| Project/Area Number |
12307008
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAWAOKA Yoshihiro The University of Tokyo, IMS, Professor, 医科学研究所, 教授 (70135838)
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| Co-Investigator(Kenkyū-buntansha) |
KIDA Hiroshi Hokkaido University, Professor, 大学院, 教授 (10109506)
HORIMOTO Taisuke The University of Tokyo, IMS, Associate Professor, 医科学研究所, 助教授 (00222282)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥48,800,000 (Direct Cost: ¥42,800,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2002: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2001: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2000: ¥22,800,000 (Direct Cost: ¥22,800,000)
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| Keywords | avian influenza virus / H5N1 / reverse genetics / インフルエンザウイルス / リバース・ジェネティクス / 病原性 / 香港 / ヘマグルチニン / HA / 宿主域 / 組織指向性 |
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| Research Abstract |
Influenza is an example of a disease for which the viral pathogen has emerged into the human population many times over past centuries, sometimes with devastating consequences
In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 out of the 18 people infected. When mice were infected with human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was essential requirement for lethal infection.
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