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Approach to the cure oriented therapy for chronic renal disease by the establishment of a disease model mouse strain which shows naturally occurring nephritic syndrome

Research Project

Project/Area Number 12480252
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionOsaka University

Principal Investigator

KUROSAWA Tsutomu  Osaka University, Medical School, Associate Professor, 医学部, 助教授 (60129997)

Co-Investigator(Kenkyū-buntansha) TATSUMI Haruyuki  Sapporo Medical College, Professor, 教授 (90171719)
AGUIN Takashi  Hokkaido University, Graduate School of Veterinary, Professor, 獣医学部, 教授 (00212457)
MANABE Noboru  Kyoto University, Graduate School of Agriculture, Associate Professor, 農学部, 助教授 (80243070)
TAJIMA Masaru  Osaka University, Graduate School of Medicine, Assistant Professor, 医学部, 助手 (10227077)
OGURA Atsurou  Riken Tsukuba Institute Bio Resource Center Engineering Division Head, 遺伝工学基盤技術室, 室長(研究職) (20194524)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2001: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2000: ¥6,200,000 (Direct Cost: ¥6,200,000)
KeywordsDisease model / Chronic renal disease / Disease analysis / Genetic analysis / SPF animal / Gene resources / Gene therapy / Treatment with cytokines / ネフローゼ / 慢性腎不全 / モデルマウス / TGF-β / α・SMA / HGF / α-SMA
Research Abstract

Many of conquest of an incurable disease has been terminated by development of a suitable animal used disease models. Since the citizen of at least 200,000 or more present our countries is chronic renal disease, kidney dialysis medical treatment is received, and the number of patients which newly goes into dialysis has also become about 30,000 people every year. Although kidney dialysis is the symptomatic therapy which was extremely excellent as an internal medical-treatment of chronic renal disease, not a radical cure treatment but original kidney disease cannot be made to recover. Kidney dialysis has become the degree which shakes even the universal national health insurance system which leads to the increase in a patient, and the increase in conjointly immense medical expenses, and our country is proud of. We decided to explore the way to the radical cure medical treatment of the chronic renal disease which is one of the incurable diseases paying attention to the naturally occurring nephrosis mouse discovered by the National Institute of Infectious Disease. It strives for the establishment of animal- disease-modeling strain and its maintenance first, and two research organizations are performing strain of mouse maintenance now. Since the high disease model system of quality was maintainable in microbiology, the overseas 2 research organizations and the domestic 8 research organizations were able to be apportioned to the system. The main responsible gene was mapped on the No. 15 chromosome, and the still more detailed gene location was clarified. Because all mouse DNA sequence was released, the main part of the responsible gene of this model is also expected to be solved soon. The usefulness of this strain of mouse increased. According to the result of this research project, it is suggested that the gene therapy of cytokine is suitable for chronic renal insufficiency, and research of gene therapy is done now using this model.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (78 results)

All Other

All Publications (78 results)

  • [Publications] Mizuno, S.: "Reciprocal balance of hepatocyte growth factor and transforming growth factor-1 in renal fibrosis in mice"Kidney Int.. 57. 937-948 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Interleukin-2 (IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IL-2"Animal Biochemistry. 36(2). 39-45 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawashima, K.: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"Am.J.Vet.Res.. 61(9). 1080-1086 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno-Horikawa, Y.: "Advanced Glomerulosclerosis Is Reversible in Nephrotic Mice"Biochem.Biophys.Res.Commun.. 284(3). 707-713 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Immunohistochemical Analysis of Molecular Events in Tubulo-Interstitial Fibrosis in a Mouse Model of Diffuse Mesangial Sclerosis (ICGN Strain)"J.Vet.Med.Sci.. 63(3). 299-307 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamamoto, H.: "Microbiological Contamination in Genetically Modified Animals and Proposals for a Microbiological Test Standard for National Universities in Japan"Exp.Anim.. 50(5). 397-407 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawashima, K.: "Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction"Exp.Nephrol.. 10. 7-18 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto, M.: "Linkage Mapping of the Mouse Nephrosis(nep) Gene to Chromosome15"J.Vet.Med.Sci.. 63(12). 1347-1350 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tamura, K.: "Characteristic changes in carbohydrate profile in the kidneys of hereditary nephrotic mice (ICGN strain)"J.Vet.Med.Sci.. 62(4). 379-390 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchio, K.: "Decreased matrix metalloproteinase activity in be kidneys of hereditary nephrotic mice (ICGN strain)"Nephron. 86. 145-151 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Manabe, N.: "Changes in quantitative profile of extracellular matrix components in the kidneys of rats with adriamycin-induced nephropathy"J.Vet.Med.Sci.. 63(2). 125-133 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamaguchi, M.: "localization of proliferative and apoptotic cells in the kidneys of ICR-derived glomerulonephritis (ICGN) mice"J.Vet.Med.Sci.. 63(7). 781-787 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchio-Yamada, K.: "Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome"J.Vet.Med.Sci.. 63(11). 1171-1178 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Uchio, K.: "Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts"Laboratory Investigation. 82. 619-628 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 黒澤 努: "慢性腎不全発症マウスモデルの血清生化学値の特徴"日本疾患モデル学会記録. 16. 12-12 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 黒澤 努: "慢性腎疾患の病態形成に関与するHGF、TGF-βの役割"炎症と免疫. 9(3). 87-95 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 澤嶋 功: "猫の慢性腎疾患における糸球体濾過値の低下と間質の線維化程度の相開"日獣会誌. 54. 687-691 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 黒澤 努: "マイクロアイソレーターシステム(VIC)の簡易改良について"実験動物と環境. 10(1). 53-54 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 澤嶋 功: "低蛋白食によるネコの慢性腎不全の進行抑制"日獣会誌. 55. 591-595 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada-Uchio, K.: "Abnormalities of extracellular matrix metabolisms in the kidney of ICGN mice, a strain of mice with hereditary nephrotic syndrome"Reproductive Biotechnology : Reproductive biotechnology update and its related physiology (Hokuto Pub. Co.). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamaguchi, M.: "Renal anemia in ICR-derived glomerulonephritis (ICGN) mice"Reproductive Biotechnology : Reproductive biotechnology update and its related physiology (Hokuto Pub. Co.). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamaguchi-Yamada, M.: "Anemia associated with renal failure in the ICR-derived glomerulonephritis (ICGN) mice"Animal Frontier Science(Hokuto Pub. Co.). 364 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Inteleukin-2 (IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Kidney Int.. 57. 937-948 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Inteleukin-2 (IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Animal Biochemistry. 36 (2). 39-45 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawashima, K.: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"Am. J. Vet. Res.. 61 (9). 1080-1086 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno-Horikawa, Y.: "Advanced Glomerulosclerosis Is Reversible in Nephrotic Mice"Biochem. Biophys. Res. Commun.. 284 (3). 707-713 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Immunohistochemical Analysis of Molecular Events in Tubulo-Interstitial Fibrosis in a Mouse Modal of Diffuse Mesangial Sclerosis (ICGN Strain)"J.Vet.Med.Sci.. 63 (3). 299-307 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamamoto,H.: "Microbiological Contamination in Genetically Modified Animals and Proposals"Exp.Anim.. 50 (5). 397-407 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawashima, K.: "Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction"Exp.Nephrol.. 10. 7-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto, M.: "Linkage Mapping of the Mouse Nephrosis(nep) Gene to Chromosome 15"J.Vet.Med.Sci.. 63(12). 1347-1350 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Interleukin-2 (IL-2)-dependemt growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Kidney Int.. 57. 937-945 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Interleukin-2 (IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Animal Biochemistry. 36 (2). 39-45 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawashima, K.: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"Am. J. Vet. Res.. 61 (9). 1080-1086 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno-Horikawa, Y.: "Advanced Glomerulosclerosis Is Reversible in Neplrotic Mice"Biochem. Biophys. Res. Commun.. 284 (3). 707-713 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Immunohistochemical Analysis of Molecular Events in Thbulo-Interstitial Fibrosis in a Mouse Model of Diffuse Mesangial Sclerosis (ICGN Strain)"J.Vet.Med.Sci.. 63 (3). 299-307 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamamoto,H.: "Microbiological Contamnation in Genetically Modified Animals and Proposals"Exp.Anim.. 50 (5). 397-407 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawashima, K.: "Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction"Exp. Nephrol.. 10. 7-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Okamoto, M.: "Linkage Mapping of the Mouse Nephrosis(nep) Gene to Chromosome 15"J.Vet.Med.Sci.. 63(12). 1347-1350 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawashima, K.: "Correlation between Renal Function and Tubulo-interstitial Lesions in Feline Progressive Kidney Disease"J. Jpn. Vet. Med. Assoc.. 54. 687-691 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kurosawa, T.: "A simple improvement of a Micro-Isolation-System(VIC)"Laboratory Animal and Environment. 10 (1). 53-54 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sawashima, K.: "Inhibition of Naturally Occurring Feline Chronic Renal Failure by Dietary-protein Restriction"J. Jpn. Vet. Med. Assoc.. 55. 591-595 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamada-Uchio, K.: "Abnormalities of extracellular matrix metabolisms in the kidney of ICGN mice, a strain of mice with hereditary nephrotic syndrome. In : Reproductive Biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Pub. Co.. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamaguchi, M.: "Renal anemia in ICR-derived glomerulonephritis (ICGN) mice. In : Reproductive Biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Pub. Co.. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamaguchi-Yamada, M: "Anemia associated with renal failure in the ICR-derived glomerulonephritis (ICGN) mice. In : Animal Frontier Science"Hokuto Pub. Co.. 364 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Mizuno, S.: "Reciprocal balance of hepatocyte growth factor and transforming growth factor-1 in renal fibrosis in mice"Kidney International. 57. 937-948 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mizuno, S: "Interleukin-2(IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Animal Biochemistry. 36(2). 937-948 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sawashima, K: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"Am. J. Vet. Res.. 61(9). 1080-1086 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoko Mizuno-Horikawa: "Immunohistochemical Analysis of Molecular Events in Tubulo-Interstitial Fibrosis in a Mouse Model of Diffuse Mesangial Sclerosis(ICGN Strain)"Biochemical and Biophysical Research Communications. 284(3). 707-713 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamamoto, H: "Microbiological Contamination in Genetically Modified Animals and Proposals for a Microbiological Test Standard for National Universities in Japan"Exp. Anim.. 50(5). 397-407 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sawashima, K: "Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction"Exp. Nephrol.. 10. 7-18 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Munehiro OKAMOTO: "Linkage Mapping of the Mouse Nephrosis(nep) Gene to Chromosome 15"J. Vet. Med. Sci. 63(2). 1347-1350 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kotaro Tamura: "Characteristic changes in carbohydrate profile in the kidneys of hereditary nephrotic mice (ICGN strain)"The Journal of Veterinary Medical Science. 62(3). 379-390 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kozue Uchio: "Decreased matrix metalloproteinase activity in the kidneys of hereditary nephrotic mice (ICGN strain)"Nephron. 86(2). 145-151 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Noboru Manabe: "Changes in quantitative profile of extracellular matrix components in the kidneys of rats with adriamycin-induced nephropathy"The Journal of Veterinary Medical Science. 62(1). 125-133 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Misuzu Yamaguchi: "localization of proliferative and apoptotic cells in the kidneys of ICR-derived glomerulonephritis (ICGN) mice"The Journal of Veterinary Medical Science. 62(7). 781-787 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kozue Uchio-Yamada: "Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome"The Journal of Veterinary Medical Science. 62. 1171-1178 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kozue Uchio: "Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts"Laboratory Investigation. 82. 619-628 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 黒澤 努: "慢性腎不全発症マウスモデルの血清生化学値の特徴"日本疾患モデル学会記録. 16. 12-12 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] 黒澤 努: "慢性腎疾患の病態形成に関与するHGF、TGF-βの役割"炎症と免疫. 9(3). 87-95 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 澤嶋 功: "猫の慢性腎疾患における糸球体濾過値の低下と間質の線維化程度の相関"日獣会誌. 54. 687-691 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 黒澤 努: "マイクロアイソレーターシステム(VIC)の簡易改良について"実験動物と環境. 10(1). 53-54 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 澤嶋 功: "低蛋白食によるネコの慢性腎不全の進行抑制"日獣会誌. 55. 591-595 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kozue Yamada-Uchio: "Abnormalities of extracellular matrix metabolisms in the kidney of ICGN mice, a strain of mice with hereditary nephrotic syndrome. In : Reproductive Biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Pub. Co.. 424 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Misuzu Yamaguchi: "Renal anemia in ICR-derived glomerulonephritis (ICGN) mice. In : Reproductive Biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Pub. Co.. 424 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Misuzu Yamaguchi-Yamada: "Anemia associated with renal failure in the ICR-derived glomerulonephritis (ICGN) mice. In : Animal Frontier Science"Hokuto Pub. Co.. 364 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kozue UCHIO: "Abnormalities of Extracellular Matrices and Transforming Growth Factor β 1 Localization in the Kidney of the Hereditary Nephrotic Mice(ICGN Strain)"J.Vet.Med.Sci. 61(7). 769-776 (1999)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kotaro TAMURA: "Characteristic Changes in Carbohydrate Profile in the Kidneys of Hereditary Nephrotic Mice(ICGN Strain)"J.Vet.Med.Sci. 62(4). 379-390 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kozue Uchio: "Decreased Matrix Metalloproteinase Activity in the Kidneys of Hereditary Nephrotic Mice(ICGN Strain)"Nephron. 86. 145-151 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sawashima, K: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"Am.J.Vet.Res.. 61(9). 1080-1086 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mizuno, Shinya: "Reciprocal balance of hepatocyte growth factor and transforming growth factor-1 in renal fibrosis in mice"Kidney International. 57. 937-948 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mizuno, Shinya: "Immunohistochemical Analysis of Molecular Events in Tubulo-Interstitial ibrosis in a Mouse Model of Diffuse Mesangial Sclerosis(ICGN Strain)"Lab.Anim.Sci.. 63(3). 299-307 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mizuno-Horikawa, Y: "Advanced glomerulosclerosis is reversible in nephrotic mice"Biochem Biophys Res Commun. 284(3). 707-713 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sawashima, K: "Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expressionin unilateral ureteral obstruction"Exp. Nephrol. (In print). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kozue UCHIO: "Abnormalities of Extracellular Matrices and Transforming Growth Factor β1 Localization in the Kidney of the Hereditary Nephrotic Mice (ICGN Strain)"J.Vet.Med.Sci.. 61(7). 769-776 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kotaro TAMURA: "Characteristic Changes in Carbohydrate Profile in the Kidneys of Hereditary Nephrotic Mice (ICGN Strain)"J.Vet.Med.Sci.. 62(4). 379-390 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kozue Uchio: "Decreased Matrix Metalloproteinase Activity in the Kidneys of Hereditary Nephrotic Mice (ICGN Strain)"Nephron. 86. 145-151 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ko Sawashima,DVM: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"AJVR,. Vol 61,No.9,. 1080-1086 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shinya Mizuno: "Reciprocal balance of hepatopyte growth factor and transforming growth factor-β 1 in renal fibrosis in mice"Kidney International,. Vol.57. 937-948 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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