T. et al.: "Neuronal nitric oxide has a role as a perfusion regulator and a synaptic modulator in cerebellum but not in neocortex during somatosensory stimulation--an animal PET study"Neurosci Res. 44. 155-165 (2002)

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      2002 Annual Research Report
  • [Publications] Ikeda A. et al.: ""Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural mapping"J Neurol Sci. 15. 43-52 (2002)

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      2002 Annual Research Report
  • [Publications] Takeshita K et al.: "Maturational change of parallel auditory processing in school-aged children revealed by simultaneous recording of magnetic and electric cortical resronses"Clin Neurophysiol. 113. 1470-1484 (2002)

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      2002 Annual Research Report
  • [Publications] Yamamoto J et al.: "Seizures arising from the inferior parietal lobule can show ictal semiology of the second sensory seizure (SII seizure)"J Neurol Neurosurg Psychiatry. 74. 367-369 (2002)

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      2002 Annual Research Report
  • [Publications] Satow, T. et al.: "Nausea as a complication of low-frequency repetitive transcranial magnetic stimulation of the posterior fossa"Clin Neurophysiol. 113. 1441-1443 (2002)

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      2002 Annual Research Report
  • [Publications] Kanda M, et al.: "Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS)"Clin Neurophysiol. 113. 1013-1024 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Usui K et al.: "Conversion of semantic information into phonological representation : a function in left posterior basal temporal area"Brain. 126. 632-641 (2003)

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      2002 Annual Research Report
  • [Publications] Yoshida K et al.: "Movement-related cortical potentials before jaw excursions in oromandibular dystonia"Mov Disord. 18. 94-100 (2003)

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      2002 Annual Research Report
  • [Publications] Satow T, et al.: "Short-lasting impairment of tactile perception after low-frequency rTMS of the sensorimotor cortex"Neurology. 60. 1045-1047 (2003)

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      2002 Annual Research Report
  • [Publications] Hanakawa T. et al.: "Functional properties of brain areas associated with motor execution and imagery"J Neurophysiol. 89. 989-1002 (2003)

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      2002 Annual Research Report
  • [Publications] Kanda M. et al.: "Transcranial magnetic stimulation (TMS) of the sensorimotor cortex and medial frontal cortex modifies human pain perception"Clin Neurophysiol. (In press).

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      2002 Annual Research Report
  • [Publications] Ikeda A et al.: "Motor inhibition by human supplementary motor area proper"Clin Neurophysiol. (In press).

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      2002 Annual Research Report
  • [Publications] Ikeda A, et al.: "Motor inhibition by human supplementary motor area proper"Clin Neurophysiol. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamoto J, et al.: "Low frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy"Epilepsia. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Satow T, et al.: "Partial epilepsy manifesting atonic seizure: report of two case"Epilepsia. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Fujiwara N, et al.: "Second somatosensory area (SII) plays a significant role in selective somatosensory attention"Cogn. Brain Res.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Oga T, et al.: "Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp : an fMRI study"Brain. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakamura K, et al.: "Modulation of the visual word retrieval system in writing : a functional MRI study on the Japanese orthographies"J Cogn Neurosci.. 14. 104-115 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohara S, et al.: "Increased synchronization of cortical oscillatory activities between human supplementary motor and primary sensorimotor areas during voluntary movements"J Neurosci.. 21. 9377-9386 (2001)

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      2001 Annual Research Report
  • [Publications] Bai O, et al.: "Accurate identification of waveform of evoked potentials by component decomposition using discrete cosine transform modeling"Med Eng Phys.. 23. 615-622 (2001)

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      2001 Annual Research Report
  • [Publications] Bai O, et al.: "Compensation of hand movement for patients by assistant force : relationship between human hand movement and robot arm motion"IEEE Trans Neural Syst Rehabil Eng.. 9. 302-307 (2001)

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      2001 Annual Research Report
  • [Publications] Bai O, et al.: "Markov Process Amplitude EEG Model for Spontaneous Background Activity"J Clin Neurophysiol.. 18. 238-290 (2001)

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      2001 Annual Research Report
  • [Publications] Bai O, et al.: "Parametric modeling of somatosensory evoked potentials using discrete cosine transform"IEEE Trans Biomed Eng.. 48. 1347-1351 (2001)

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      2001 Annual Research Report
  • [Publications] Hanakawa T, et al.: "Functional mapping of human medial frontal motor areas. The combined use of functional magnetic resonance imaging and cortical stimulation"Exp Brain Res.. 138. 403-409 (2001)

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      2001 Annual Research Report
  • [Publications] Ikeda A, et al.: "Asymmetric tonic seizures with bilateral parietal lesions resembling frontal lobe epilepsy"Epileptic Disord.. 3. 17-21 (2001)

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      2001 Annual Research Report
  • [Publications] Matsumoto S, et al.: "DYT1 mutation in Japanese patients with primary torsion dystonia"Neuroreport.. 26. 793-795 (2001)

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      2001 Annual Research Report
  • [Publications] Nagahama Y: "Dissociable mechanisms of attentional control within the human prefrontal cortex"Cereb Cortex.. 11. 85-92 (2001)

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      2001 Annual Research Report
  • [Publications] Dong,Y.: "Essential role of the right superior parietal cortex in Japanese kana mirror reading : An fMRI study."Brain. 123. 790-9 (2000)

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      2000 Annual Research Report
  • [Publications] Ikeda,A.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans."Brain. 123. 1710-21 (2000)

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      2000 Annual Research Report
  • [Publications] Kanda,M.: "Primary somatosensory cortex is actively involved in pain processing in human."Brain Res. 853. 282-9 (2000)

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  • [Publications] Katsumi,Y: "Glucose metabolism in the rat frontal cortex recovered without the recovery of choline acetyltransferase activity after lesioning of the nucleus basalis magnocellularis."Neurosci Lett. 280. 9-12 (2000)

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  • [Publications] Kunieda,T.: "Different activation of presupplementary motor area, supplementary motor area proper, and primary sensorimotor area, dependir, on the movement repetition rate in humans."Exp Brain Res. 135. 163-72 (2000)

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      2000 Annual Research Report
  • [Publications] Murase,N.: "Abnormal premovement gating of somatosensory input in writer's cramp."Brain. 123. 1813-29 (2000)

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      2000 Annual Research Report
  • [Publications] Naito,Y.: "Increased cortical activation during hearing of speech in cochlear implant users."Hear Res. 143. 139-46 (2000)

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  • [Publications] Nakamura,K.: "Participation of the left posterior inferior temporal cortex in writing and mental recall of kanji orthography : A functional MRI study."Brain. 123. 954-67 (2000)

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      2000 Annual Research Report
  • [Publications] Nakamura,K.: "Attentional modulation of parieto-occipital cortical responses : implications for hemispatial neglect."J Neurol Sci,. 176. 136-43 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Oga,T.: "Implication of sensorimotor integration in the generation of periodic dystonic myoclonus in subacute sclerosing panencephalitis (SSPE)."Mov Disord. 15. 1173-83 (2000)

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      2000 Annual Research Report
  • [Publications] Ohara,S.: "Movement-related change of electrocorticographic activity in human supplementary motor area proper."Brain. 123. 1203-15 (2000)

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      2000 Annual Research Report
  • [Publications] Ohara,S.: "Electrocorticogram-electromyogram coherence during isometric contraction of hand muscle in human."Clin Neurophysiol. 111. 2014-24 (2000)

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      2000 Annual Research Report
  • [Publications] Oohashi,T.: "Inaudible high-frequency sounds affect brain activity : hypersonic effect."J Neurophysiol. 83. 3548-58 (2000)

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      2000 Annual Research Report
  • [Publications] Sawamoto,N.: "Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal Operculum/Posterior insula : an event-related functional magnetic resonance imaging stuyd."J Neurosci. 20. 7438-45 (2000)

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      2000 Annual Research Report
  • [Publications] Shimazu,H.: "High-frequency SEP components generated in the somatosensory cortex of the monkey."Neuroreport. 11. 2821-6 (2000)

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      2000 Annual Research Report
  • [Publications] Toma,K.: "Desynchronization and synchronization of central 20-Hz rhythms associated with voluntary muscle relaxation : a magnetoencephalographic study."Exp Brain Res. 134. 165-77 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yazawa,S.: "Human presupplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex."Exp Brain Res. 131. 165-77 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yoshida,K.: "Cortical potentials associated with voluntary mandibular movements."J Dent Res. 79. 1514-8 (2000)

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      2000 Annual Research Report
  • [Publications] Nagahama,Y.: "Dissociable Mechanisms of Attentional Control within the Human Prefrontal Cortex."Cereb Cortex. 11. 85-92 (2001)

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      2000 Annual Research Report
  • [Publications] Hanakawa T.: "Presurgical functional mapping of medial frontal motor areas : a combined use of functional MRI and subdural recording."Exp Brain Res. (予定). (2000)

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      2000 Annual Research Report

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Published: 2001-04-01   Modified: 2018-03-28  

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