| Project/Area Number |
12556051
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Applied veterinary science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
TAKASHIMA Ikuo Hokkaido Univ., Grad. School of Vet. Med., Prof, 大学院・獣医学研究科, 教授 (30002083)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kenichi Hokkaido Inst. Of Pub. Health., Sect. of Med Zool., Head, 疫学部, 科長
MIZUTANI Tetsuya Hokkaido Univ., Grad. School of Vet. Med., Instr, 大学院・獣医学研究科, 助手 (70281681)
KARIWA Hiroaki Hokkaido Univ., Grad. School of Vet. Med., Assoc. Prof, 大学院・獣医学研究科, 助教授 (70224714)
KURATA Takeshi National Inst of Infectious Diseases, Deputy Director-General, 副所長 (50012779)
NEJIME Tetsuya Serotec Research Institute Deputy Director, 所長代理
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2002: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2001: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥5,700,000 (Direct Cost: ¥5,700,000)
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| Keywords | Viral encephalitis / Tick-borne encephalitis / Differential diagnosis / Vaccine / ダニ媒体脳炎 / 診断 / 診断法 |
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| Research Abstract |
We conducted epidemiological study to specify the endemic area of tick-borne encephalitis (TBE), evaluated the pathogenicity of TBE virus Hokkaido strain and tested the efficacy of European TBE vaccine to Hokkaido TBE virus strain. We also performed phylogenetic study of TBE virus Hokkaido strainsto estimate the origin.
The results showed that TBE virus distribute in southern part of Hokkaido from the positive antibody results in dog and horse sera. Reservoir animals of TBE virus in Hokkaido were found to be Clethrionomys rufocanus and Apodemus speciosus from virus isolation results. TBE virus Hokkaido strains possessed common pathogenicity shared among TBE virus strains. TBE virus Hokkaido strain diverged from ancestor virus in Far East several hundred years ago. Another subtype of TBE virus, Siberian subtype was found to distribute in Siberian area of Russia. European type TBE virus vaccine was found to be efficacious to TBE virus Hokkaido, Far Eastern and Siberian strains. Monochlonal antibodies against TBE virus Hokkaido strain were produced and found to be useful for diagnosis.
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