| Project/Area Number |
12670004
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
MURAKAMI Tohru (2001) Gunma University School of Medicine, Department of Anatomy, Associate Professor, 医学部, 講師 (10239494)
石川 春律 (2000) 群馬大学, 医学部, 教授 (90010058)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIJIKATA Takao Gunma University School of Medicine, Department of Anatomy, Assistant Professor, 医学部, 助手 (70189786)
村上 徹 群馬大学, 医学部, 講師 (10239494)
藤巻 昇 群馬大学, 医学部, 講師 (10008261)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
|---|
| Keywords | plasmalemmal undercoats / cytoskeletons / cell adhesion / development / molecular architectures / corrated microscopy / confocal microscopy / electron microscopy / 形質膜 / 共焦点レーザー顕微鏡 / 電子顕微鏡 / 平滑筋細胞 / プレクチン / 神経周膜 |
|---|
| Research Abstract |
Cytoskeletons are among the key components of prokaryotic cells playing such rolls as a cellular mechanical support as well as cytokinesis, cell adhesion, signal transmission, cell differentiation and development. Many of their functions are based on the mechanical and structural associations with cell adhesion structures and plasmalemmal undercoat. We studied such associations in muscle cells and perineurial cells by electron microscopy correlated with confocal microscopy and biochemical techniques. Additionally we investigated the induction of cell adhesion by rostral determinant gene Otx in developing vertebrate embryos by correlated molecular biology and microscopy. We also identified a protocadherin as a morphoregulator of somitogenesis.
|
