| Project/Area Number |
12470055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | OSAKA UNIVERSITY |
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Principal Investigator |
TAKEDA Junji COLLABORATIVE RESEARCH CENTER FOR ADVANCED SCIENCE AND TECHNOLOGY, PROFESSOR, 先端科学技術共同研究センター, 教授 (50163407)
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| Co-Investigator(Kenkyū-buntansha) |
KONDOH Gen GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学系研究科, 助教授 (40243258)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2002: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2001: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2000: ¥6,100,000 (Direct Cost: ¥6,100,000)
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| Keywords | Conditional gene targeting / Cre / loxP / T lymphocytes / LCB2 / Sphingolipid / Epidermis / トランスジェニックマウス / コンディショナルジーンターゲティング / LCB2遺伝 |
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| Research Abstract |
To investigate role of sphingolipid in vivo, we generated conditional LCB2 gene-targeted mice.
1. Skin specific sphingolipid deficient mice
Skin contain abundant sphingolipids different from other organs. The sphingolipids may play important roles for maintenance of barrier function. Therefore we generated skin specific sphingolipid deficient mice. These mice die 3 weeks after birth probably due to impaired barrier function.
2. T cell specific sphingolipid deficient mice
Sphlingolipid deficient T cells poorly undergo cell maturation in thymus.
This result implicate that sphlingolipid play important role for T cell selection in thymus.
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