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造血幹細胞の増殖・分化とその異常に関する研究

Research Project

Project/Area Number 12215067
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

中畑 龍俊  京都大学, 医学研究科, 教授 (20110744)

Co-Investigator(Kenkyū-buntansha) 依藤 亨 (依藤 享)  京都大学, 医学研究科, 講師 (60220779)
足立 壮一  京都大学, 医学研究科, 講師 (10273450)
林 英蔚  京都大学, 医学研究科, 助手 (40283600)
Project Period (FY) 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥65,500,000 (Direct Cost: ¥65,500,000)
Fiscal Year 2004: ¥14,500,000 (Direct Cost: ¥14,500,000)
Fiscal Year 2003: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2002: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2001: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2000: ¥12,000,000 (Direct Cost: ¥12,000,000)
Keywords白血球 / サイトカイン / 造血幹細胞 / G-CSFR / hemangioblast / Kostmann症候群 / ES細胞 / トランスジェニックマウス / 白血病 / 発生 / 分化 / 遺伝子クローン / EPOR- / -マウス / GM-CSFR / 遺伝子クローニング / CD34 / AGM領域 / G-CSF受容体
Research Abstract

造血幹細胞の発生、性状、増殖・分化機構とその異常、サイトカイン受容体の異常と白血病発症との因果関係、白血病発症の分子機構が明らかにすることを目的に研究を行い以下の成果が得られた。
(1)ヒト造血幹細胞を容易に受け入れるNOD/SCID/γ_c^<-/->(NOG)マウスを開発した。このマウスに移植したヒト臍帯血CD34+細胞からサイトカインの投与なしに顆粒球、赤芽球、マクロファージ、巨核球、血小板、T, B, NK, NKT, DC,肥満細胞を含む全てのヒト型血球分化が認められた。ヒトT細胞の初期分化は主に胸腺内で行われ、一部胸腺外分化も認められ、血清中にヒト型のIgM, IgG, IgAが観察された。
(2)造血幹細胞増殖支持能を持つストローマ細胞株を樹立した。このストローマ細胞株上でサルES細胞を培養すると非常に多くの血球が出現することから造血幹細胞を生み出すのに必要な分子も発現している可能性が示唆された。
(3)G-CSFR遺伝子異常を持ちKostmann症候群のモデルとなる2種類のTgマウスを作成した。変異G-CSFR-TgマウスへG-CSFを1年間連日皮下すると、3血球系とも著明に増加した状態が続いたが、白血病の発生は見られなかった。
(4)サルES細胞から胎児型の血液細胞と成体型の血液細胞の両者および血管内皮細胞を誘導することが可能となった。サルでもマウスと同様、血液と血管内皮の共通の母細胞であるhemangioblastの存在が明らかとなった。

Report

(5 results)
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (202 results)

All 2005 2004 Other

All Journal Article (42 results) Book (2 results) Publications (158 results)

  • [Journal Article] limited ability of antigen-specific Th1 responses to inhibit Th2 cell development in vivo.2005

    • Author(s)
      Yasumi T, Katamura K., Okafuji I., Yoshioka T., Meguro T., Nishikomori R., Kusunoki T., Heike T., Nakahata T.
    • Journal Title

      J.Immunol. 177

      Pages: 1325-1331

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Early-onset sarcoidosis and CARD15 mutations : common genetic etiology with Blau syndrome.2005

    • Author(s)
      Kanazawa N., Nishikomori R., Kambe N., Nakata-Hizume M., Okafuji I., Nagai S., Fuji A., Yuasa T., Utani A., Manki A.Sakurai Y., Nakajima M., Kobayashi H., Nrshigori C., Heike T., Nakahata T., Miyachi Y.
    • Journal Title

      Blood 105

      Pages: 1195-1197

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel NF-kB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutivety activated c-kit receptors.2005

    • Author(s)
      Tanaka A., Konno M., Muto S., Kambe N., Morii E., Nakahata T., Itai A., Matsuda H.
    • Journal Title

      Blood 105

      Pages: 2324-2331

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Stem cell factor has a suppressive activity to IgE-mediated chem.otaxis of mast cells.2005

    • Author(s)
      Sawada J., Shimizu S., Tamatani T., Kanagasaki S., Saito H., Tanaka A., Kambe N., Nakahata T., Matsuda H.
    • Journal Title

      J.Immunol. 174

      Pages: 3626-3632

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Inhibition of leukemiac cell growth by a novel anti-cancer drug (GUT-70) from calophylim brasiilense that acts by induction of apoptosiss.2005

    • Author(s)
      Kimura S., Ito C., Jyoko N., Segawa H.Kuroda J., Okada M., Adachi S., Nakahata T., Yuasa T., Filho VC., Furukawa H., Maekawa T.
    • Journal Title

      Int.J.Cancer 133

      Pages: 158-165

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CpG inhibits IgE clas switch recombination through suppression of NFkB activity, but not through Id2 or Bcl6. Biochem.Biophys.Res.2005

    • Author(s)
      Kusunoki, Sugai M., Gonda H., Nambu Y., Nagata-Nakajima N., Katakai T., Kusunoki M., Sakamoto A., Tokuhisa T., Nakahata T., Yokota Y., Shimizu A.
    • Journal Title

      Commun. 328

      Pages: 499-506

    • Related Report
      2004 Annual Research Report
  • [Journal Article] SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis. J.Allergy Clin.2005

    • Author(s)
      Kusunoki, T., Okafuji I., Yoshioka T., Saito M, Nishikomori R., Heike T., Shimizu A., Nakahata T.
    • Journal Title

      Immunol 115

      Pages: 636-638

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 造血系幹細胞2005

    • Author(s)
      中畑龍俊
    • Journal Title

      ティッシュエンジニアリング2005 1(2)

      Pages: 11-17

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of primitive and definitive hematopoiesis from nonhuman primate embryonic stem cells in vitro.2004

    • Author(s)
      Umeda K., Heike T., Yoshimoto M., Shiota M., Suemori H., Luo H.Y., Chui D.H.K., Shibuya M., Nakatsuji N., Nakahata T.
    • Journal Title

      Development 131

      Pages: 1869-1879

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body.2004

    • Author(s)
      Kambe N.hiramatsu H., SnimonaKa M., Fujino H., Nishikomori R., Heike T.Ito M., kobayashi K., Ueyama Y., Matsuyoshi N., Miyachi Y., Nakahata T.
    • Journal Title

      Blood 103

      Pages: 860-867

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy2004

    • Author(s)
      Matsubara H, Watanabe K, Sakai H, Chang H, Fujino H, Higashi Y, Kobayashi M, Adachi S, Seto S, Nakahata T
    • Journal Title

      Spine 29

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Apoptosis induced by molecular targeting therapy in hematological malignancies.2004

    • Author(s)
      Adachi S., Leoni M., Carson DA, Nakahata T.
    • Journal Title

      Acta Haematol 111

      Pages: 107-123

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Differential Requirement of the Cd40-CD154 costimulatory pathway during Th cell priming by CD8a+ and CD8a- murine dendritic cell subsets.2004

    • Author(s)
      Yagasaki H., Oda T., Adachi D., Nakajima T., Nakahata T., Asano S., Yamashita T.
    • Journal Title

      J.Immunol 172

      Pages: 4826-4833

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Early initiation of GH theraoy does not infuluence adult height but earlier start of pubertal induction in children with multiple pituitary hormone deficiency.2004

    • Author(s)
      Kawai N., Momoi T., Mamada M., Yorifuji T., Nakahata T.
    • Journal Title

      Clin.Endocrinology 60

      Pages: 608-612

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL positive human leukemic cells - caspase-independent, necrosis-like programmed cell death mediated by serine protease activity.2004

    • Author(s)
      Okada M, Adachi S, Imai T, Watanabe K, Toyokuni S, Ueno M, Zervos AS, Kroemer G, Nakahata T.
    • Journal Title

      Blood 103

      Pages: 2299-2397

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Neonatal diabetes mellitus and neonatal polycystic, dysplastic kidneys : phenotypicallydiscordant recurrence of a mutation in the hepatocyte nuclear factor 1b gene due to germ-line mosaicism. J. Clin. Endo.2004

    • Author(s)
      Yorifuji T., Kurokawa K., Mamada M., Imai T., Kawai M., Nishi Y., Shishido S., Hsegawa Y., Nakahata T.
    • Journal Title

      Metab 89

      Pages: 2905-2908

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Living-related liver transplantation for propioric academia. J.Inherit2004

    • Author(s)
      Yorifuji T., Kawai M., Mamada M., Kurokawa K, Egawa H., Shigematsu Y., Kohno Y., Tanaka K., Nakahata T.
    • Journal Title

      Metab.Dis. 27

      Pages: 205-210

    • Related Report
      2004 Annual Research Report
  • [Journal Article] X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival.2004

    • Author(s)
      Nishikomori R., Akutagawa H., Maruyama K., Nakata-Hizume M., Ohmori K., Mizuno K., Yachie A., Yasumi T., Kusunoki T., Heike T., Nakahata T.
    • Journal Title

      Blood 103

      Pages: 4565-4572

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population.2004

    • Author(s)
      Yagasaki H., Hamanoue S, Oda T., Nakahata T., Asano S., Yamashita T.
    • Journal Title

      Human Mutat 24

      Pages: 481-490

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Successful allogeneic bone marrow transplantation in apatient with acute myelogenous leukemia and cytomegalovirus retinitis.2004

    • Author(s)
      Matsubara H., Adachi S., Yano J., Kitamura N., Miyazaki M., Mizushima Y., Hiramatsu H., Kobayashi M., Nakahata T.
    • Journal Title

      Int.J.Hematol. 80

      Pages: 190-192

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Second transplantation from HLA2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation.2004

    • Author(s)
      Tanaka T., Matsubara H., Adachi S., Chang H., Fujino H, Yasumi T.Kobayashi M., Watanabe K, Takahashi M., kobayashi Y., Maruya E., Saji H., Nakahata T.
    • Journal Title

      Int.J.Hematol. 80

      Pages: 467-469

    • NAID

      10014089421

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Viral infections in juvenile myelo-monocytic leukemia : Prevalence and clinical implications.2004

    • Author(s)
      Manabe A., Tsurusawa M., Manabe A., Hayashi Y., Akiyama Y., Kigasawa H., Inada H., Noguchi Y., Sawai N., Kobayashi R., Nagatoshi, Y., Kawakami K., Nakahata T.
    • Journal Title

      J Pediatr Hematol Oncol 26

      Pages: 636-641

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Role of bone marrow-derived progenitor cells in cuff-induced vascular injury in mice.2004

    • Author(s)
      Xu Y., Arai H., Zhuge X., Sano H., Muraya T., Yoshimoto M., Heike T., Nakahata T., Nishikawa S., Kita T., Yokode M.
    • Journal Title

      Arteriosci.Throm.Vas. 24

      Pages: 477-482

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of cardiac stem cells with FLK1 expression during embryonic stem cell differentiation.2004

    • Author(s)
      Iida M., Heike T., Yoshimoto M., Baba S., Doi H., Nakahata T.
    • Journal Title

      FASEB J. 19

      Pages: 371-378

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Generation of multipotent stem cells from postnatal mouse testis.2004

    • Author(s)
      Kanatsu-Shinohara M., Inoue K., Lee J., Yoshimoto M., Ogonuki N., Miki H., Baba T., Kazuki Y., Toyokuni S., Oshimura M., Heike T., Nakahata T., Ishino F., Ogura A., Shinohara T
    • Journal Title

      Cell 119

      Pages: 1001-1012

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Specific recruitment of SPA1 to the immunological synapse : involvement of actin bundling protein actinin.2004

    • Author(s)
      Harazaki M., Kawai Y., Su L., Hamazaki Y., Nakahata T., Minato N., Hattori M.
    • Journal Title

      Immunol.Letter 92

      Pages: 221-226

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 造血幹細胞移植の最近の進歩2004

    • Author(s)
      中畑龍俊
    • Journal Title

      炎症と免疫 12(1)

      Pages: 1-2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 新しいヒト造血幹細胞の測定系2004

    • Author(s)
      平松英文, 中畑龍俊
    • Journal Title

      炎症と免疫 12(1)

      Pages: 11-17

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 硬化性胆管炎から肝硬変に進行し生体肝移植を受けたランゲルハンス細胞組織球症の1例2004

    • Author(s)
      松原央, 渡邊健一郎, 小林道広, 足立壮一, 柴田実, 清益功浩, 橋本尚子, 秋山祐一, 中畑龍
    • Journal Title

      日本小児血液学会雑誌 18

      Pages: 43-46

    • NAID

      10012655058

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 再生医療の現状と問題点2004

    • Author(s)
      中畑龍俊
    • Journal Title

      Inflammation and Regeneration 24(2)

      Pages: 84-91

    • NAID

      130000165334

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 造血幹細胞移植と再生医療2004

    • Author(s)
      中畑龍俊
    • Journal Title

      再生医療 3(1)

      Pages: 33-41

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 再生医療の新たな展開2004

    • Author(s)
      中畑龍俊
    • Journal Title

      分子リウマチ 1(3)

      Pages: 67-72

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 臍帯血移植2004

    • Author(s)
      中畑龍俊
    • Journal Title

      治療学 38(10)

      Pages: 39-43

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cranial aneurysmal bone cystで発症したランゲルハンス細胞組織球症の女児例2004

    • Author(s)
      宮崎真紀, 平松英文, 國貞佳世, 徳舛麻友, 水嶋康浩, 松原央, 小林道弘, 足立壮一, 中畑龍
    • Journal Title

      小児科臨床 57(10)

      Pages: 2147-2152

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 造血幹細胞移植医療とトランスレーショナルリサーチ2004

    • Author(s)
      中畑龍俊
    • Journal Title

      血液フロンティア 14(11)

      Pages: 51-61

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Characterization of mouse hepatic stem/progenytor cells, in a novel culture system.

    • Author(s)
      Tsuchiya A., Heike T., Fujino H., Shiota M., Umeda K., Yoshimoto M., Matsuda Y., Ichida T., Aoyagi Y., Nakahata T.
    • Journal Title

      Gastroenterology (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Two different role of purified Cd45+ hematopoietic stem cells after transplantation in muscles.

    • Author(s)
      Yoshimoto M., Heike T., Shiota M., Kobatashi H., Umeda K., Nakahata T.
    • Journal Title

      Stem Cells (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prospective characterization of neural stem cells by flow cytometry analysis using combination of the surface markers.

    • Author(s)
      Nagato M., Heike T., Kato T., Yamanaka Y., Yoshimoto M., Shimazaki T., Okano H., Nakahata T.
    • Journal Title

      J.Neurosci.Res. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Suplatast tosilate inhibits human mast cell development from cord blood progenitors.

    • Author(s)
      Kambe N., Nakahata T.Miyachi Y.
    • Journal Title

      Allergology International. (In press)

    • NAID

      10015655875

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Therapy-related myelodysplastic syndrome in childhood : A retrospective study of 36 patients in Japan.

    • Author(s)
      Tsurusawa M., Manabe A., Hayashi Y., Akiyama Y., Kigasawa H., Inada H., Noguchi Y., Sawai N., Kobayashi k., Nagatoshi Y., Kawakami K., Nakahata T
    • Journal Title

      Leukemia Res. (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Methylation status of the p15 and p16 genes in paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia.

    • Author(s)
      Hasegawa D., Manabe A., Kubota T., Kawasaki H., Hirose I., Ohtsuka Y., Tsuruta T., Ebihara Y., Goto Y., Yan Zhao X., Sakashita K., Koike K., Isomura M., Kojima S., Hoshika A., Tsuji k., Nakahata T
    • Journal Title

      Brit.J.Haematol (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes.

    • Author(s)
      Kawamura T., Ono K., Morimoto T., Wada H., Hirai M., Hidaka K., Morisaki T., Heike T., Nakahata T., Kita T., Hasegawa K.
    • Journal Title

      J.Biol.Chem. (In press)

    • Related Report
      2004 Annual Research Report
  • [Book] Chapter13「IL-6」サイトカイン・ケモカインのすべて-基礎から最新情報まで-(第三版 改訂新版)2004

    • Author(s)
      吉崎和幸, 石橋敏幸, 中畑龍俊
    • Publisher
      日本医学館
    • Related Report
      2004 Annual Research Report
  • [Book] Chapter57「造血構造とサイトカイン」 サイトカイン・ケモカインのすべて-基礎から最新情報まで-(第三版 改訂新版)2004

    • Author(s)
      中畑龍俊
    • Publisher
      日本医学館
    • Related Report
      2004 Annual Research Report
  • [Publications] Mitsui T., Watanabe S, Nakahata T, et al.: "Impared neutrophil maturation in truncated G-CSF receptor transgenic mice."Blood. 101. 2990-2995 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akizawa, Y., Nishiyama, C., Nakahata T, et al.: "Regulation of human FcepsilonR1 beta chain gene expression by Oct-1."International Immunology. 15. 549-556 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Umeda K., Adachi S, Nakahata T.et al.: "Successful T-cell-replete peripheral blood stem cell transplantation from HLA-haploidentical microchimeric mother to daughter with refractory acute lymphoblastic leukemia using reduced-intensity conditioning."Bone Marrow Transplant.. 31. 1061-1063 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiramatsu H., Nishikomori R., Nakahata T, et al.: "Complete reconstitution of human lymphocytes from cord blood CD34+ cells using NOD/SCID/_<-c>~<null> mice model."Blood. 102. 873-880 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshimoto M., Shinohara T., Heike T, Nakahata, T et al.: "Direct visualization of transplanted hematopoietic cell reconstitution in intact mouse organs indicate the presence of a niche."Hematol.. 31. 733-740 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ishida D., Kometani K., Yang H., Nakahata T., et al.: "Myeloproliferative stem cell disorders by dysregulated Rapl activation in SPA-I-deficient mice."Cancer Cell. 4. 55-65 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Umeda K., Yoshimoto M., Heike T., Nakahata T.: "Development of primitive and definitive hemayopoiesis from nonhuman primate embryonic stem cells in vitro."Development. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Yagasaki H., Oda T., Nakahata T.et al.: "Two common founder mutations of the Fanconi anemia group G gene FANCG/XRCC in the Japanese popuration. Hum."Mutat.. 21. 555(DOI: 10.1002/humu.9142) (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yasumi T, Katamura K.Nakahata T. et al.: "Differential Requirement of the Cd40-CD154 costimulatory pathway during T helper cell priming by CD8_+and CD8_- murine dendritic cell subsets."J.Immunol.. (In press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Okada M., Imai T, Nakahata T.et al.: "A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL positive human leukemic cells - caspase-independent, necrosis-like programmed cell death mediated by serine protease activity."Blood. (in press). (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Xu Y., Arai H., Zhuge X., Nakahata T, et al.: "Role of bone marrow-derived progenitor cells in cuff-induced vascular injury in mice."Arterioscl.Throm.Vas.. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishikomori R., Akutagawa H., Nakahata T.et al.: "X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role For NEMO in human T-cell development and/or survival."Blood. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Lin YW, Watanabe K, Nakahata T, et al.: "Serial Granulocyte transfusions as a treatment for sepsis due to multidrug-resistant pseudomonas aeruginosa in a neutropenic patient."J Clin Microbiol. 41. 4892-4893 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Imai T, Nishijo K, Nakahata T, et al.: "FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells."Oncogene. 22. 9231-9242 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Heike T, Nakahata T.: "Stem cell plasticity in the hematopoietic system."Hematol.. 79. 7-14 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsubara H, Watanabe K, Nakahata T. et al.: "Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy."Spine. 29. E4-E6 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Adachi S., Leoni M., Carson DA, Nakahara T.: "Apoptosis induced by molecular targeting therapy in hematological malignancies."Acta Haematol.. 111. 107-123 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kambe N., Hiramatsu H, Nakahata T, et al.: "Development of both human connective tissue-type and mucosal-type mast cells in mice from hemacopoietic stem cells with identical distribution pattern to human body."Blood. 103. 860-867 (2004)

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      2003 Annual Research Report
  • [Publications] Nishikomori R., Akutagawa H., Nakahata T.et al.: "X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival."Blood. (in press).

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      2003 Annual Research Report
  • [Publications] Harazaki M., Kawai Y., Su L., Hamazaki Y., Nakahata T et al.: "Specific recruitment of SPA1 to the immunological synapse : involvement of actin-bundling protein actinin."Immunol. Letter. (in press).

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      2003 Annual Research Report
  • [Publications] Hiroshi Yagasaki^1, Satoshi Hamanoue^<1, 2>, Nakahata T et al.: "Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population."Human Mutat.. (In press).

    • Related Report
      2003 Annual Research Report
  • [Publications] Yagasaki H., Hamanoue S., Nakahata T et al.: "Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population."Human Mutat.. (In press).

    • Related Report
      2003 Annual Research Report
  • [Publications] 中畑龍俊: "造血幹細胞を用いた再生医療"血夜・免疫・腫瘍. 8(1). 27-32 (2003)

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      2003 Annual Research Report
  • [Publications] 中畑龍俊: "臍帯血利用ex vivo増幅"最新医学. 58. 57-62 (2003)

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      2003 Annual Research Report
  • [Publications] 中畑龍俊: "幹細胞と再生医学"最新医学(2003年3月増刊号). 58. 527-536 (2003)

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      2003 Annual Research Report
  • [Publications] 中畑龍俊: "再生医療の現状と課題"シスメックスジャーナル. 25. 1-9 (2003)

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      2003 Annual Research Report
  • [Publications] 中畑龍俊: "再生医療の現状と課題"細胞工学. 22. 512-515 (2003)

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      2003 Annual Research Report
  • [Publications] 中畑龍俊: "造血幹細胞を用いた再生医療"細胞工学. 22. 516-520 (2003)

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      2003 Annual Research Report
  • [Publications] 平松英文, 平家俊男, 伊藤守, 中畑龍俊: "NOD/SCID/rs nullマウスを用いた新しいヒト造血幹細胞測定系の開発"臨床血液. 44. 193-197 (2003)

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      2003 Annual Research Report
  • [Publications] 平松英文, 中畑龍俊: "NOD/SCID/rs nullマウス"血液・腫瘍科. 47. 46-51 (2003)

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      2003 Annual Research Report
  • [Publications] Manabe A., Nakahata T: "Myelodysplastic and myeloproliferatine disorders in children (eds. Lopes L.F. & Hasle M) Tecmedd,"Experiences on MDS and JMML from Japan.. 317-324 (2003)

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      2003 Annual Research Report
  • [Publications] Ito M, Hiramatsu H, Kobayashi K他: "NOD/SCIDγ^<null>_c mouse : an excellent recipient mouse model for engraftment of human cells"Blood. 100(9). 3175-3185 (2002)

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      2002 Annual Research Report
  • [Publications] Umeda K, Adachi S, Watanabe K他: "Successful hematopoietic stem cell transplantaion for aplastic anemia following living-related liver transplantation"Bone Marrow Transplant. 30. 531-534 (2002)

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      2002 Annual Research Report
  • [Publications] Heike T, Nakahata T.: "Ex vivo expansion of hematopoietic stem cells by cytokines"Biochim Biophys Acta.. 1592. 313-321 (2002)

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      2002 Annual Research Report
  • [Publications] Ebihara Y, Wada M, Ueda T他: "Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34^+CD38^-cells expressing Flk2/FIt3"Brit.J.Haematol.. 119. 525-534 (2002)

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      2002 Annual Research Report
  • [Publications] Kato T, Hattori H, Nagato M他: "Subclinical central pontine myelinolysis following liver transplantation"Brain & Development. 24. 179-182 (2002)

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      2002 Annual Research Report
  • [Publications] Uematsu A, Yorifuji T, Muroi J他: "Parental Origin of Normal X Chromosomes in Turner Syndrome Patients With Various Karyotypes : Implications for the Mechanism Leading to Generation of a 45, X Karyotype"American Journal of Medical Genetics. 111. 134-139 (2002)

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      2002 Annual Research Report
  • [Publications] Katamura K, Hattori H, Kunishima T他: "Non-progressive viral myelitis in X-linked aggammaglobulinemia"Brain Develop.. 24. 109-111 (2002)

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      2002 Annual Research Report
  • [Publications] Nakahata T, Toru H: "Cytokines Regulate Development of Human Mast Cells from Hematopoietic Progenitors"Int, J.Hematol.. 75(4). 350-356 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Iio J, Katamura K, Takeda H他: "Lipid A analogue, ONO-4007, inhibits IgE response and antigen-induced eosinophulic recruitment into airways in BALB/c mice"Int. Arch Allergy Immunol.. 127. 217-225 (2002)

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      2002 Annual Research Report
  • [Publications] Hamahata K, Kubota M, Usami I他: "Somatic cell mutation in pediatric patients undergoing allogeneic bone marrow transplantation"Mutation Research. 517. 21-28 (2002)

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      2002 Annual Research Report
  • [Publications] Kusunoki T, Nakahata T, Miyanomae T他: "Possible dual effect of CD14 molecule on atopy"Am.J.Res.Crit.Care Med. 165. 551-552 (2002)

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      2002 Annual Research Report
  • [Publications] Suzuki N, Ohneda O, Takahashi S他: "Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality"Blood. 100(7). 2279-2288 (2002)

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      2002 Annual Research Report
  • [Publications] Han H, Tanigaki K, Yamamoto N: "Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision"Int.Immunol.. 14. 637-645 (2002)

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      2002 Annual Research Report
  • [Publications] Yorifuji T, Kawai M, Muroi J他: "Unexpectedly high prevalence of the mild form of propionic acidemia in Japan : presence of a common mutation and possible clinical implications"Hum Genet.. 111. 161-165 (2002)

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      2002 Annual Research Report
  • [Publications] Manabe A, Okamura J, Yumura-Yagi K他: "Allogeneic hematopojetic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the Internalional JMML Working Group"Leukemia.. 16. 645-649 (2002)

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      2002 Annual Research Report
  • [Publications] Hiramatsu H, Nishikomori R, Heike T他: "Establishment of functional human immune system in NOD/SCID/γ^<null>_c mice after transplantation of cord blood CD34^+ cells"Blood. (In press).

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      2002 Annual Research Report
  • [Publications] Yoshimoto M, Heike T, Nakahata T.: "Direct visualization of reconstitution process of Transplanted hematopoietic cells in intact mouse organs : Indicative of the presence of a Niche"Exp.Hematol.. (In press).

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      2002 Annual Research Report
  • [Publications] Ishida D, Yang H, Hattori M他: "Dysregulated Rap1 cativation, T-cell anergy, and myeloproliferative disorders of late onset in SPA-1-deficient mice"Cancer Cell. (In press).

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      2002 Annual Research Report
  • [Publications] Yagasaki H, Oda T, Adachi D他: "Two common founder mutations of the Fanconi anemia group G gene FANCG/XRCC in the Japanese popuration"Human Mutat.. (In press).

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      2002 Annual Research Report
  • [Publications] Mitsui T, Watanabe S, Hanada S他: "Impared neutrophil maturation in truncated G-CSF receptor transgenic mice"Blood. (In press).

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      2002 Annual Research Report
  • [Publications] Kusunoki T, Miyanomae T, Inoue Y他: "Lack of correlation between serum levels of soluble CD14 and IgE in asthmatic children"J Allergy Clin Immunol. (In press).

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      2002 Annual Research Report
  • [Publications] Kusunoki T, Sugai M, Katakai T他: "Th2 dominance and defective development of CD8+ dendritic cell subset in Id2-deficient mice"J. Allergy Clin. Immunol.. (In press).

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      2002 Annual Research Report
  • [Publications] 伊藤仁也, 中畑龍俊: "造血幹細胞のex vivo増幅"最新医学. 57(1). 23-30 (2002)

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      2002 Annual Research Report
  • [Publications] 吉本桃子, 中畑龍俊: "Aorta-Gonad-Mesonephros(AGM)領域における造血幹細胞の発生"炎症と免疫. 9(2). 77-82 (2001)

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      2002 Annual Research Report
  • [Publications] 中畑龍俊: "胎児から小児期における造血"血液フロンテイア. 12(2). 33-41 (2002)

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      2002 Annual Research Report
  • [Publications] 平家俊男, 中畑龍俊: "ヒトES細胞"血液・腫瘍科. 44(6). 413-420 (2002)

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  • [Publications] 中畑龍俊: "再生医療の現状と課題"Sysmex Journal Web. 3(1). (2002)

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      2002 Annual Research Report
  • [Publications] 中畑龍俊: "小児のMDSの治療戦略"血液フロンティア. 12(8). 131-138 (2002)

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      2002 Annual Research Report
  • [Publications] 平家俊男, 中畑龍俊: "発生・細胞分化におけるアセチル化"実験医学. 20(15). 2212-2218 (2002)

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      2002 Annual Research Report
  • [Publications] 中畑龍俊: "造血幹細胞の培養増幅とその応用"臨床病理レビュー. 122. 102-109 (2002)

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      2002 Annual Research Report
  • [Publications] 飯田みどり, 平家俊男, 吉本桃子, 他: "マウス胚性幹細胞を用いた心筋細胞分化機構解明の試み"炎症・再生. 22(2). 145-151 (2002)

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      2002 Annual Research Report
  • [Publications] 平松英文, 中畑龍俊(編 高久史磨), 他: "「Annual Review血液2002」NOD/SCID/rc-/-マウスを用いたヒト造血幹細胞の解析"中外医学社. 7 (2001)

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  • [Publications] 中畑龍俊(編 今西二郎, 他): "「別冊・医学のあゆみ 疾病疾患state of arts Ver.2」造血幹細胞移植"医歯薬出版. 5 (2002)

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  • [Publications] 中畑龍俊(編 横田崇): "「再生医学がわかる」造血幹細胞を用いた再生医療"羊土社. 10 (2002)

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  • [Publications] 中畑龍俊(編 小澤敬也): "「造血幹細胞-基礎から遺伝子治療・再生医療へ」造血幹細胞の体外増幅-サイトカイン刺激によるアプローチ"中外医学社. 7 (2002)

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      2002 Annual Research Report
  • [Publications] 中畑龍俊(監 白木和夫 他, 編 伊藤克己, 他): "「小児科学(第2版)」慢性白血病 骨髄異形成症候群"医学書院. 7 (2002)

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      2002 Annual Research Report
  • [Publications] 中畑龍俊(編 室田誠逸): "「再生医学 再生医療(現代化学 増刊41)」幹細胞の分化制御-オーバービュー"東京化学同人. 2 (2002)

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  • [Publications] Nakahata T: "Ex vivo expansion of human hematopoietic stem cells"Int. J. Hematol.. 73(1). 6-13 (2001)

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      2001 Annual Research Report
  • [Publications] Matsuoka S, Ebihara Y, Xu M-j, Ishii T, Sugiyama D, Yoshino H, Ueda T, Manabe A, Tanaka R, Ikeda Y, Nakahata T, Tsuji K: "CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages"Blood. 97. 419-425 (2001)

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      2001 Annual Research Report
  • [Publications] Xu M-j, Matsuoka S, Yang F-C, Ebihara Y, Manabe A, Tanaka R, Eguchi M, Asano S, Nakahata T, Tsuji K: "Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac"Blood. 97. 2016-2022 (2001)

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      2001 Annual Research Report
  • [Publications] Yoshimasu T, Tanaka R, Suenobu S, Yagasaki H, Yoshino H, Ueda T, Hisakawa H, Ishii T, Maekawa T, Nakahata T, Asano S, Tsuji K: "Prompt and durable hematopoietic reconstitution by unrelated cord blood transplantation in a child with Fanconi anemia"Bone Marrow Transplant. 27. 767-769 (2001)

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      2001 Annual Research Report
  • [Publications] Imai T, Hattori H, Miyazaki M, Higuchi Y, Adachi S., Nakahata T: "Dandy-Walker variant in Coffin-Siris syndrome"Am. J. Med. Genet.. 100. 152-155 (2001)

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      2001 Annual Research Report
  • [Publications] Sawano A, Iwai S, Sakurai Y, Ito Y, Shitara K, Nakahata T, Shibuya M: "Flt-1, vascular endothelial growth factor receptor-1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans"Blood. 97. 785-791 (2001)

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      2001 Annual Research Report
  • [Publications] Ma F, Wada M, Yoshino H, Ebhara Y, Ishii T, Manabe A, Tanaka R, Maekawa T, Itoh M, Mugishima H, Asano S, Nakahata T, Tsuji K: "Development of human lymphohematopoietic stem and progenitor cells defined by expression of CD34 and CD81"Blood. 97. 3755-3762 (2001)

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      2001 Annual Research Report
  • [Publications] Ueda T, Yoshida M, Yoshino H, Kobayashi K, Kawahata M, Ebihara Y, Ito M, Asano S, Nakahata T, Tsuji K: "Hematopoietic capability of CD34+ cord blood cells : a comparison with CD34+ adult bone marrow cells"Int. J. Hamatol.. 73. 457-462 (2001)

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      2001 Annual Research Report
  • [Publications] Yamashita T, Nakahata T: "Current knowledge on the pathophysiology of fanconi anemia : from genes to phenotypes"Int. J. Hamatol.. 74. 33-41 (2001)

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      2001 Annual Research Report
  • [Publications] Matsuoka S, Tsuji K, Hisakawa H, Xu M, Ebihara Y, Ishii T, Tanaka R, Ikeda Y, Asano S, Nakahata T: "Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells"Blood. 98. 6-12 (2001)

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      2001 Annual Research Report
  • [Publications] Miyamoto K, Tsuji K, Maekawa T, Asano S, Nakahata T: "Inhibitory effect of interleukin 3 on the early development of human B-lymphopoiesis"Br. J. Haematol. 114. 690-697 (2001)

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      2001 Annual Research Report
  • [Publications] Lin YW, Hamahata K, Watanabe K, Adachi S, Akiyama Y, Kubota M, Nakahata T: "Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnomalities after allogeneic bone marrow transplantation"Int. J. Hematol. 74. 86-89 (2001)

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  • [Publications] Yorifuji T, Muroi J, Mamada M, Uematsu A, Kawai M, Momoi T, Kaji M, Yamanaka C, Nakahata T: "Analysis of the SRY gene in Turner syndrome patients with Y chromosmal material"J. Med. Genet.. 38. e41 (2001)

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      2001 Annual Research Report
  • [Publications] Sasaki H, Manabe A, Kojima S, Tsuchida M, Hayashi Y, Ikuta K, Okamura J, Koike K, Ohara A, Ishii E, Kodama Y, Hibi S, Nakahata T: "Myelodysplastic syndrome in childhood : a retrospective study of 189 patients in Japan"Leukemia. 15. 1713-1720 (2001)

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      2001 Annual Research Report
  • [Publications] Kato T, Hattori H, Yorifuji T, Tashiro Y, Nakahata T: "Intranial aneurysms in Ehlers-Danlos Syndrome type IV in early childhood"Pediatric Neurology. 25(4). 336-339 (2001)

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      2001 Annual Research Report
  • [Publications] Yamanaka Y, Tamari M, Nakahata T, Nakamura Y: "Gene expression profiles of human small airway epithelial cells treated with low doses of 14-and 16-membered macrolides"Biochemical and Biophysical Research Communications. 287. 198-203 (2001)

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      2001 Annual Research Report
  • [Publications] Hisakawa H, Sugiyama D, Nishijima I, Xu M-j, Wu H, N, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K: "Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors"Blood. 98(13). 3618-3625 (2001)

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      2001 Annual Research Report
  • [Publications] Iio J, Katamura K, Takeda H, Ohmura K, Yasumi T, Meguro T, Ohshima Y, Nakahata T: "Lipid A analogue, ONO-4007, inhibits IgE response and antigen-induced eosinophilic recruitment into airways in BALB/c mice"Int. Arch Allergy Immunol.. (In press). (2002)

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      2001 Annual Research Report
  • [Publications] Iwai-Kanai E., Hasegawa K, Sawamura T., Toyokuni S., Adachi S., Kihara Y., Sasayama S.: "Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes"Circulation. 104. 2948-2954 (2001)

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      2001 Annual Research Report
  • [Publications] Iwai-Kanai E., Hasegawa K., Fujita M., Araki M., Yanazume T., Adachi S., Sasayama S.: "Basic fibroblast growth factor protects cardiac myocytes fromiNOS-mediated apoptosis"J Cell Physiol. 190. 54-62 (2002)

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      2001 Annual Research Report
  • [Publications] Kusunoki T., Miyanomae T., Inoue Y., Nakahata T: "Lack of correlation between serum levels of soluble CD14 and IgE in asthmatic children"J Allergy Clin Iminunol. (In press). (2002)

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      2001 Annual Research Report
  • [Publications] Nakahata T, Toru H.: "Cytokines Regulate Development of Human Mast Cells from Hematopoietic Progenitors"Int. J. Hematol.. (In press). (2002)

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      2001 Annual Research Report
  • [Publications] Mitsui T., Watanabe S., Hanada S., Ebihara Y., Sato T., Nakahata T., Tsuji K.: "Impared neutrophil maturation in truncated G-CSF receptor transgenic mice"Blood. (In press). (2002)

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      2001 Annual Research Report
  • [Publications] Hamahata K., Kubota M., Usami I., Lin Y.W., Shimizu K., Morimito A., Nakahata T.: "Somatic cell mutation in pediatric patients undergoing allogeneic bone marrow transplantation"Mutation Research. (In press). (2002)

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      2001 Annual Research Report
  • [Publications] 林英蔚, 渡邉健一郎, 濱畑啓吾, 足立壮一, 秋山祐一, 宇佐美郁哉, 久保田優, 筒井孟, 片岡昭浩, 若園吉裕, 中畑龍俊: "小児t(8;21)急性骨髄性白血病:臨床的特徴と予後因子における成人例との比較"臨床血液. 42(1). 8-14 (2001)

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      2001 Annual Research Report
  • [Publications] 中畑龍俊: "同種末梢血幹細胞移植のための健常人ドナーからの末梢血幹細胞の動員・採取に関するガイドライン"分子細胞治療. 2(1). 69-74 (2001)

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  • [Publications] 中畑龍俊: "NOD/SCIDマウス"分子細胞治療. 2(2). 106-108 (2001)

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      2001 Annual Research Report
  • [Publications] 服部春生, 加藤竹雌, 長門雅子, 岡野智恵, 鈴木元, 名和行文, 中畑龍俊: "沖縄旅行後に発症した広東住血線虫症による好酸球性髄膜炎の1例"日本小児科学会雑誌. 105(6). 719-721 (2001)

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  • [Publications] 中畑龍俊, 小島勢二, 土田昌宏, 生田孝一郎, 岡村純, 小池健一, 小原明, 秋山祐一, 林英蔚, 増永敦子: "第1回MDS委員会活動報告(2001.11.6)"日本小児血液学会雑誌. 15. 54-56 (2001)

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  • [Publications] 中畑龍俊: "造血幹細胞ex vivo増幅の現状と将来"臨床血液. 42(6). 441-446 (2001)

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  • [Publications] 谷口義弘, 中畑龍俊: "小児先天性好中球減少症"血液・免疫・腫瘍. 6(3). 83-85 (2001)

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  • [Publications] 河井昌彦, 金沢房子, 今井剛, 中畑龍俊: "未熟児貧血に対するエリスロポエチン治療中に出現した高CPK血症に関する検討"日本産婦人科・新生児血液学会誌. 11(1). 77-78 (2001)

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  • [Publications] 藤田潤, 駿地眞由美, 小杉眞二, 依藤亨, 藤村聡, 富和清隆, 一山智, 中畑龍俊, 福井次矢: "京都大学医学部付属病院遺伝子診療部の紹介・心理職との連携"JIM. 11(6). 554-556 (2001)

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  • [Publications] 平家俊男, 中畑龍俊: "ES細胞を用いた再生医療の構築に向けて"Organ Biology. 8(3). 143-153 (2001)

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  • [Publications] 中畑龍俊: "同種末梢血幹細胞移植のためのガイドライン"遺伝子医学. 5(3). 134-139 (2001)

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  • [Publications] 平家俊男, 中畑龍俊: "幹細胞と自己複製"癌と化学療法. 28. 1049-1056 (2001)

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  • [Publications] 中畑龍俊: "造血幹細胞の可塑性"内科. 88(3). 525-529 (2001)

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  • [Publications] 渡邉健一郎, 中川剛, 杯英蔚, 梅田雄嗣, 足立壮一, 服部春夫, 中畑龍俊: "除脳硬直姿勢をとったIfosfamide脳症の1例"小児がん. 38(1). 52-55 (2001)

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  • [Publications] 梅田雄嗣, 林英蔚, 渡邉健一郎, 足立壮一, 宇佐美郁哉, 秋山祐一, 久保田優, 中畑龍俊: "小児難治性急性リンパ性白血病に対するbusulfan, thiotepa, cyclophosphamideを前処置とした造血幹細胞移植の治療成績"臨床血液. 42(9). 685-690 (2001)

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  • [Publications] 中畑龍俊: "造血系幹細胞と血液疾患"治療学. 35(10). 25-28 (2001)

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  • [Publications] 平松英文, 中畑龍俊: "NOD/SCIDマウスにおけるヒト造血と免疫の再構案"分子細胞治療. 2(5). 9-15 (2001)

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  • [Publications] 久保田優, 濱畑啓悟, 渡邊健一郎, 林英蔚, 宇佐美郁哉, 中畑龍俊: "全身の色素沈着を伴ったビタミンB12欠乏巨赤芽球性貧血の1例"日本小児血液学会雑誌. 15(5). 401-404 (2001)

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      2001 Annual Research Report
  • [Publications] 中畑龍俊: "再生医療の現状と展望-概説"小児科診療. 64(12). 2180-2183 (2001)

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      2001 Annual Research Report
  • [Publications] 中畑龍俊: "造血幹細胞移植"小児科診療. 64(12). 2184-2189 (2001)

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      2001 Annual Research Report
  • [Publications] 足立壮一, 中畑龍俊: "小児患者への対応"日本臨床. 59(12). 2401-2406 (2001)

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      2001 Annual Research Report
  • [Publications] 伊藤仁也, 中畑龍俊: "造血幹細胞のex vivo増幅"最新医学. 57(1). 23-30 (2002)

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      2001 Annual Research Report
  • [Publications] 中畑龍俊: "胎児から小児期における造血"血液フロンテイア. 12(2). 33-41 (2002)

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      2001 Annual Research Report
  • [Publications] 中畑龍俊(編 元吉和夫): "「造血サイトカイン」 サイトカインによる造血幹細胞の増幅 FLk-2, Flt-3リガンド. FLk-2, Flt-3リガンド(fetal liver kinase-2 ; Flk-2), (fms-like tyrosine kinase-3 ligannd ; FL)"メディカルレビュー社. (29) 85-99, 198-210, 444 (2001)

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      2001 Annual Research Report
  • [Publications] 中畑龍俊(編 中内啓光): "「造血幹細胞のいまと医療への展開」 造血幹細胞研究の現状と期待"羊土社. (14) 12-25 (2001)

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  • [Publications] 中畑龍俊(編 上田龍三): "「プラクティカル内科シリーズ11-造血器腫瘍-白血病・悪性リンパ腫・多発性骨髄腫 治癒をめざした診断・治療の実践-」造血幹細胞"南江堂. (7) 184-190 (2001)

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      2001 Annual Research Report
  • [Publications] 中畑龍俊(編 元吉和夫, 浦部晶夫): "「コロニー刺激因子(SCF)の臨床-現状と将来-」 In Vitroでの造血幹細胞の増幅"日本医学館. (9) 93-101 (2001)

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  • [Publications] 融 葉乃/中畑龍俊 (編 黒沢元博): "「肥満細胞の臨床」 ヒト培養肥満細胞に及ぼすIL-4の効果"先端医学社. (9) 550-558 (2001)

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      2001 Annual Research Report
  • [Publications] 平松英文, 中畑龍俊 (編 高久史磨): "「Annual Review 血液 2002」 NOD/SCID/rc-/-マウスを用いたヒト造血幹細胞の解析"中外医学社. (7) 7-13 (2001)

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  • [Publications] Futaki M.,Yamashita T.,Yabe M.,Kato S.,Nakahata T.: "The IVS4+4A-T mutation of the Fanconi Anemia gene FANCC is not associated with severe phenotype in Japanese patients."Blood. 95. 1493-1498 (2000)

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      2000 Annual Research Report
  • [Publications] Sugiyama H.,Nonaka T.,Komoriya K.,Tsuji K.,Nakahata T.: "Peroxisome proliferator-activated receptors negatively regurate mast cell activation"FEBS Letters. 467. 259-262 (2000)

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      2000 Annual Research Report
  • [Publications] Ueda Y,Tsuji K,Yoshino H,Ebihara Y,Yagasaki H,Yasukawa K,Nakahata T: "Expansion of human NOD/SCID-repopulating cells by a combination of stem cell factor, Flk2/Flt3 ligand, thrombopoietin and a complex of interleukin-6 and soluble interleukin-6 receptor"J Clin Invest. 105. 1013-1021 (2000)

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  • [Publications] Hayashi Y.,Honma Y.,Niitsu N.,Tsuji K.,Nakahata T.: "SN-1, a novel leukemic cell line with t(11;16)(q23;p13) : Myeloid characteristics and resistance to retinoids and vitamin D3."Cancer Res.. 60. 1139-1145 (2000)

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  • [Publications] Misawa K.,Nosaka T.,Morita S.,Nakahata T.,Asano S.,Kitamura T.: "A method to identify cDNA based on localization of green fluorescent protein fusion products."Proc.Natl.Acad.Sci.USA. 97. 3062-3066 (2000)

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  • [Publications] Ebihara Y,Xu M,Nakahata T,Tsuji K: "Exclusive expression of G-CSF receptor on myeloid progenitors in bone marrow CD34+ cells"Br J Haematol. 109. 153-161 (2000)

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  • [Publications] Ueda T,Manabe A,Kikuchi A,Yoshino H,Ebihara Y,Ishii-T,Tsuji K,Nakahata T: "Massive pericardial and pleural effusion with anasarca following allogeneic bone marrow transplantation"Int J Hematol. 71. 394-397 (2000)

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  • [Publications] Ueda T,Yoshino H,Kobayashi K,Asano S,Nakahata T,Tsuji K: "Hematopoietic repopulating ability of cord blood CD34+ cells in NOD/Shi-scid mice"Stem Cells. 18. 204-213 (2000)

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  • [Publications] Matsui A.,Sato T.,Maekawa T.,Asano S.,Nakahata T.,Tsuji K.: "Glycoprotein 130 and c-kit signals synergistically induce thrombopoietin production by hematopoietic cells"Int.J.Hematol. 72. 455-462 (2000)

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  • [Publications] Sato T,Maekawa T,Watanabe S,Tsuji K,Nakahata T: "Erythroid progenitors differentiate and mature in response to endogenous erythropoietin"J Clin Invest. 106. 263-270 (2000)

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  • [Publications] Sasaki S,Ito E,Toki T,Maekawa T,Nakahata T,Igarashi K,Yokoyama M: "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15"Oncogene.. 19. 3739-3749 (2000)

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  • [Publications] Tanaka Y,Naruse I,Xu M,Nakahata T,Maekawa T,Ishii S : "Extensive brain hemorrhage and embyonic lethality in a mouse null mutant of CREB-binding protein."Mechanisms of Development. 95. 133-145 (2000)

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  • [Publications] Ishii T,Manabe A,Ebihara Y,Nakahata T,Asano S,Tuji K: "Improvement in bronchiolitis obliterans organizing pneumonia in a chlid after allogeneic bone marrow transplantation by a combination of oral prednisolone and low dose erythromycin"Bone Marrow Transplantation.. 26. 907-910 (2000)

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  • [Publications] Muroi J,Yorifuji T,Uematsu A,Kitamura A,Nakahata T: "Molecular and clinical analysis of Japanese patients with 3-hydroxy-3-methylgutaryl CoA lyase (HL) deficiency"Hum Genet.. 107. 320-326 (2000)

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  • [Publications] Muroi J,Yorifuji T,Uematsu A,Nakahata T: "Cerebral infarction and pancreatitis : possible complications of patients with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency"J.Inherit.Metab.Dis.. 23. 636-637 (2000)

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  • [Publications] Higuchi Y,Hattori H,Tsuji M,Asato R,Nakahata T: "Partial seizures in leukoencephalopathy with swelling and a discrepantly mild clinical course"Brain & Development. 22. 387-389 (2000)

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  • [Publications] Nakahata T.: "Ex vivo expansion of human hematopoietic stem cells"Int J Hematol.. 73(1). 6-13 (2001)

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  • [Publications] Yoshino H,Ueda T,Kawahata M,Asano S,Nakahata T,Tsuji K: "Natural killer cell depletion by ant asialo GM1 antiserum treatment enhances human hematopoietic stem cell engraftment in NOD/Shi-scid mice"Bone Marrow Transplant. (in press).

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  • [Publications] Sugiyama H,Nonaka T,Tsuji K,Nakahata T: "Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells"FEBS Lett,. (in press).

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  • [Publications] Ma F,Yang F,Kaneko A,Asano S,Nakahata T,Tsuji K: "Cytokine requirement for the development of T-lineage potential from lymphohematopoietic progenitor cells"Br J Haematol,. (in press).

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  • [Publications] Matsuoka S,Ebihara Y,Xu M,Ikeda Y,Nakahata T,Tsuji K: "CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages"Blood. (in press).

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  • [Publications] Xu M,Matsuoka S,Yang F-C,Asano S,Nakahata T,Tsuji K: "Evidence for the presence of primitive megakaryopoiesis in the early yolk sac"Blood. (in press).

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  • [Publications] Yamashita T,Nakahata T.: "Current knowledge on the pathophysiology of fanconi anemia : from genes to pheotypes"Int J Hematol. (in press).

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  • [Publications] Nishikawa M.,Tahara T.,Nakahata T.,Shimosaka A.: "Role of the microenvironment of the embryonic aorta-gonad-mesonephros region in hematopoiesis"Stem Cells. (in press).

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  • [Publications] Sawano A.,Iwai S.,Sakurai Y.,Nakahata T.,Shibuya M.: "Vascular endothelial growth factor receptor-1(Flt-1) is a novel cell surface marker for the lineage of monocyte-macrophages in humans"Blood. (in press).

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  • [Publications] Matsuoka S,Tsuji K,Ikeda Y,Asano S.,Nakahata T: "Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleura by AGM region-derived stromal cells"Blood. (in press).

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  • [Publications] Ma F.,Wada M.,Yoshino,H.,Nakahata,T.,Asano,S.,Tsuji,K.: "Development of human lymphohematopoietic stem/progenitor cells defined by CD34 and CD81 expressions"Blood. (in press).

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  • [Publications] 中畑龍俊: "造血幹細胞のex vivo増幅と臨床応用"Biotherapy. 14. 270-275 (2000)

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  • [Publications] 中畑龍俊: "ヒトES細胞と再生医療"BIO Clinica. 15(6). 322-326 (2000)

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  • [Publications] 久保田優,濱畑啓悟,渡邉健一郎,林英蔚,小石誠二,宇佐美郁哉,中畑龍俊,秋山祐一: "小児赤白血病の3症例:予後因子の文献的考察"臨床血液. 41(3). 212-217 (2000)

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  • [Publications] 中畑龍俊: "造血幹細胞と造血前駆細胞"血液・免疫・腫瘍. 5(3). 251-256 (2000)

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  • [Publications] 前川平,石井武文,西原政道,中畑龍俊: "ヒト造血細胞におけるケモカイン受容体CXCR4の発現動態とその臨床的意義."臨床免疫. 33(1). 99-105 (2000)

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  • [Publications] 中畑龍俊: "造血幹細胞のex vivo増幅と臨床応用"遺伝子医学. 4(2). 246-250 (2000)

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  • [Publications] 今井剛,瀧本哲也,秋山祐一,足立壮一,久保田優,中畑龍俊: "寛解導入不能の縦隔原発T細胞性非ホジキンリンパ腫3例の臨床的検討"日小血会誌. 14. 141-146 (2000)

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  • [Publications] Nakahata T,Xu M,Ueda T,Matsuoka S,Ito M,Tsuji K: "Cell Therapy"Springer. 3 (2000)

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  • [Publications] 中畑龍俊: "サイトカインの造血幹細胞移植への応用"羊土社. 6 (2000)

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  • [Publications] 中畑龍俊: "サイトカインと疾患 1"医学のあゆみ. 5 (2000)

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Published: 2000-04-01   Modified: 2018-03-28  

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