| Project/Area Number |
12480208
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAWAKAMI Koichi The University of Tokyo, The Institute of Medical Science, Assistant Professor, 医科学研究所, 助手 (70195048)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Shigeru Tokushima University, Faculty of the Integrated Art and Sciences, Professor, 総合科学部, 教授 (10252503)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥14,700,000 (Direct Cost: ¥14,700,000)
Fiscal Year 2001: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2000: ¥9,100,000 (Direct Cost: ¥9,100,000)
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| Keywords | pattern formation / zebrafish / ubiquitin / reaction-diffusion system / mutation / position information / molecular biology / developmental genetics / 色素パターン / トランスポゾン / 突然変異 / 皮膚 / 黒色素胞 / キメラ / 移植実験 |
|---|
| Research Abstract |
(1) We have isolated the zebrafish hagoromo mutations which caused abnormal stripe pattern on the skin.
(2) We showed the zebrafish hagoromo gene, encoding a novel F-box/WD40 repeat-protein, is an ortholog of the mouse Dactylin gene.
(3) We showed a small alteration in the hagoromo gene expression caused the mutant phenotype.
(4) We established a mathematical model showing the stripe pattern on the fish skin.
(5) We showed that a small change in a parameter of the equation can change the stripe pattern.
(6) We showed that the hagoromo F-box/WD40 protein is a component of the SCF-ubiquitin ligase complex.
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