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Preparation of animal model with higher brain dysfunction : studies on evaluation methods of active chemicals

Research Project

Project/Area Number 12357015
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

NOMURA Yasuyuki  Hokkaido Univ., Grad. School of Pharmaceutical Sci., Prof., 大学院・薬学研究科, 教授 (00034041)

Co-Investigator(Kenkyū-buntansha) SYUTO Satoshi  Hokkaido Univ., Grad. School of Pharmaceutical Sci., Ass. Prof., 大学院・薬学研究科, 助教授 (70241346)
MURAYAMA Toshihiko  Chiba Univ., Grad. School of Pharmaceutical Sci., Prof., 大学院・薬学研究科, 教授 (90174317)
OKUMA Yasunobu  Hokkaido Univ., Grad. School of Pharmaceutical Sci., Ass. Prof., 大学院・薬学研究科, 助教授 (20127939)
SAITO Hiroshi  Nihon Univ,. College of Pharmacy, Prof., 薬学部, 教授 (00012625)
UEHARA Takashi  Hokkaido Univ., Grad. School of Pharmaceutical Sci., Ass. Prof., 大学院・薬学研究科, 助教授 (00261321)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥41,570,000 (Direct Cost: ¥35,600,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2002: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2001: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2000: ¥15,700,000 (Direct Cost: ¥15,700,000)
KeywordsSenescence-accelerated mouse (SAM) / quantitative trait Loci analysis (QTL) / learning deficiency / GDNF / neurotrophic factor / phosphatididylinositol 4-kinase / CREB / brain ischemia / Phosphatidylinositol 4-kinase / senescence accelerated mouse (SAM) / インターロイキン-1β / サイトカイン / ミエリン / ハマボウフウ
Research Abstract

Senescence-accelerated mouse prone 8 (SAMP8) shows marked impairment of learning and memory, whereas SAMP10 shows brain atrophy and aging-associated depressive behavior. Hippocampal GDNF mRNA expression in 2-month-old SAMP8 and SAMP10 strains was less than in SAMR1 specimens of the same age. The number of surviving neurons in the CA1 region decreased with age in SAMP8 and SAMP10. These findings suggest that low GDNF expression in young SAMP8 and SAMP10 may be involved in hippocampal dysfunctions, such as age-related learning impairment and neuronal death. We investigated genetic characteristic of learning and memory impairment in SAMP8 by cross-mating between SAMP8 and normal mice, JF1. Results of the incidence of learning deficit in backcross generation and quantitative trait Loci analysis (QTL) suggest that at least one major gene may involves in learning impairment of SAMP8. CV-159, dihydropyridine derivative, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pryridinedicarboxylic acid methyl 6-(5-phenyl-3- pyrazolyloxyl ester that blocks the L-type calcium channel and inhibits the calmodulin-dependent pathway. We found that CV-159 protects against ischemic brain injury. This might be mediated by both blocking the L-type calcium channel and inhibiting calmodulin-dependent function. We have attempted to isolate the genes whose levels were changed in response to transient cerebral ischemia. We found that hippocampal expression of phosphatididylinositol 4-kinase (PI4-K) was decreaed after the brain ischemia, and demonstrated the protective role of PI4-K on ischemia-induced neuronal death. Application of a brief period of ischemia has been known to produce ischemic tolerance. We found that the phosphorylation of CREB in the penumbra region was more rapidly enhanced in the preconditioned rats. The result suggests that the immediate enhancement in the phosphorylation of CREB in penumbra region prevented the spread of infarction in the preconditioned animal.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (115 results)

All Other

All Publications (115 results)

  • [Publications] Maekawa, M. et al.: "Involvement of Hg^<2+>-sensitive sulfhydryl groups in regulating noradrenaline release induced by S-nitrosocysteine in rat brain slices"Biochem. Pharmacol.. 59. 839-845 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishiya, T. et al.: "Involvement of nuclear factor-_κB (NF-_κB)signaling in the expression of inducible nitric oxide synthase (iNOS) gene in rat C6 glioma cells"Biochem. Biophys. Res. Commun.. 275. 268-273 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maekawa, M. et al.: "Stimulation of noradrenaline release by T-588, a cognitive enhancer, in PC12 cells"Jpn. J. Pharmacol.. 82(1). 59-66 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka, S. et al.: "Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death"J. Biol. Chem.. 275(14). 10388-10393 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitamura, T. et al.: "Enhancement of Ca^<2+>-induced noradrenaline release by vanadate in PC12 cells : possible involvement of tyrosine phosphorylation"Brain Res.. 854. 165-171 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazaki, H.et al.: "Glial cell line-derived neurotrophic factor modulates ischemia-induced tyrosine hydroxylase expression in rat hippocampus"Europ. J. Neurosci.. 12. 2032-2038 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, A.et al.: "Isolation of 1ch-1S (caspase-2S)-binding protein that partially inhibits caspase activity"FEBS Lett.. 470. 360-364 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshinaga, N. et al.: "Possible involvement of cytosolic phospholipase A_2 in cell death induced by 1-methyl-4-phenylpyridinium ion (MPP^+),a dopaminergic neurotoxin, in GH3 cells"Brain Res.. 855. 244-251 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okuma, Y. et al.: "Learning deficiency and alterations in acetylcholine receptors and protein kinase C in the brain of senescence-accelerated mouse (SAM)-P10"Mech. Ag. Develop.. 114. 191-199 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Electrical stimulation of afferent vagus nerve induces IL-1β expression in the brain and activated HPA axis"Am. J. Physiol.. 279. R141-R147 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera, T. et al.: "Depressive behavior and alteration in receptors of dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10"Jpn. J. Pharmacol.. 83. 312-318 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshinaga, N. et al.: "Apoptosis induction by a dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP^+), and inhibition by epidermal growth factor in GH3 cells"Biochem. Pharmacol.. 60. 111-120 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mitsuhashi, S. et al.: "Development of an assay method for activities of serine/threonine protein phosphatase type 2B (calcineurin) in crude extracts"Anal. Biochem.. 278. 192-197 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Thang, S.H.et al.: "Inhibition of phospholipase A_2 activity by S-nitroso-cystein in a cyclic GMP-Independent manner in PC12 cells"Europ. J. Pharmacol.. 395. 183-191 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitamura, Y. et al.: "Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures"J. Neuroimmunol.. 106. 95-104 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Naganuma, T. et al.: "Effects of S-nitroso-cysteine on proteins that regulate exocytosis in PC12 cells : inhibitory effects on translocation of synaptophysin and ADP-ribosylation of GTP-binding proteins"Jpn. J. Pharmacol.. 84. 391-398 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tha, K K. et al.: "Changes in expressions of proinflammatory cytokines IL-1β,TNF-α and IL-6 in the brain of senescence accelerated mouse (SAM) P8"Brain Res.. 885. 25-31 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Expression of leptin receptors and induction of IL-1_β transcript in glial cells"Biochem. Biophys. Res. Commun.. 273. 312-315 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujino, H. et al.: "Extracellular signal regulated protein kinase c-Jun N-terminal kinase are involved in m1 muscarinic receptor-enhanced interleukin-2 production pathway in Jurkat cells"Biol. Pharm. Bull.. 23(10). 1198-1205 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Moriya, R. et al.: "The mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells"FEBS Lett.. 484. 253-260 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitamura, Y. et al.: "Effects of 15-deoxy-Δ^<12,14> prostaglandin J_2 and interluekin-4 in Toll-like recoptor-4-mutant glial cells"Europ. J. Pharmacol.. 411. 223-230 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kakimura, J. et al.: "Release and aggregation of cytochrome c and α-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole"Europ. J. Pharmacol.. 417. 59-67 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mori, A. et al.: "Enhancement of arachidonic acid release and prostaglandin F_<2α> formation by Na_3VO_4 in PC12 cells and GH3 cells"Erop. J. Pharmacol.. 417. 19-25 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maekawa, M. et al.: "Involvement of noradrenaline transporters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices : existence of functional Na^+-independent transporter activity"Neurochem. Int.. 38. 323-331 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitamura, Y. et al.: "Lipopolysaccharide-induced switch between retinoid receptor (RXR)α and glucocorticoid attenuated response gene (GARG):messenger RNAs in cultured rat microglia"J. Neurosci. Res.. 64. 553-563 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazaki, H. et al.: "Expression of glial cell line-derived neurotrophic factor induced by transient forebrain ischemia in rats"Brain Res.. 922. 165-172 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nemoto, T. et al.: "Possible involvement of acid transporters on S-nitroso-cysteine-induced inhibition of arachidonic acid release in PC12 cells"Neurosci. Lett.. 311. 117-120 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazaki, H. et al.: "Expression of ret receptor tyrosine kinase after transient forebrain ischemia is modulated by glial cell line-derived neurotrophic factor in rat hippocampus"Neurosci. Lett.. 318. 1-4 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1β expression in the hypothalamus"Am. J. Physiol.. 282. R627-R631 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Araya, R. et al.: "Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28γ as an effector caspase substrate"Cell Death Differ.. 9. 322-328 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Leptin induces IL-1 receptor antagonist expression in the brain"Biochem. Biophys. Res. Commun.. 294. 215-219 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kakimura, J. et al.: "Microglial activation and amyloid-βclearance induced by exogenous heat-shock proteins"Faseb J.. 16. 601-603 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohsawa, K. et al.: "Arachidonic acid release and prostaglandin F_<2α> formation induced by phenylarsine oxide in PC12 cells : possible involvement of secretory phospholipase A_2 activity"Biochem. Pharmacol.. 64. 117-124 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Brain stem is a direct target for leptin's action in the CNS"Endocrinology. 143(9). 3498-3504 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ko, H.S.et al.: "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death"J. Biol. Chem.. 277(38). 35386-35392 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Leptin regulates IL-1β expression in the brain via the STAT3-independent mechanisms"Brain Res.. 949. 139-146 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tohda, M. et al.: "The mRNA expression of serotonin 2C subtype receptors uncoupled With inositol hydrolysis in NG108-15 cells"Jpn. J. Pharmacol.. 90. 138-144 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kaneko, M. et al.: "Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation"FEBS Lett.. 532. 147-152 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakajima, T. et al.: "Relationship between the activation of cyclic AMP responsive element binding protein and ischemic tolerance in the penumbra region of rat cerebral cortex"Neurosci. Lett.. 331. 13-16 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nomura, J. et al.: "The presence and the functions of mnscariric receptors in human T cells : The involvement in IL-2 and IL-2 receptors system"Life Sci.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nomura, J. et al.: "Aβ-induced TNF-α expression and acetylcholine action in mouse glial cells"Life Sci.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Inhibition of leptin-induced IL-1βexpression by glucocorticoids in the brain"Brain Res.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 東田道久 他: "廣川ニューロサイエンス3,新しい神経伝達研究法II(三木直正,野村靖幸 編)"廣川書店. 157-167 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 野村靖幸: "第14改訂 日本薬局方解説書(重信弘毅 編)"廣川書店. (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 村山俊彦 他: "生物学データ集(石原勝敏他 編)"朝倉書店. 1221-1231 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 野村靖幸: "南山堂医学大辞典"南山堂(印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 野村靖幸: "ファーマシューティカルノート(百瀬彌寿徳 編)"医学評論社(印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maekawa, M. et al.: "Involvement of Hg^<2+>-sensitive sulfhydryl groups in regulating noradrenaline release induced by S-nitrosocysteine in rat brain slices"Biochem. Pharmacol.. 59. 839-845 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nishiya, T. et al.: "Involvement of nuclear factor-_κB (NF-_κB) signaling in the expression of inducible nitric oxide synthase (iNOS) gene in rat C6 gliom a cells"Biochem. Biophys. Res. Commun.. 275. 268-273 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maekawa, M. et al.: "Stimulation of noradrenaline release by T-588, a cognitive enhancer, in PC12 cells"Jpn. J. Pharmacol.. 82(1). 59-66 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tanaka, S. et al.: "Up-regulation of protein-disulfide isomerase in resonse to hypoxia/brain ischemia and its protective effect against apoptotic cell death"J. Biol. Chem.. 275(14). 10388-10393 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitamura, T. et al.: "Enhancement of Ca^<2+>-induced noradrenaline release by vanadate in PC12 cells : possible involvement of tyrosine phosphorylation"Brain Res.. 854. 165-171 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazaki, H. et al.: "Glial cell line-derived neurotrophic factor modulates ischemia-induced tyrosine hydroxylase expression in rat hippocampus"Europ. J. Neurosci.. 12. 2032-2038 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ito, A. et al.: "Isolation of 1ch-1S (caspase-2S)-binding protein that partially inhibits caspase activity"FEBS Lett.. 470. 360-364 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshinaga, N. et al.: "Possible involvement of cytosolic phospholipase A_2 in cell death induced by 1-methyl-4-phenylpyridinium ion (MPP^+), a dopaminergic neurotoxin, in GH3 cells"Brain Res.. 855. 244-251 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okuma, Y. et al.: "Learning deficiency and alterations in acetylcholine receptors and protein kinase C in the brain of senescence-accelerated mouse (SAM)-P10"Mech. Ag. Develop.. 114. 191-199 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Electrical stimulation of afferent vagus nerve induces IL-1β expression in the brain and activates HPA axis"Am. J. Physiol.. 279. R141-R147 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Onodera, T. et al.: "Depressive behavior and alteration in receptors for dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10"Jpn. J. Pharmacol.. 83. 312-318 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshinaga, N. et al.: "Apoptosis induction by a dopaminergic neurotoxin, 1-methyl-4-pheylpyridinium ion (MPP^+), and inhibition by epidermal growth factor in GH3 cells"Biochem. Pharmacol.. 60. 111-120 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mitsuhashi, S. et al.: "Development of an assay method for activities of serine/threonine protein phosphatase type 2B (calcineurin) in crude extarcts"Anal. Biochem.. 278. 192-197 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Thang, S. H. et al.: "Inhibition of phospholipase A_2 activity by S-nitroso-cysteine in a cyclic GMP-independent manner in PC12 cells"Europ. J. Pharmacol.. 395. 183-191 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitamura, Y. et al.: "Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures"J. Neuroimmunol.. 106. 95-104 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Naganuma, T. et al.: "Effects of S-nitroso-cysteine on proteins that regulate exocytosis in PC12 cells : inhibitory effects on translocation of synaptophysin and ADP-ribosylation of GTP-binding proteins"Jpn. J. Pharmacol.. 84. 391-398 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tha, K. K. et al.: "Changes in expressions of proinflammatory cytokines IL-1β, TNF-α and IL-6 in the brain of senescence accelerated mouse (SAM)P8"Brain Res.. 885. 25-31 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Expression of leptin receptors and induction of IL-1_β transcript in glial cells"Biochem. Biophys. Res. Commun.. 273. 312-315 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujino, H. et al.: "Extracellular signal regulated protein kinase and c-Jun N-terminal kinase are involved in m1 muscarinic receptor-enhanced interleukin-2 production pathway in Jurkat cells"Biol. Pharm. Bull.. 23(10). 1198-1205 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Moriya, R. et al.: "The mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells"FEBS Lett.. 484. 253-260 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kitamura, Y. et al.: "Effects of 15-deoxy-Δ^<12, 14> prostaglandin J_2 and interluekin-4 in Toll-like receptor-4-mutant glial cells"Europ. J. Pharmacol.. 411. 223-230 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kakimura, J. et al.: "Release and aggregation of cytochrome c and α-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole"Europ. J. Pharmacol.. 417. 59-67 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mori, A. et al.: "Enhancement of arachidonic acid release and prostaglandin F_<2α> formation by Na_3VO_4 in PC12 cells and GH3 cells"Erop. J. Pharmacol.. 417. 19-25 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Maekawa, M. et al.: "Involvement of noradrenaline transoprters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices : existence of functional Na^+-independent transporter activity"Neurochem. Int.. 38. 323-331 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kitamura, Y. et al.: "Lipopolysaccharide-induced switch between retinoid receptor (RXR)α and glucocorticoid attenuated response gene (GARG) : sixteen messenger RNAs in cultured rat microglia"J. Neurosci. Res.. 64. 553-563 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazaki, H. et al.: "Expression of glial cell line-derived neurotrophic factor induced by transient forebrain ischemia in rats"Brain Res.. 922. 165-172 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nemoto, T. et al.: "Possible involvement of amino acid transporters on S-nitroso-cysteine-induced inhibition of arachidonic acid release in PC12 cells"Neurosci. Lett.. 311. 117-120 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazaki, H. et al.: "Expression of ret receptor tyrosine kinase after transient forebrain ischemia is modulated by glial cell line-derived neurotrophic factor in rat hippocampus"Neurosci. Lett.. 318. 1-4 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1β expression in the hypothalamus"Am. J. Physiol.. 282. R627-R631 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Araya, R. et al.: "Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28γ as an effector caspase substrate"Cell Death Differ.. 9. 322-328 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Leptin induces IL-1 receptor antagonist expression in the brain"Biochem. Biophys. Res. Commun.. 294. 215-219 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kakimura, J. et al.: "Microglial activation and amyloid-βclearance induced by exogenous heat-shock proteins"Faseb J.. 16. 601-603 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohsawa, K. et al.: "Arachidonic acid release and prostaglandin F_<2α> formation induced by phenylarsine oxide in PC12 cells : possible involvement of secretory phospholipase A_2 activity"Biochem. Pharmacol.. 64. 117-124 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Brain stem is a direct target for leptin's action in the CNS"Endocrinology.. 143(9). 3498-3504 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ko, H. S. et al.: "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death"J. Biol. Chem.. 277(38). 35386-35392 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Leptin regulates IL-1β expression in the brain via the STAT3-independent mechanisms"Brain Res.. 949. 139-146 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tohda, M. et al.: "The mRNA expression of serotonin 2C subtype receptors uncoupled with inositol hydrolysis in NG108-15 cells"Jpn. J. Pharmacol.. 90. 138-144 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Kaneko, M. et al.: "Human HRD1 protects against ER sterss-induced apoptosis through ER-associated degradation"FEBS Lett.. 532. 147-152 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakajima, T. et al.: "Relationship between the activation of cyclic AMP resopnsive element binding protein and ischemic tolerance in the penumbra region of rat cerebral cortex"Neurosci. Lett.. 331. 13-16 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nomura, J. et al.: "The presence and the functions of mnscariric receptors in human T cells : The involvement in IL-2 and IL-2 receptor system"Life Sci.. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nomura, J. et al.: "Aβ-induced TNF-α expression and acetylcholine action in mouse glial cells"Life Sci.. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hosoi, T. et al.: "Inhibition of leptin-induced IL-1β expression by glucocorticoids in the brain"Brain Res.. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazaki, H. et al.: "Expression of ret receptor tyrosine kinase after transient forebrain ischemia is modulated by glial cell line-derived neurotrophic factor in rat hippocampus"Neurosci.Lett.. 318. 1-4 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hosoi, T. et al.: "Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1β expression in the hypothalamus"Am.J.Physiol.. 282. R627-R631 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Araya, R. et al.: "Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28γ as an effector caspase substrate"Cell Death Differ.. 9. 322-328 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hosoi, T. et al.: "Leptin induces IL-1 receptor antagonist expression in the brain"Biochem.Biophys.Res.Commun.. 294. 215-219 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kakimura, J. et al.: "Microglial activation and amyloid-β clearanced induce by exogenous heatshock proteins"Faseb J.. 16. 601-603 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohsawa, K. et al.: "Arachidonic acid release and prostaglandin F_<2α> formation induced by phenylarsine oxide in PC12 cells : possible involvement of secretory phospholipase A_2 activity"Biochem.Pharmacol.. 64. 117-124 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hosoi, T. et al.: "Brain stem is a direct target for leptin's action in the CNS"Endocrinology. 143(9). 3498-3504 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ko, H.S.et al.: "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death"J.Biol.Chem.. 277(38). 35386-35392 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hosoi, T. et al.: "Leptin regulates IL-1β expression in the brain via the STAT3-independent mechanisms"Brain Res.. 949. 139-146 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tohda, M. et al.: "The mRNA expression of serotonin 2C subtype receptors uncoupled with inositol hydrolysis in NG108-15 cells"Jpn.J.Pharmacol.. 90. 138-144 (2002)

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  • [Publications] Kaneko, M. et al.: "Hunman HRD1 protects against ER stress-induced apoptosis through ER-associated degradation"FEBS Lett.. 532. 147-152 (2002)

    • Related Report
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  • [Publications] Nakajima, T. et al.: "Relationship between the activation of cyclic AMP responsive element binding protein and ischemic tolerance in the penumbra region of rat cerebral cortex"Neurosci. Lett.. 331. 13-16 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nomura, J. et al.: "The presence and the functions of mnscariric receptors in human T cells : The involvement in IL-2 and IL-2 receptor system"Life Sci.. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Nomura, J. et al.: "Aβ-induced TNF-α expression and acetylcholine action in mouse glial cells"Life Sci.. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Hosoi, T. et al.: "Inhibition of leptin-induced IL-1β expression by glucocorticoids in the brain"Brain Res.. (in press).

    • Related Report
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  • [Publications] 野村靖幸: "南山堂医学大辞典"南山堂(印刷中). (2002)

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  • [Publications] 野村靖幸: "ファーマシューティカルノート(百瀬彌寿徳 編)"医学評論社(印刷中). (2002)

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  • [Publications] Kitamura, Y., Kakimura, J., Koike, H., Umeki, M., Gebicke-Haerter P-J., Nomura, Y., Taniguchi T.: "Effects of 15-deoxy-_△^<12,14> prostaglandin J_2 and interleukin4 in Toll-like receptor-4-mutant glial cells"Europ.J.Pharmacol.. 411. 223-230 (2001)

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  • [Publications] Miyazaki, H., Nagashima, K., Okuma, Y., Nomura, Y.: "Expression of glial cell line-derived neurotrophic factor induced by transient forebrain ischemia in rats"Brain Res.. 922. 165-172 (2001)

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  • [Publications] Nomura, Y.: "NF-κB activation and IκBα dynamism involved in iNOS and chemokine induction in astroglial cells"Life Sciences.. 68. 1695-1701 (2001)

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  • [Publications] 野村 靖幸: "うつ病の薬物治療研究の発展を"治療学. 34(12). 20 (2000)

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  • [Publications] 野村 靖幸: "脳神経系の細胞膜受容体応答とストレス応答に関する細胞分子薬理学的研究"薬学雑誌. 121(12). 899-908 (2001)

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  • [Publications] Miyazaki, H.et al: "Glial cell line-dereived neurotrophic factor modulates ischemia-induced tyrosine hydroxylase expression in rat hippocampus."Europ.J.Neurosci.. 12. 2032-2038 (2000)

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  • [Publications] Okuam, Y.et al: "Learning deficiency and alterations in acetylcholine receptors and protein kinase C in the brain of senescence-accelerated mouse (SAM)-P10."Mech.Ag.Develop.. 114. 191-199 (2000)

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  • [Publications] Onodera T.et al: "Depressive behavior and alteration in receptors for dopamine and 5-hydroxytrptamine in the brain of senescence acceleated mouse (SAM)-P10."Jpn.J.Pharmacol.. 83. 312-318 (2000)

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  • [Publications] Tha, K.K.et al: "Changes in expressions of proinflammatory cytokines IL-1β, TNF-α and IL-6 in the brain of senescence accelerated mouse (SAM) P8."Brain Res.. 885. 25-31 (2000)

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Published: 2000-04-01   Modified: 2016-04-21  

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