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Targeting Hyperthermia by RF Inductive Heating for Selective Heating of Cancer

Research Project

Project/Area Number 12558106
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Biomedical engineering/Biological material science
Research InstitutionTHE UNIVERSITY OF TOKYO (2001-2002)
Nagoya University (2000)

Principal Investigator

SHINKAI Masashige  School of Eng., Dept. of Chem. & Biotech., Lecturer, 大学院・工学系研究科, 講師 (70262889)

Co-Investigator(Kenkyū-buntansha) KAWAI Noriyasu  Nagoya City Univ., School of Med., Lecturer, 医学部, 講師 (20254279)
YAMAMOTO Itsuo  Yamamoto Vinyter, Institute Head, 高周波研究所, 所長(研究職)
KOBAYASHI Takeshi  Nagoya Univ. Grad. School of Eng., Professor, 大学院・工学研究科, 教授 (10043324)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2002: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2001: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2000: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsHyperthermia / Cancer therapy / Magnetic Particles / RF Capacitive Heating / RF Inductive Heating / prostate canser / Melanoma / Heat Immunotherapy / RF誘電加温法 / 誘電加温 / 誘導加温 / ドラッグデリバリー / ターゲティング / RF波 / 加温材料
Research Abstract

1. Improvement of RF specific heating device
Characteristics of particulate heating mediators in radiofrequency (RF) capacitive hyperthermia were investigated. Four ferromagnetic ferrite particles (Cu(II)Fe(III)2O3, Mg(II)Fe(III)2O3, Mn(II)Fe(III)2O3, and Ni(II)Fe(III)2O3) in addition to magnetite particles and other non-ferromagnetic metal oxide particles (a-Fe2O3, a-Alumina, Ag(II)O, and ZnO) were tested using 8 MHz RF heating device. As a result, ferromagnetic particles could generate heat specifically in RF capacitive, but non-ferromagnetic particles could not. In addition, dispersiblity of particles was an important parameter for heat generation.
2. Preparation of biocompatible heating mediator
Magnetite needle, in which magnetite particles are molded into needle-shape, was developed and we applied it as a heating mediator for intracellular hyperthermia. We investigated the hyperthermic effect on solid subcutaneous gliomas in the femoral region of female F344 rats. The tumor tissue completely disappeared in many rats exposed to a magnetic field, and the needles were simply administered through a syringe. The magnetite needle will be a novel and potentially effective mediator of hyperthermia that can be used to treat other malignant solid tumors without severe side effects.
3. Specific heating and effect of magnetic particles in RF heating
Magnetite cationic liposomes (MCLs) were injected in a rat tumor on femur and an 8 MHz-RF capacitive heating was applied to the rat under the conditions of 'mild heating'. The MCLs-injected tumor was heated over 43℃ whereas it was only heated until 41℃ in the case of the rats injected no MCLs. The necrotic area of tumor was observed in the heated rat.
4. Safety of heating mediator
No toxico effect of heating mediator was observed in all invetigations.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] B.Le, M.Shinkai, T.Kitade, H.Honda, J.Yoshida, T.Wakabayashi, T.Kobayashi: "Preparation of tumor-specific magnetoliposomes and their application for hyperthermia"Journal of Chemical Engineering Japan. 34. 66-72 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Shinkai, B.Le, H.Honda, K.Yoshikawa, K.Shimizu, S.Saga, T.Wakabayashi, J.Yoshida, T.Kobayashi: "Targeting hyperthremia for renal cell carcinoma using human MN antigen-specific magnetoliposomes"Japanese Journal of Cancer Research. 92. 1138-1145 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Shinkai, K.Ueda, S.Ohtsu, H.Honda, K.Kohri, T.Kobayashi: "Effect of functional magnetic particles on radiofrequency capacitive heating : An in vivo study"Japanese Journal of Cancer Research. 93. 103-108 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Shinkai, K.Ueda, S.Ohtsu, H.Honda, K.Kohri, J.Inoue, T.Kobayashi: "Characteristics of particulate heating mediator in RF capacitive heating"Japanese Journal of Hyperthermia Oncology. 18. 33-41 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Shinkai, K.Ueno, H.Honda, T.Kobayashi: "Magnetite needle as heating mediator for intracellular hyperthermia of tumor"Japanese Journal of Hyperthermia Oncology. 18. 191-198 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A.Ito, K.Tanaka, K.Kondo, M.Shinkai, H.Honda, K.Matsumoto, T.Saida, T.Kobayashi: "Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma"Cancer Science. 94. 308-313 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] B. Le, M. Shinkai, T. Kitade, H.I Honda, J. Yoshida, T .Wakabayashi, T. Kobayashi: "Preparation of tumor-specific magnetoliposomes and their application for hyperthermia"Journal of Chemical Engineering Japan. 34. 66-72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Shinkai, B. Le, H. Honda, K. Yoshikawa, K. Shimizu, S.Saga, T. Wakabayashi, J. Yoshida, T. Kobayashi: "Targeting hyperthermia for renal cell carcinoma using human MN antigen-specific magnetoliposomes"Japanese Journal of Cancer Research. 92. 1138-1145 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Shinkai, K. Ueda, S. Ohtsu, H. Honda, K. Kohri, T. Kobayashi: "Effect of functional magnetic particles on radiofrequency capasitive heating : An in vivo study"Japanese Journal of Cancer Research. 93. 103-108 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Shinkai, K. Ueda, S. Ohtsu, H. Honda, K. Kohri, J. Inoue, T. Kobayashi: "Characteristics of particulate heating mediator in RF capacitive heating"Japanese Journal of Hyperthermia Oncology. 18. 33-41 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Shinkai, K. Ueno, H. Honda, T. Kobayashi: "Magnetite needle as heating mediator for intracellular hyperthermia of tumor"Japanese Journal of Hyperthermia Oncology. 191-198 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A. Ito, K. Tanaka, K. Kondo, M. Shinkai, H. Honda, K. Matsumoto, T. Saida, T. Kobayashi: "Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma"Cancer Science. 308-313 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Shinkai, K.Ueda, S.Ohtsu, H.Honda, K.Kohri, J.Inoue, T.Kobayashi: "Characleristics of particulate heating mediator in RF capacitive heating"Japanese Journal of Hyperthermia Oncology. 18. 33-41 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Shinkai, K.Ueno, H.Honda, T.Kobayashi: "Magnetite needle as heating mediator for intracellular hyperthermia of tumor"Japanese Journal of Hyperthermia Oncology. 18. 191-198 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] M.Shinkai, B.Le, H.Honda, K.Yoshikawa, K.Shimizu, S.Saga, T.Wakabayashi, J.Yoshida, T.Kobayashi: "Targeting hyperthremia for renal cell carcinoma using human MN antigen-specific magnetoliposomes"Japanese Journal of Cancer Research. 92. 1138-1145 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Shinkai, K.Ueda, S.Ohtsu, H.Honda, K.Kohri, T.Kobayashi: "Effect of functional magnetic particles on radiofrequency capasitive heating: An in vivo study"Japanese Journal of Cancer Research. 93. 103-108 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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